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S Thunold

Publications and source records attributed to S Thunold.

At least 19 recordsLinked to original sources
PubMed1995

The pattern of malignant lymphoma in Oman.

The pattern of malignant lymphoma (ML) in the Middle East has not been well documented and constitutes a lacuna in the epidemiology of this disease. This preliminary report describes a retrospective study of 46 native Omanis who, at the Sultan Qaboos University Hospital and the Royal Hospital, Sultanate of Oman, were diagnosed in 1990 as having ML. Of the 46 patients with ML, 16 (35%) were found to have Hodgkin's disease (HD) and 30 (65%) had non-Hodgkin's lymphomas (NHL). Among the HD, mixed cellularity (MC) appeared in 9 cases (56%). Among the NHL, 25 (83%) showed a diffuse pattern and 5 (17%) were follicular. Twenty-one (70%) of the NHL were of high-grade type, of which 5 (17%) were Burkitt-like lymphomas. Immunological study of the NHL biopsies revealed 24 (80%) of the B cell type, 2 (7%) of the T-cell type, 1 (3%) of the null cell type and 3 (10%) could not be classified because of scanty material or unsatisfactory fixation. We present in this study the pattern of ML in Oman, which was found to be different from those reported from the West, Far East and Saudi Arabia, with some resemblance to the pattern from tropical Africa.

Adolescent↗
PubMed1992

Koilocytosis in neoplasia of the urinary bladder.

Koilocytosis is commonly regarded as indicative of human papilloma virus infection in the uterine cervix. In 1987 morphologically similar changes were reported in bladder tumours. This is confirmed in the present study, the incidence here being 65%. In addition the incidence of koilocytic change was shown here to increase from non-infiltrative WHO grade I to infiltrative WHO II lesions, and to be more common in bladder lesions in women with cervical koilocytosis. The latter is in keeping with our previous report that the incidence of koilocytosis in the cervix of patients with bladder neoplasia is higher than expected in the general population, adding support to the hypothesis that both lesions may be virus-related.

Adult↗
PubMed1991

Risk of cervical intraepithelial neoplasia in women with glomerulonephritis.

OBJECTIVE: To investigate the occurrence of cervical intraepithelial neoplasia in women with glomerulonephritis and its possible association with immunosuppressive treatment. DESIGN: Retrospective study of cytological or histological specimens from women presenting with glomerulonephritis and a group of case and age matched controls. SETTING: University department of pathology, Norway. PATIENTS: 81 women presenting with glomerulonephritis from 1981 to 1988, from whom gynaecological cytological or histological specimens were available. A group of 162 case and age matched controls. MAIN OUTCOME MEASURES: Age when glomerulonephritis of cervical intraepithelial neoplasia was diagnosed, type and characteristics of kidney lesion, stage of cervical intraepithelial neoplasia and presence of human papillomavirus, use of immunosuppressive treatment. RESULTS: Cervical intraepithelial neoplasia was more common in women with glomerulonephritis than in their controls (16/81 (20%) v 7/162 (4%), p less than 0.001) and was more advanced in those with glomerulonephritis than in the controls (9/81 (11%) of the study group had grade III cervical intraepithelial neoplasia compared with 1/162 (1%) of the controls). The increased occurrence of cervical lesions was independent of the use of immunosuppressive treatment, but the individual lesions tended to be more advanced when it was used (four of the seven cervical lesions in women with glomerulonephritis who had received immunosuppressive treatment were carcinoma in situ). Of the nine cervical lesions tested, seven were virus associated. CONCLUSION: Women with glomerulonephritis should have regular cervical smears, irrespective of their use of immunosuppressive treatment.

Adult↗
PubMed1991

IgG Fc receptors on epithelial cells of distal tubuli and on endothelial cells in human kidney.

