For the last 20 years, vasodilator drugs have been used for the therapy of congestive heart failure. During this period, there has been increasing interest in the treatment of congestive heart failure. Vasodilators are divided into one which reduces preload, another which reduces after-load and the last which has both effects. Changes in cardiac output causes changes in distribution of cardiac output to each organ. Therefore, after vasodilators injection, changes in systemic distribution of blood flow should not be equal in each organ. In this report, changes in systemic distribution of cardiac output after vasodilator injection are discussed. Systemic distribution of blood flow in normal circulation differs from that in abnormal circulation. In this report, effects of vasodilators on systemic distribution of cardiac output in the state of experimentally created heart failure are discussed.

Animals↗

PubMed1984

The evaluation of asymptomatic arterial occlusive disease of the legs using an exercise test.

The Doppler-derived ankle pressure index (API) is a useful indicator of the necessity for peripheral vascular reconstruction of the lower extremities. But the API at rest dose not reflect the functional capacity of leg circulation, especially in the early stage of disease. Therefore, an asymptomatic but hemodynamically significant lesion in one leg is sometimes missed by pressure measurement at rest when there is a severe lesion with symptoms in the other leg. In this study, the API not only at rest but also after exercise was measured in twenty normal subjects and thirty-two patients with angiographically proven arteriosclerosis obliterans. About 60% of the patients had unilateral symptoms, although they had significant disease bilaterally. The API after exercise proved to be more sensitive than the API at rest and may be useful in assessing asymptomatic legs of such patients and determining their surgical indication.

Aged↗

PubMed1984

[A case of malignant schwannoma of the mesentery in a patient with von Recklinghausen's disease].

A 23-year-old man with Von Recklinghausen's disease was admitted because of abdominal pain. The preoperative diagnosis was malignant mesenteric tumor. Laparotomy was done and the tumor was located in the mesentery of the ileum which showed numerous tortuous cords or bulbous projections from the surface. Partial resection of the involved ileum and the mesentery was performed. Histological examination revealed plexiform neurofibroma and malignant Schwannoma of the mesentery. It is very difficult to preoperatively diagnose early associated lesions of Von Recklinghausen's disease. Therefore, careful examination of the GI tract is important so that earlier therapy can be carried out.

Adult↗

PubMed1984

[Lithium induced sinus node dysfunction].

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Bipolar Disorder↗