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Biomedical subjects

S Tarkowski

Publications and source records attributed to S Tarkowski.

At least 19 recordsLinked to original sources

[Assessment of exposure to bioaerosols in workplace ambient air during municipal waste collection and disposal].

The assessment of the exposure to bioaerosols among workers engaged in the collection and disposal of municipal waste is presented. The workers were divided into the following groups, depending on the job performed: waste collectors (loaders, drivers), composting plant workers (heavy equipment operators, waste site workers), sorters (heavy equipment operators, waste sorters) and landfill site workers (heavy equipment operators, weighers). Air samples were also collected on the city streets and in flats. They were reference points to the results obtained. Air samples were collected at the breathing zone. The concentrations of dust, viable microorganisms (mesophilic and thermophilic bacteria, and fungi), endotoxins and the total number of microbiol cells were determined. The highest, individual exposure to dust was found in composting plant workers and waste collectors. The values exceeded considerably maximum allowable concentrations (by ten times at composting plant). The mean values for the above listed groups also exceeded the concentration of 4 mg/m3. Dust concentrations at other workposts were substantially lower. The concentrations in the city streets and in flats maintained at the level of 0.1 mg/m3. Endotoxin concentration at a protecting upper airway inflammation level (10 ng/m3) was exceeded in the majority (above 50%) of samples. That is why the average concentration in individual groups was also higher than 10 ng/m3. Street and flat samples included endotoxins at the level of 1 ng/m3. Taking as a criterion the obligatory total dust and endotoxin MAC value of 10 ng/m3 for assessing work hygiene conditions, it should be stated that waste collectors and composting plant workers were employed in conditions of poor hygiene.

Adult↗

[Hazardous health effects in communal waste collection and disposal workers].

This paper presents a review of the current literature concerning health impact of communal waste in people occupationally involved in waste collection and disposal. No studies have been as yet carried out in this regard. This review indicates that the main hazards for workers collecting and disposing communal wastes comprise organic dust with adsorbed micro-organisms, endotoxins, and numerous organic and inorganic chemicals. The major health effects associated with the job performed include injuries caused by work-related accidents and diseases. Among the most frequent diseases there are allergic and other diseases of the respiratory system, as well as musculo-skeletal, gastro-intestinal and infectious diseases. Complex hygiene assessment and control of work conditions are difficult due to the lack of hygiene standards for micro-organisms and endotoxins in the air of the workplace. No studies have been carried out thus far in Poland regarding exposure and health effects in workers collecting and disposing communal wastes. According to the information available, this problem concerns several thousands employees.

Hazardous Waste↗

Biological monitoring in waste landfills studies.

The assessment of exposure to chemicals from waste landfills and their health impact is a crucial, yet extremely difficult task in waste landfill studies. Use of biological markers, both of exposure and of health effects, may be very helpful if adequately chosen and precisely applied. They must be validated before application in risk assessment studies by establishing the relationship between the biomarker, exposure and the health outcome. Biomarkers suitable for the application in the waste landfill studies are reviewed in this paper.

Environmental Exposure↗

[Characteristics of jobs and workers employed in municipal waste collection and disposal by the city of Lodz].

Characteristics of jobs and workers engaged in the collection and disposal of waste was based on a specially developed questionnaire. Five occupational groups were selected: domestic waste collectors, waste relading workers, waste composting workers, waste sorting workers, workers at landfill sites. In addition, five job posts were selected: heavy equipment operators, waste sites workers, waste loaders, waste sorters and waste truck drivers. The analysis of characteristics revealed that among job-related burdens reported by the workers the following were found most noxious: repugnant odour, high dust concentrations, required physical effort and changing atmospheric conditions. Nevertheless, the workers in question did not claim any occupation-related illnesses or symptoms. The majority of respondents assessed their health as good or very good.

Adult↗

[Industrial wastes and health hazards].

Uncontrolled industrial waste sites are potential sources of unplanned release of hazardous substances into the environment. According to the reports of the State Inspectorate for Environment Protection (PIOS), 60% of hazardous waste sites registered in Poland create potential or real threat to public health and the environment. hazardous substances migrating off the site can spread and affect the environmental media: ground water, surface water, air, soil, biota. They can also enter the human body. As a result of research studies aimed at identifying the hazard and assessing health effects posed by hazardous waste sites in the United States, the Agency for Toxic Substances and Disease Registry (ATSDR) has identified seven groups of health effects most common among populations living in the vicinity of waste sites. These are: birth defects, cancer, immune function disorders, kidney and liver dysfunction, lung and respiratory diseases and neurotoxic disorders. However, the evidence based on exposure-effect relationship is not generally very strong. Most of the studies lack sufficiently accurate exposure assessment.

