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Biomedical subjects

S Tamura

Publications and source records attributed to S Tamura.

At least 937 records · Page 52Linked to original sources
PubMedDate not supplied

Gallium-67 scanning in patients with malignant pleural mesothelioma.

The findings of Gallium-67 scans in eleven patients with malignant pleural mesothelioma were reviewed and compared to those of chest CT findings. All patients had an abnormal thoracic Ga-67 accumulation. Six out of 11 showed a diffuse accumulation over the entire involved hemithorax and a localized uptake was shown in 5. A marked diffuse thickening of pleura in the absence of adequate gallium accumulation was observed in one patient. Two out of 11 had a reduction of gallium uptake after having combination chemotherapy. These results suggest that a diffusely increased uptake over the entire involved hemithorax is the most characteristic finding of Ga-67 scan in malignant pleural mesothelioma, and that Ga-67 scans may be helpful as a valuable indicator of the proper therapy. However, the superiority of Ga-67 scan to thoracic CT as a means of determining the extent of disease process could not be verified.

Aclarubicin↗
PubMedDate not supplied

A case of rheumatoid arthritis which developed after recovery from adult respiratory distress syndrome.

A 53-year-old previously healthy woman suddenly developed adult respiratory distress syndrome (ARDS) of unknown etiology. High-dose corticosteroid pulse therapy and artificial ventilation were started immediately and she dramatically responded to the treatment. However, soon after recovery from ARDS, she developed typical rheumatoid arthritis (RA). Although no apparent relationship between RA and ARDS was clear, this case is quite suggestive in the consideration of the etiology of ARDS.

Adrenal Cortex Hormones↗
PubMedDate not supplied

Recurrent Pneumocystis carinii pneumonia with long interval showing disparate radiographic findings.

A case of recurrent Pneumocystis carinii pneumonia with a long interval between episodes and each episode showing a different radiographic appearance is reported. The radiographic finding in the initial infectious episode was bilateral, patchy, alveolar infiltrate predominantly in the upper and middle lung zones and that in the second infectious episode, six and a half years later, showed bilateral interstitial infiltrate predominantly in the middle and lower lung zones. T cell immunity expressed by mitogen-induced T cell proliferation was clearly different in the two infectious episodes. These differences in radiographic appearance could be due, at least in part, to altered immunological states between the first and second infectious episodes.

Adult↗
PubMedDate not supplied

Scrotal ulcer occurring in patients with acute promyelocytic leukemia during treatment with all-trans retinoic acid.

Although all-trans retinoic acid (ATRA) has been shown to improve the outcome of patients with acute promyelocytic leukemia (APL) compared with chemotherapy alone, various adverse effects have been reported. We report here the development of scrotal ulcer in four patients with APL during ATRA treatment. ATRA 45 mg/m2 was administered orally to four patients with newly diagnosed APL, two of whom also received chemotherapy. Scrotal ulcers appeared in all four patients after a median of 22 days (range: 17-29 days) of ATRA treatment. ATRA was discontinued in only one patient, who was then treated with methylprednisolone pulse therapy. The fever resolved, and scrotal ulcer improved after this treatment. The other three patients were treated with steroid or antibiotic ointment for scrotal ulcers. ATRA was re-administered 2 years later in one patient who had relapse of APL. Ulcers appeared again on the scrotal and lower abdominal skin on day 27 of ATRA treatment. These findings strongly suggest that scrotal ulcer is a potential adverse effect of ATRA.

Abdomen↗
PubMedDate not supplied

Efficacy of all-trans retinoic acid for molecular relapse of acute promyelocytic leukemia during remission.

We analyzed the efficacy of all-trans retinoic acid (ATRA) as an early treatment for four acute promyelocytic leukemia (APL) patients in remission who were PML/RARalpha-positive by reverse transcription-polymerase chain reaction or fluorescence in situ hybridization. ATRA 45 mg/m2 was administered orally. All became negative for PML/RARalpha transcripts after 3 to 6 months of ATRA treatment. However, the PML/RARalpha transcripts subsequently reverted to positive in three cases. Although retreatment with ATRA failed to prevent hematological relapse in two patients, one case remains in hematological remission. No serious side effects were encountered during ATRA treatment. These findings suggest that early treatment of ATRA for PML/RARalpha-positive APL patients in remission may have a therapeutic benefit and prolong the duration of hematological remission without chemotherapy.

Antineoplastic Agents↗
PubMedDate not supplied

Atypical arteriographic features of myositis ossificans circumscripta (MOC).

