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Biomedical subjects

S Terui

Publications and source records attributed to S Terui.

45 records · Page 3Linked to original sources

[Gamma dose estimation to the gastric wall after administration of a capsule containing a large dose of 131I (author's transl)].

Gamma dose to the gastric wall from a capsule containing 1.85 GBq (50 mCi) of 131I was estimated in 6 patients who had received total thyroidectomy for thyroid carcinoma some years before. The tests were done with a 37 MBq (1 mCi) capsule each in 5 patiens and with a 185 MBq (5 mCi) capsule in one patient. All the patients were requested to fast in the morning. The capsule was given with a glass of water (200 ml). Then, the patient kept supine position under the scintillation camera for a period of one hour except one patient on whom the test was suspended at 30 minutes because of early clearance of the radioactivity from the stomach. In one of 5 patients who were tested for a period of one hour, serial scinticamera images showed almost no movement and minimum dissolution of the capsule. The remaining 4 patients showed slight to moderate movements of the capsules with a variety of dissolution speeds. Data processings were done by Scintipac-1200. The estimated doses at the distance of 0.5 cm from the source were 3.820, 2.074, 1.445, 1.154 and 1.462 grays (382.0, 207.4, 144.5, 115.4 and 146.2 rads) per initial one hour and 375 mGy (37.5 rad) per initial 30 minutes, respectively. From these data, it is thought to be wise to advise the patient to rotate or shake the body on bed occasionally after swallowing the capsules containing a large dose of 131I for the treatment of thyroid cancer. It is also desirable to recommend the patient to walk around even though the controlled patient's room is small. Additional water may be also meaningful to avoid unnecessary irradiation to the gastric wall.

Adult↗

Subtraction scintigraphy with 67Ga-citrate and 99mTc-colloid in the diagnosis of intrahepatic masses.

Subtraction scintigraphy of the liver with 67Ga-citrate and 99mTc-colloid (99mTc-phytate) was performed by subtracting the image of the latter from the image of the former in 34 patients who were suspected of having intrahepatic masses, especially hepatoma. The computer used was Scintipac 1200 (32 KW memories and 2.4MBX2 disk memories). Both images were taken in a digital form (128 X 128 elements). After normalizing both images, 4 different factors (0.6, 0.8, 1.0, and 1.2) were applied to the 99mTc image before the subtraction from the 67Ga image. We found that this technique was very useful for the detection of abnormal 67Ga accumulation in the liver.

Adult↗

Clinical, hematological and pathological responses in severely heat-stressed steers with special reference to the threshold value for survival.

To find out a critical point of physiological responses of steers which would finally lead to death due to heat stress, four Holstein steers weighing about 300 kg were housed in an artificial climatic room and exposed to each of the following room temperature and relative humidity: 35 degrees C and 70 per cent, 36 degrees C and 80 per cent, 38 degrees C and 70 per cent, and 42 degrees C and 60 per cent. Sequential clinical and hematological examinations were carried out during thermal loads on the steers, and pathological examinations after their death or slaughter. All the steers manifested panting, rise of rectal temperature, reduction or disappearance of peristalsis, hypersalivation, dysfunction of the skin reflex, and remarkable decrease in white blood cell count and pressure of CO2 (Pco2) value of jugular blood. At the end of heat stress, an animal would be survived if it meet the following conditions: (1) rectal temperature was below 42.7 degrees C, (2) the respiration rate did not decrease to one half (about 100/minute) of the maximum rate during the exposure period, (3) peristalsis and skin reflex disappeared almost completely, (4) the white blood cell count did not decrease to less than 50 per cent of the normal level, and (5) the Pco2 value of venous blood was maintained at a level of more than 15 mmHg. Cloudy discoloration with a boiled-meat appearance was noticed in the skeletal muscle of the hind part of the body in two dead cases. No significant changes were detected in any other steer slaughtered several days after release from the thermal stress.

Animals↗

Pathological and microbiological studies on calf pneumonia occurring in mass rearing facilities.

Pathological and microbiological studies were conducted on lesions in the lungs of 194 calves from mass rearing facilities. Macroscopically, the lesions were classified into six forms: nonlesion, atelectasis, mild pneumonia, moderate pneumonia, advanced pneumonia, and advanced pneumonia accompanied with abscess. Histopathological examination revealed bronchopneumonia in most of the calves. Lesions more advanced than moderate pneumonia were complicated with desquamation, severe exudation, and necrosis. Bacteriologically, Pasteurella sp. was isolated often in combination with Staphylococcus sp. from about a half of the atelectatic cases. With the development of pneumonic lesions, Pasteurella sp. was isolated at a high frequency in combination with Haemophilus sp., Streptococcus sp., and Corynebacterium sp. Prominent necrosis was more often seen in cases with Pasteurella haemolytica isolated than in cases with only Pasteurella multocida isolated. Mycoplasma sp. and Ureaplasma sp. were isolated from distinctly pneumonic lesions. Advanced pneumonic lesions were observed in many calves over 30 days of age. The importance of environmental and managerial improvement was also emphasized, since calf pneumonia tended to break out in facilities under unsatisfactory conditions in the present work.

Animals↗

Whole body bone scintigram and stage classification of the patients with adenocarcinoma of lung.

One hundred and six patients having adenocarcinoma of the lung were studied by whole body bone scanning with 99mTc-phosphates in connection with their clinical stages. Abnormal accumulation was found in 64 patients (60%). There were 64 patients who received surgical treatment. Among these 64 patients, 38 underwent bone scanning within 3 months after the establishment of their clinical stages. Twenty-two of them were classified as Stage I clinically. Pathological stage classification after the surgery revealed these 22 to be classified into 3 groups; 6 for Pathological Stage I, 4 for Pathological Stage II and 12 for Pathological Stage III. None of these 6 in Stage I showed abnormal accumulations. However, 1 of 4 in Stage II and 6 of 12 in Stage III were found to have abnormal accumulations. Therefore, if bone scintigrams had been taken into consideration for clinical stage classification, 7 patients would have never been placed into Clinical Stage I and could be expected more precise treatment. The authors recommend application of the results of whole body bone scanning to stage classification of adenocarcinoma of the lung. Needle biopsy is also recommended to confirm the metastasis at the site of radioisotope accumulation in the rib.

Adenocarcinoma↗