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Biomedical subjects

S Thurber

Publications and source records attributed to S Thurber.

28 records · Page 2Linked to original sources
PubMed1976

Internal-external control, interpersonal trust, and the motive to avoid success in college women.

The Internal-External Control scale, Interpersonal Trust scale, and an assessment of the Motive To Avoid Success were administered to 86 undergraduate women. As expected, external and low trust scores covaried with comparatively high levels of achievement-related anxiety. The results were interpreted in terms of possible repression tendencies of internal subjects and the defensive properties inherent in the external and low trust belief systems.

Achievement↗
PubMedDate not supplied

Neuroprotective effect of felbamate after kainic acid-induced status epilepticus.

Felbamate (FBM), a newly developed antiepileptic drug (AED), was previously shown to offer some neuroprotective effects against hypoxic injury in both in vivo and in vitro studies. We administered FBM (100 or 300 mg/kg) to 30-day-old rats 1 h after they received a convulsant dosage of kainic acid (KA). Animals were then tested at age 80 days in the water maze, open field, and handling tests. Seizure latency was then tested by flurothyl inhalation. Animals that received 300 mg/kg FBM performed better in all three tests and had longer latencies to flurothyl-induced seizures than did animals that received vehicle. This study suggests that FBM may have some neuroprotective effects after KA-induced status epilepticus (SE).

Animals↗
PubMedDate not supplied

Age-dependent cognitive and behavioral deficits after kainic acid seizures.

The long-term behavioral and cognitive effects of seizures at different ages were studied using the kainic acid (KA) seizure model. Rats of postnatal (P) ages (in days) 5, 10, 20, 30, and 60 were administered KA intraperitoneally (i.p.), which induced status epilepticus for several hours, or an equivalent volume of saline. Occurrence of spontaneous recurrent seizures (SRS) was then monitored for 3 months by a closed-circuit videotaping system. Rats began behavioral testing on P80; a separate group of rats that received KA on P60 began testing on P120. Behavioral tests included the Morris water maze (visuospatial learning and memory), the open field test (response to a novel environment), and the handling test (emotionality). When tested on P80, KA-treated P5 and P10 rats had no demonstrable deficits on any test as compared with controls. KA-Treated P20 rats differed from controls only on the water maze spatial bias test. KA-Treated P30 rats had deficits in spatial bias, were more active in the open field, and were more aggressive when handled. KA-Treated P60 rats, whether tested on P80 or P120, had deficits in learning platform position and spatial bias in the water maze, were more active in the open field, and were more aggressive when handled. P60 rats with SRS performed poorer in water maze place learning and spatial bias testing, although the number of SRS did not correlate with overall task acquisition. Our findings suggest age-related behavioral and cognitive deficits after KA-induced seizures. Pubescents and adults had alterations in learning, memory, exploratory behavior, and response to handling, whereas younger animals had no obvious behavioral or cognitive deficits.

Age Factors↗