Search PubMed⌕ Search

Biomedical subjects

S Thanikachalam

Publications and source records attributed to S Thanikachalam.

At least 19 recordsLinked to original sources
PubMed2006

Quantitative evaluation of left ventricle performance from two dimensional echo images.

OBJECTIVES: We sought to quantify the left ventricle systolic dysfunction by a geometric index from two-dimensional (2D) echocardiography by implementing an automated fuzzy logic edge detection algorithm for the segmentation. BACKGROUND: The coronary injuries have repercussions on the left ventricle producing changes on wall contractility, the shape of the cavity, and as a whole changes on the ventricular function. METHODS: 2D echocardiogram and M-mode recordings were performed over the control group and those with the dysfunctions. From 2D recordings, individual frames were extracted for at least five cardiac cycles and then segmentation of left ventricle was done by automated fuzzy systems. In each frame, the volumes are measured and a geometric index, eccentricity ratio (ER), was derived. The endocardial fractional shortening (FS), midwall fractional shortening (mFS), and the relative wall thickness (RWT) were also measured in each case. RESULTS: Depressed value of endocardial FS (20.39 +/- 5.43 vs 34.28 +/- 9.36, P = 0.0046), mFS (33 +/- 8.3 vs 52.5 +/- 11.7, P = 0.0047), and the RWT (0.337 +/- 0.096 vs 0.525 +/- 0.119, P = 0.0002) was observed with dysfunction. ER measured at end-diastole (2.86 +/- 0.703 vs 4.14 +/- 0.38) and end-systole (3.14 +/- 0.79 vs 5.48 +/- 0.74) was found to be decreased in the dysfunction group and more significant at the end-systole (P = 0.00017 vs 6.6E-06). CONCLUSION: This work concludes that the regional and global left ventricle systolic dysfunction can be assessed by the ER measured at end-diastole and end-systole from 2D echocardiogram and may contribute to the high rate of cardiovascular disorders.

Adult↗
PubMed2005

Detection of left ventricle systolic dysfunction from shape deformity.

Coronary artery disease producing ischemic cardiomyopathy is the most frequent cause of left ventricular systolic dysfunction. Non-ischemic cardiomyopathies can also produce systolic dysfunction; they may be inherited as genetic disorders or occur sporadically. These coronary injuries have repercussions on the left ventricle producing changes on wall contractility, the shape of the cavity and also changes on ventricular function. This study is focused on the 2D echocardiograms of the left ventricle. Apical two chamber and four chamber view recordings were performed on normal and systolic dysfunction subjects. Individual frames were extracted for at least five cardiac cycles. After pre-processing these images, segmentation of the left ventricle was performed by Fuzzy systems. Then the volumes were measured by single and biplane methods along with the perimeter, short axis length and long axis length in each frame, from which the two indices Sphericity Index (SI) and Normalized Eccentricity Index (NEI) was determined. It was found that the diastolic phase is short in the case of systolic dysfunction, and its volume variation is not uniform as in the normal case. Also, in the case of systolic dysfunction, the span of either the long or short axis length variation is less than 0.5 cm. This depicts that akinesis is in the corresponding direction; the value of SI is less than 2 for systolic dysfunction. A sharp peak is seen at each systole point in the NEI plot and also its variation is smooth in subjects having LVEF > 45%, which is not the case for dysfunction.

Algorithms↗
PubMed2003

Catheter intervention in valvular obstruction and long-term results.

Percutaneous balloon mitral valvuloplasty has been established as an effective alternative to surgery for the treatment of mitral stenosis. The authors describe their experience in percutaneous mitral commissurotomy with a detailed discussion of the procedures and a brief review of literature.

Adolescent↗
PubMed2000

Dermatofibroma of the eyelid: a case report.

A 5-year-old girl presented with a large swelling measuring 50 x 35 mm in the left upper lid. The mass was firm to hard in consistency. Fine-needle aspiration showed a few spindle-shaped cells arranged in clusters. The mass was excised in toto and the histopathological examination revealed dermatofibroma, which is an extremely rare condition affecting the eyelid.

Journal Article↗
PubMed1999

Retrobulbar optic nerve cysticercosis with surgical removal: a case report.

A 15-year-old boy presented with diminution of vision which rapidly progressed to no perception of light. In the ocular fundus, a neuroretinitis-like picture was seen. On CT-scan & ultrasonography, an optic nerve swelling was detected with a shadow of scolex. Medical therapy in the form of steroids along with albendazole was ineffective. Surgical removal by lateral orbitotomy was done and a complete cyst with scolex was removed, which was confirmed histopathologically as a case of retrobulbar optic nerve cysticercosis.

Journal Article↗
PubMedDate not supplied

Comparison of target concentration intervention strategy with conventional dosing of digoxin.

Digoxin is a widely used drug in patients with congestive heart failure. The present study compared the quality of life of congestive heart failure patients on one year follow-up period with two different dosing of digoxin (5/7 therapy and 7/7 therapy in whom the target serum digoxin concentration is maintained). Quality of life significantly improved in intervention group thus emphasizing the need for continuous dosing of digoxin based on target concentration.

Cardiotonic Agents↗