Climate↗

[Safety health conditions for disposal of waste generated during the production of barium and boron compounds].

The authors proposed an approach to calculating maximum concentrations of dust in the ambient air that may occur during digging, loading and transportation of barium and boron wastes containing a variety of metallic compounds, including arsenic and nickel. In addition, they listed conditions which should be fulfilled in view of binding legal regulations, in order to ensure that the work performed does not create any health risk. It was recognized that maintaining dust concentrations in the air below 5 mg/m3 should protected workers against the potential risk during their work.

Air Pollutants, Occupational↗

Environmental health in Europe. A WHO perspective.

Concern about public health implications of environmental conditions in countries in the European region reached high political levels, demonstrated by European ministers of health and of environment protection at their second European Conference on Environment and Health, Helsinki, 20-22 June 1994. The report "Concern for Europe's Tomorrow", prepared by the WHO European Centre for Environment and Health was a basis for endorsing by the Conference an Environmental Health Action Plan for Europe and adopting a Declaration by which the ministers committed their governments to developing National Environmental Action Plans by the year 1997. Interactions between health and environment, integrated with policies and programmes for sustainable development, provide a unifying framework for a new public health.

Environmental Health↗

Data base for risk assessment.

Health risk assessment associated with exposure to toxic chemicals is a process consisting of three basic elements: (i) hazard identification, (ii) risk estimation, and (iii) risk evaluation. Each of these elements provides a data base for making decisions regarding the control of chemical hazards for the prevention of health risk. Each of these elements involves various degrees of uncertainty, yet credibility of the management of risk requires that risk assessment be made with the highest possible accuracy and degree of confidence.

Environmental Monitoring↗

Hepatic content of free sulfhydryl compounds in animals exposed to vinyl acetate.

The content of free non-protein thiols (-SH) was investigated in the livers of guinea pigs, rats and mice after intraperitoneal injection of vinyl acetate (VA). A rapid change of the hepatic -SH level was found in guinea pigs after injection of 500 mg/kg VA. This resulted in a 50% decrease in -SH content. In mice the decrease was slower and amounted to only 23% four hours after injection of 300 mg/kg VA. Rats responded to a single dose of 450 mg/kg VA with only a 10% reduction of the -SH content of the liver. An approximately 20% decrease was observed after chronic intermittent exposure (5 h d-1 for 6 months) to 10, 100 or 500 mg/m3 VA.

Animals↗

The content of high-energy phosphates and ultrastructure of mitochondria in the brain of rats exposed to carbon disulphide.

Rats were exposed to carbon disulphide (CS2) continuously for 12 h or for 10 months, at concentrations of 2.4 mg/l air and 0.8 mg/l air, respectively. No changes in the brain content of ATP, ADP and AMP were found in rats after chronic exposure, whereas the content of ATP in the brain of rats acutely poisoned with CS2 was significantly higher (21%) accompanied by decrease in the content of ADP (10%) and AMP (45%). The biochemical changes were accompanied by ultrastructural changes of mitochondria, particularly those in the cerebellar perikaryons.

Adenine Nucleotides↗

Urinary excretion of thiodiglycollic acid and hepatic content of free thiols in rats at different levels of exposure to vinyl chloride.

In order to assess the process of oxidation and conjugation involved in biotransformation of vinyl chloride (VC), rats were exposed to 50, 200, 500, 1000 and 20,000 ppm inhaled VC. The rate of urinary excretion of thiodiglycollic acid (TDGA) after exposure to each investigated concentration of VC depends on the activity of microsomal monooxygenase. In general, higher levels of TDGA in urine were reflected by a more significant depression of non-protein sulfhydryl content in the liver of rats, whereas no changes were observed in those with inhibited activity of microsomal monooxygenase and depressed urinary levels of TDGA. The significance of alcohol dehydrogenase in the metabolism of low concentrations of VC has not been confirmed. Metabolism of VC in the range of 50--2 000 ppm is mediated by microsomal monooxygenase followed by conjugation with thiols.

Alcohol Oxidoreductases↗