Earlier reports on the angiographic features of MOC concluded that there may be hypervascularity and tumor stain but no A-V shunting, pooling, or vessel amputation as a result of the lesion. However, our cases demonstrated A-V shunting in MOC, and showed that the vascularity of this lesion can closely mimic that of malignant neoplasms. Therefore, the possibility of MOC should not be excluded because of the presence of A-V shunts or "tumor vessels" in suspected MOC lesion on plain radiography. These points are underscored by the findings in two MOC patients, whose cases are described.

Adult↗
PubMedDate not supplied

Contrast enhancement of cystic portions in brain tumors on delayed image of gadolinium-DTPA-enhanced MR imaging.

This report describes three patients whose cystic portions were filled with intravenously injected Gadolinium-DTPA. Four cystic portions showed contrast enhancement of the whole wall on early MR images and enhancement of the content on delayed MR images. Two cystic portions showed no enhancement of content. We speculate that the difference is based upon the composition of the cyst walls.

Adolescent↗
PubMedDate not supplied

Chromosomal analysis in Japanese couples with repeated spontaneous abortions.

Balanced chromosome rearrangements have been found at an increased frequency in couples with pregnancy wastage, especially recurrent spontaneous abortions, compared with the general population. In the present study, chromosomal analysis of peripheral blood cells, as one of the routine examinations of patients with repeated reproductive wastage, was performed on both partners of 639 Japanese couples. Among the 639 couples, 32 major chromosomal anomalies (5.0%) and 23 minor chromosomal variants (3.6%) were found. Both partners of one couple had an abnormal karyotype. The 32 major anomalies consisted of 19 reciprocal translocations, 9 Robertsonian translocations, one large inversion, two triple-X females, and one Turner mosaicism. The 23 minor variants included 15 cases of pericentric inversion of chromosome 9. The total number of pregnancies in the 54 couples with chromosomal anomalies was 181, but they resulted in only 18 normal liveborn neonates, indicating a 90.1% abortion rate. The present statistical study indicates that major chromosomal anomalies seem to be involved in repeated reproductive wastage.

Abortion, Habitual↗
PubMedDate not supplied

Aneurysm in a double velour knitted Dacron graft.

Double velour knitted Dacron grafts are currently used for aorto-iliac arterial reconstructions to increase encapsulation and enable rapid intimization of the grafts. Reports of an aneurysm arising in the body of a double velour knitted Dacron graft are rare. We experienced a case of aneurysm arising in the body of an innominate-abdominal aortic bypass graft four years after implantation. Microscopically, this focal aneurysm seemed to be related to a structural defect in the manufacturing process. We wish to stress that patients with implanted commercial Dacron prostheses should be carefully and regularly followed.

Adult↗
PubMedDate not supplied

Angiographic observations in idiopathic trigeminal neuralgia.

Twenty-four patients with idiopathic trigeminal neuralgia were treated by neurovascular decompression surgery. All patients underwent preoperative vertebral angiography. After surgery, the vertebral angiograms of these patients were retrospectively reviewed. In 23 of the 24 patients, the superior cerebellar artery (SCA) and/or the anterior inferior cerebellar artery (AICA) compressed the trigeminal nerve. In the remaining case, no such compression by vessels was observed. On review of the angiograms, most of the compressing arteries, and the sites and numbers of compression points could be identified. Most of the caudal points of the SCAs which did not compress the trigeminal nerve were located higher than the compression points of the SCAs. It was therefore concluded that vertebral angiography is useful in the preoperative evaluation of compressing arteries. Since superimposition of arteries could be avoided, the straight AP projection was the most valuable of the three projections employed.

Adult↗
PubMedDate not supplied

Non-Hodgkin's lymphomas involving Waldeyer's ring: a proposal for clinical categorization.

The clinicopathologic data of 97 patients with non-Hodgkin's lymphomas involving Waldeyer's ring were retrospectively reviewed. Age, sex, the site of involvement within Waldeyer's ring, and Rappaport's histological classification played little role in the prognosis. Although the Ann Arbor staging classification was the only factor that correlated with the patients' prognoses (stage I vs stage II, p less than 0.01; stage II vs stage III + IV, p less than 0.02), it is not considered the ideal classification. The survival rates of stage II patients, who comprised about 60% of the entire group, was quite different due to their cervical node status. That is, 33 patients with bulky cervical nodes (4 cm in diameter or more) or bilateral cervical nodes had significantly poorer survival rates than 24 patients with small unilateral cervical nodes (p less than 0.001). The survival curve of the former group was similar to that of the stage III and IV patients, whereas the survival curve of the latter group was similar to that of the stage I patients. Lymphography, which was performed for 72 patients in this series, is not considered essential. From these results, we recommend the categorization of patients with malignant lymphomas involving Waldeyer's ring into two major groups according to cervical and inguinal node status in order to assess treatment methods. That is, patients with bulky or bilateral cervical lymph nodes or those with inguinal lymphadenopathy and patients without any lymphadenopathy or those with minimal unilateral cervical nodes alone.