IgG Fc receptors (FcR) in cryostat sections of human kidney were studied using functional assays and monoclonal antibodies (MoAbs). Using functional assays, FcR were detected on cells in glomeruli and distal convoluted tubuli, on endothelial cells and on interstitial cells. These cells were also stained with B1D6, a MoAb reactive with a 40-kD molecule with low affinity FcR activity. Using MoAbs against leukocyte FcR, a different pattern of reactivity was obtained. MoAbs against FcR I (32.2), FcR II (IV.3 and C1KM5) and FcR III (3G8 and Leu11b) stained interstitial macrophages only. The data confirm the presence of FcR on renal glomeruli and interstitial cells and also indicate that epithelial cells of distal tubuli and endothelial cells express FcR. Furthermore, renal FcR appear to be structurally different from the FcR I, II and III defined on leukocytes.

Antibodies, Monoclonal↗
PubMed1990

[Heart disease in myasthenia gravis].

The symptoms in myasthenia gravis are mainly due to reduced function of skeletal muscle. But some patients, especially those with a thymoma, have symptoms or signs of myasthenia-related heart disease. Some of our patients with histological myocarditis have died suddenly and unexpectedly. The frequency of electrocardiographic abnormalities among myasthenic patients has increased. Patients with myasthenia gravis should be subjected to cardiac monitoring after thymic surgery and during myasthenic crisis and other severe illnesses. If clinical examination leads to suspicion of myocarditis, the patient should receive immunosuppressive therapy.

Adult↗
PubMed1990

Successful pregnancy following treatment of primary malignant lymphoma of the uterine cervix.

A case of primary histiocytic lymphoma in the uterine cervix of a 22-year-old nulligravid woman is reported. To avoid surgical or radiological castration she received six courses of combination chemotherapy (cyclophosphamide 750 mg/m2, doxorubicin 50 mg/m2, vincristine 2 mg all iv on Day 1 and then together with oral prednisone 50 mg twice daily on Days 1-5). Approximately 20 months after therapy she delivered a healthy child. Six years have passed since primary treatment was initiated. No evidence of recurrent lymphoma has been observed.

Adult↗
PubMed1989

Endodermal sinus tumor treated with high dose cisplatin.

A woman with an endodermal sinus tumor of the ovary stage IV obtained a short but complete remission after treatment with vinblastine, bleomycin and standard dose cisplatin. A second complete remission for 42+ months was obtained with a regimen of vinblastine, bleomycin, etoposide, and high dose cisplatin. This result suggests a dose-response relationship for cisplatin in ovarian germ cell tumors.

Adult↗
PubMed1986

Thymic lymphoepitheliomas and skeletal muscle expressing common antigen(s).

Rabbit antiserum to a citric acid extract of human skeletal muscle (CA) stained epithelial thymoma cells as well as skeletal muscle. Thymomas from two myasthenia gravis (MG) patients showing no circulating anti-CA antibodies prior to thymectomy were also stained by the antiserum. Thus, in these patients as well, the thymoma and skeletal muscle possess common antigens. The rabbit and the human antibodies most probably reacted with different antigens, apparently located close to each other in the cell membrane. The reason why anti-CA antibodies cannot be detected in serum from a few MG patients with a thymoma may be that the thymoma-associated antigen is not present in vivo in these cases, or that an inhibiting factor blocks the antibody synthesis. Both patients developed anti-CA antibodies post-operatively, which favours the latter explanation.

Absorption↗
PubMed1982

IgG-Fc and C3 receptors in the chicken: distribution, tissue localization and functional significance.

This paper summarizes data obtained in our laboratory on the demonstration of receptors for IgG-Fc (FcR) and complement (CR) on mononuclear cells of the fowl. A clearcut distinction of these two structures on spleen cells was achieved in rosette assays using SRBC coated with rabbit IgG as indicator cells which bind avian complement, but are not bound by the FcR. The tissue distribution and localization of FcR and CR positive cells was studied in mixed hemadsorption assays on sections of both central (bursa, thymus) and peripheral (spleen) lymphoid organs from normal chickens, as well as lymphocytic infiltrated thyroid glands from animals of the Obese strain (OS) afflicted with spontaneous autoimmune thyroiditis. The possible significance of both receptors in the pathogenesis of this autoimmune process is discussed.

