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Biomedical subjects

S Thornton

Publications and source records attributed to S Thornton.

At least 73 records · Page 4Linked to original sources
PubMed1995

Computer image sperm selection as a novel approach to subzonal insemination in the human.

Utilizing real-time computer image analysis, individual spermatozoa were selected using microaspiration. Selection criteria were based on potential hyperactivation motility characteristics; the amplitude of lateral head displacement > 7.5 microns, curvilinear velocity > 70 microns/s and linearity of < 30%. For this pilot study, 16 patients (eight in each group) were recruited. Using subzonal insemination (SUZI), up to five (mean = 4.4 +/- 0.3) spermatozoa selected using computer-image sperm selection (CISS) were micro-injected, or up to 15 (mean = 12.8 +/- 1.3 SD) unselected spermatozoa. In the group which utilized CISS, 28 out of 49 (57%) oocytes were fertilized compared with 13 out of 52 (25%) utilizing conventional SUZI (P < 0.04); polyspermy was 20% (n = 10) and 2% (n = 1) respectively. CISS with SUZI showed increased efficiency in achieving fertilization and is a novel approach to studying individual sperm function in a sperm egg bioassay where gamete ratios are close to unity.

Adult↗
PubMed1994

Simple method for polyp retrieval during colonoscopy.

Retrieval of small polyps can often be frustrating for the skilled endoscopist. We introduce a technique of polyp retrieval that is simple and effective in yielding intact specimens for accurate pathologic examination.

Biopsy↗
PubMed1994

Threat of hepatitis E virus infection in Somalia during Operation Restore Hope.

In support of Operation Restore Hope, the United States military established a diagnostic laboratory for infectious diseases, the Joint Forward Laboratory, in Mogadishu, Somalia. Because sporadic hepatitis due to unknown causes was a frequent problem, staff members of the Joint Forward Laboratory evaluated 31 Somalis, five displaced Ethiopians, and three Western relief workers who had acute clinical hepatitis. Patients lived in multiple locations in Somalia--Mogadishu, Baidoa, and Merca--and became ill between December 1992 and February 1993. IgM antibody to hepatitis A virus was found in one English relief worker, and IgM antibody to hepatitis E virus was found in 20 (65%) of 31 Somalis, two (40%) of five Ethiopians, and two (67%) of three Western relief workers. No patient had evidence of acute hepatitis B, malaria, yellow fever, or other arbovirus infections. These data indicate that hepatitis E virus--the major cause of enterically transmitted non-A, non-B hepatitis--was a common cause of acute sporadic hepatitis in Somalia during the initial stages of Operation Restore Hope.

Disease Outbreaks↗
PubMed1994

Highly resistant bacterial osteomyelitis in Somalia.

Chronic osteomyelitis is a major health problem in the aftermath of the conflict in Somalia. We studied the microbiology of chronic osteomyelitis among 30 patients in a large hospital in Mogadishu. Gram-negative bacteria were isolated from 77% of patients; most of these isolates were highly resistant to standard antibiotic agents but all were sensitive to ciprofloxacin, an oral fluoroquinolone antibiotic. Ciprofloxacin may prove useful in the management of chronic osteomyelitis due to highly resistant gram-negative bacteria.

Chronic Disease↗