Adult↗
PubMedDate not supplied

Repositioning of a displaced catheter for percutaneous hepatic arterial infusion chemotherapy.

This is a report of a patient with hepatocellular carcinoma whose hepatic arterial catheter, which was introduced via a subclavian arterial branch, migrated into his right gastric artery. The catheter was successfully maneuvered to a suitable position without any further invasive procedure. The importance of preparatory embolization of the right gastric artery is underscored.

Carcinoma, Hepatocellular↗
PubMedDate not supplied

Motion related artifacts in spin-echo MR imaging: effects of sequence parameters on image quality at 1.5 Tesla.

PURPOSE: The purpose of this study was to evaluate the effects of selected parameters in a conventional spin-echo MRI sequence on image quality in a phantom undergoing periodic motion. METHODS: Images of a composite oil/copper sulfate phantom moving in a 1.5 Tesla magnet were acquired. The CuSO4 ghost signal-to-noise ratio (SNR) and distances between corresponding points on the phantom image and adjacent ghosts were evaluated. RESULTS: Increasing time to repeat (TR) and number of acquisitions (NAq) improved image quality. Ghost SNR was near unity at TR = 500 msec and at NAq around 4. Increasing TR and NAq resulted in increased distance between images. The effects of field of view (FOV) and matrix size on image quality were relatively less significant. CONCLUSION: Increasing NAq appeared to have a comparatively greater effect on ghost SNR and image quality under our experimental conditions. However, the effect of increasing NAq on image quality appeared to be definite since a saturation point was reached after a particular NAq. Increasing NAq above this point resulted in a relatively smaller improvement in image quality.

Artifacts↗
PubMedDate not supplied

A case of hepatocellular carcinoma effectively treated with epirubicin aqueous vesicles in monodispersed iodized poppy-seed oil microdroplets.

A 64-year-old woman with a solitary mass (18 mm in diameter) of hepatocellular carcinoma underwent hepatic arterial infusion therapy with water-in-oil-in-water emulsion (W/O/W) prepared by the membrane emulsification technique using a controlled pore glass membrane. In the W/O/W, numerous microdroplets of iodized poppy-seed oil (IPSO), which contained many vesicles of aqueous solution of epirubicin, were suspended in the external aqueous phase. The mean diameter of the IPSO microdroplets was 30 microns. Seventeen milliliters of the W/O/W containing 40 mg of epirubicin and 5 ml of IPSO was infused into the proper hepatic artery. No severe side effects were encountered. Computed tomography taken 3 days after the treatment revealed a clearly defined deposition of IPSO within the tumor. Serum alpha-fetoprotein levels, 5.35x10(3) ng/ml, before treatment, decreased to 131 ng/ml on 38 days after treatment. The tumor was extirpated and histopathological examination revealed complete necrosis of the tumor.

Antibiotics, Antineoplastic↗
PubMedDate not supplied

Adult cystic Wilms' tumor (nephroblastoma): radiologic features with pathologic correlation.

Wilms' tumor is an uncommon disease in adults. Wilms' tumor typically presents as a large complex mass with cystic component and varying degrees of vascularity. The previously reported radiologic findings have reflected this complex appearance. We present a case of cystic Wilms' tumor in an adult patient. The tumor presented as a large, rapidly growing, hypovascular, multicystic mass with minimal solid component which showed as septation on ultrasound, contrast enhanced CT, and MR studies. The preoperative findings were suggestive of multilocular cystic nephroma. We suggest that Wilms' tumor should be included in the differential diagnosis of a patient who presents with a large, rapidly growing, multicystic renal mass.

Adult↗
PubMedDate not supplied

Lipiodolized gelatin sponge: a simple method to make gelatin sponge radiopaque.

Gelatin sponge particles were rendered radiopaque by soaking them in small amounts of iodized oil (LP-GS). They were evaluated for their usefulness in transarterial embolization (TAE). The LP-GS particles were well visualized fluoroscopically during TAE. The duration of the opacity of LP-GS exceeded 24 hours both in vitro and in vivo. LP-GS are useful, and are an easily obtainable, radiopaque, embolic material.

Contrast Media↗