Animals↗
PubMed1982

The localization of glomerular C3b receptor by immunoelectron microscopy.

By an indirect immunoperoxidase technique, rabbit antiserum to solubilized C3b receptor stained the glomeruli in cryostat sections of human kidney. The staining was localized to the glomerular basement membrane zone. Glomeruli in sections of aldehyde-fixed paraffin-embedded tissue did not stain. However, if the sections were pretreated with proteolytic enzymes, the glomeruli were stained by the antiserum as in the cryostat sections. Electron microscopy revealed that the reaction product was located in the cell membrane of the epithelial cells. In some cells the reaction product was also found in vacuoles in the cytoplasm. The basement membrane and endothelial and mesangial cells did not stain.

Basement Membrane↗
PubMed1982

Tissue localization of lymphocyte surface antigens and receptors for immunoglobulin G Fc and complement in the chicken.

Frozen sections of chicken lymphoid organs were examined for lymphocyte surface antigens by antisera to T and B lymphocytes (ATS;ABS), and for the presence of immunoglobulin (Ig) G Fc and complement receptors (FcR;CR) by hemadsorption with sheep erythrocytes (E) coated with chicken IgG(EA), and E coated with rabbit IgG and chicken complement (EAC). In the spleen FcR positive cells were confined to the periellipsoidal sheaths and the germinal centers. CR positive cells were found in the same spleen areas, as well as in the medulla of bursal follicles. These lymphoid areas reacted strongly with ABS, but they also stained with neutral alpha-naphthyl butyrate esterase, and phagocytosed carbon particles were found in the periellipsoidal sheaths. Furthermore, in vivo treatment with cyclophosphamide, which resulted in pronounced B-lymphocyte depletion, did not affect FcR activity, but reduced CR activity significantly. These data indicate that the FcR activity demonstrated in tissue sections is mainly confined to mononuclear phagocytes, while the CR positive cells are mainly B lymphocytes.

Animals↗
PubMed1981

Localization of IgGFc and complement receptors in chicken lymphoid tissue.

Chicken lymphoid organs were examined for IgGFc and complement receptors (FcR/CR) by immune adherence on frozen tissue sections. Indicator systems were sheep erythrocytes (E) coated with chicken anti-E IgG (EAch), E coated with rabbit anti-E IgG (EArab) and normal chicken serum (EAC), and FITC-labelled zymosan particles coated with chicken serum (ZyC). In the spleen, FcR and CR activity was confined to B-dependent areas, i.e. the periellipsoidal sheaths and germinal centres and the red pulp. No FcR were found in the thymic or bursal lymphoid tissue, but CR activity was observed in the medulla of bursal follicles. Chicken and turkey IgG, chicken IgGFc, and bovine serum albumin (BSA)--chicken anti-BSA complexes inhibited binding of Each. No inhibition was obtained with chicken IgGF(ab')2, IgM or albumin, or with BSA--rabbit anti-BSA complexes and human or rabbit IgG. E did not adhere to the sections, nor did EArab, EArab incubated with heat-inactivated chicken serum, or EAC complexes prepared with EArab and guinea-pig complement. The data suggest that chicken B lymphocytes and macrophages have receptors for avian IgGFc and C which can be demonstrated in tissue sections.

Animals↗
PubMed1981

Serological detection of thymoma in myasthenia gravis.

A purified citric acid extract (CAE) was prepared from skeletal muscle and coated onto sheep red cells for use in an indirect hemagglutination test. Out of 64 MG sera examined, only 5 contained antibodies to the CAE. Radiological evidence of a thymoma was found in 1, but thymectomy revealed a lymphoepithelioma in all 5 patients. In 4 of the patients, the tumor was very small or medium-sized. None of the CAE-negative patients had clinical, radiological or other evidence of a thymoma. The test in therefore a supplementary diagnostic method for the detection of a thymoma at an early stage.

Aged↗