Thyroid cancer: surgical management.
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Biomedical subjects
Publications and source records attributed to S Taylor.
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For administrators who joined the service before reorganisation, the temptation to look back affectionately at times when planning followed the local authority model is often too difficult to master. Here, Steve Taylor, research assistant with Clwyd AHA, looks again at the corporate planning mechanisms in local government and argues that they still hold lessons which the NHS may need to re-learn in the future.
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Primary hyperparathyroidism in pregnancy is uncommon and easily overlooked. It is associated with a complication rate of up to 80 per cent--mainly stillbirths, abortions and neonatal tetany. Surgical treatment during pregnancy offers the best chance for fetal and neonatal survival.
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Computed tomography of the spinal cord was a natural development of total body scanning. Much time and effort was spent in order to visualize the spinal cord and the various conditions affecting it. This was achieved by using an EMI CT5005 scanner and a series of step by step modifications and improvements to obtain a very high degree of resolution. The large variety of intraspinal lesions seen at the Montreal Neurological Hospital allowed us, by selecting appropriate cases, to determine the value of CT of the spinal cord.
This patient with histologically proved Riedel's thyroiditis had hypothyroidism of sufficient severity to cause panhypopituitarism, and it was this which first brought him to medical attention. The beneficial effects are described of surgery in relieving severe dysphagia and stridor, and of prednisone in softening and shrinking the hard neck mass. The extent of pituitary failure, and the degree of recovery on treatment with thyroxine are reported, together with details of 4 other cases of Riedel's thyroiditis seen by one of the authors (S.T.).
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It is timely to review the place of surgery in the treatment of thyroid disease when for some years endocrinologists, pharmacologists, and radiotherapists have made most of the running. This account falls naturally into three parts, simple, malignant, and toxic goitre.
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Fifty patients with a chronic form of arthritis were given a standard interview concerned with establishing what knowledge they had of their disease and the drugs they were receiving for its treatment. Eighty-six percent of patients overall knew the name of their disease and 74 percent, the names of the drugs which they were receiving. Seventy-three percent of patients receiving non-steroidal anti-inflammatory drugs were unaware that these drugs were likely to have gastro-intestinal side effects even though about half of these patients were receiving either soluble aspirin or indomethacin. Younger patients were more likely to be aware of potential gastro-intestinal side effects (46 percent) than older patients (19 percent). Thirteen patients with rheumatoid arthritis were receiving myocrisin or penicillamine which are more likely to be associated with severe side effects than non-steroidal anti-inflammatory drugs. Four of five younger patients had some knowledge of the likely side effects of these drugs but none of the eight older patients knew this information. Written instructions should be given to older patients receiving these potentially toxic drugs.
Medullary thyroid carcinoma (M.C.T.) is a tumour of the calcitonin-secreting cells of the thyroid gland; it affects both lobes, has a variable malignant potential, and is often familial. Despite the availability of diagnostic plasma-calcitonin immunoassays, the condition is rarely considered in the initial assessment of a patient with a thyroid mass so that the is often disseminated by the time it is diagnosed, inadequate surgery is performed, and family members are not investigated. We studied 22 members of a family with M.C.T. and gave alcohol to provoke calcitonin secretion. 3 (excluding the index case) had raised basal calcitonin levels and the diagnosis of M.C.T. was confirmed at operation; their calcitonin levels became undetectable after total thyroidectomy. 3 others had detectable levels after alcohol stimulation and are being re-screened at regular intervals.
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The clinical and biochemical features of essential fatty acid deficiency are described in an infant with gastroschisis who required long-term (6 mo) parenteral nutrition. The deficiency responded to therapy with Intralipid, topical sunflower oil, and breast milk. In a prospective study of three infants with gastroschisis, biochemical essential fatty acid deficiency developed in each during the first week of lipid-free parenteral nutrition; clinical signs of the deficiency were absent. The biochemical features were progressive in the one patient followed for 19 days, and were associated with a decrease in weight gain. Both the deficiency and weight gain were corrected by Intralipid. Biochemical essential fatty acid deficiency did not develop in three other gastroschisis infants who were given prophylactic Intralipid (two patients) or topical sunflower oil (one patient). We conclude that all infants on parenteral nutrition should receive a source of linoleic acid to prevent essential fatty acid deficiency.