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Biomedical subjects

S Tamura

Publications and source records attributed to S Tamura.

At least 739 records · Page 41Linked to original sources
PubMed1983

Retinoblastoma in a 26-year-old adult.

Retinoblastoma in a 26-year-old woman is reported clinicopathologically, and the difficulties in this clinical diagnosis are presented. Clinical and morphologic findings of this case suggest that rare embryonal retinal cells can persist and be subject to late malignant transformation.

Adult↗
PubMed1983

Fine structural aspects on the renewal and development of surface mucous cells and glandular cells of the gastric body of the adult golden hamster.

By light and electron microscopic autoradiography using 3H-thymidine, the renewal and development of surface mucous cells and glandular cells in the gastric body were studied in normal young adult golden hamsters. The isthmus and neck regions of the gastric gland are composed of immature surface mucous cells, immature parietal cells, young parietal cells and mucous neck cells. It is presumed that the stem cell having the potency of differentiating into various kinds of cells is not present in the gastric mucosa of the adult golden hamster. Immature surface mucous cells, located in the isthmus region and capable of synthesizing DNA, contain abundant free ribosomes and a small number of secretory granules. The secretory granules increase in number as the cells ascend towards the gastric surface, forming a thick granule zone in the cell apex. The cells further contain small electron lucent vesicles which are likely involved in the formation of glycocalyx. The immature parietal cells in a low differentiated state, possessing the DNA synthesizing ability, are rarely found in the isthmus. They show collapsed intracellular canaliculi with long microvilli and contain numerous free ribosomes but smooth tubular elements are difficult to recognize. Some of the mucous neck cells located in the isthmus to neck region and capable of synthesizing DNA, are characterized by abundant free ribosomes, a few elements of rough endoplasmic reticulum relatively well developed Golgi apparatus and a few dense secretory granules. Mature surface mucous cells contain abundant secretory granules filling an apical granule zone. They are fated to be degenerated, and extruded into the gastric lumen. This is considered to be a holocrine process. The middle and basal regions of the gland consist mainly of chief cells, parietal cells and endocrine cells. A few of the chief cells in the middle part of the gastric gland also have the activity of synthesizing DNA. Some of the immature cells in the isthmus region, and mature glandular cells in the bottom of the gland are degenerated and phagocytosed by neighboring epithelial cells. This paper also records the occurrence of smooth muscle fibers in the lamina propria, extending from the muscularis mucosae to the basal part of the degenerated surface epithelium.

Animals↗
PubMed1983

[Case report of lymphangioma--a review of benign non-epithelial tumors of the pancreas].

Benign nonepithelial growths from indigenous structures in the pancreas are extremely rare. A patient with a lymphangioma of the pancreas is reported and 18 cases with benign non-epitherlial tumors reported in the Japanese literature are discussed. Of 18 tumors, 7 were hemangiogenic, 5 were lymphagiogenic, 3 were neurogenic and one each was fibromatous, leiomyomatous and teratomatus. There was no particular association with sex and age. Frequent symptoms suggesting intraintestinal hemorrhage, i.e. tarry stool, melena, occult blood, anemia.

Aged↗
PubMed1982

Production by cultured spleen cells of inflammatory substances and other lymphokines that mediate delayed-type hypersensitivity in mice.

In vitro cultivation of normal mouse spleen cells with human serum albumin generated effector cells that mediate the delayed-type hypersensitivity (DTH) reaction. The cultured cells, when incubated in a serum-free medium for a further 24 hr, released substances (FPRF) which caused a footpad inflammatory reaction at a maximum of 6 hr after injection into normal syngeneic or allogeneic strains of mice, as well as macrophage migration inhibition factor (MIF) and macrophage activating factor (MAF). The DTH-effector cells in the culture were fractionated in the low density layers by discontinuous bovine serum albumin density gradient centrifugation. The effector cells in the low density layers were further enriched in the Lyt 1 subpopulation of T cells when fractionated on a fluorescence activated cell sorter. Cells capable of producing the inflammatory substances (FPRF), MIF and MAF were also enriched in the same fraction containing DTH-effector cells. These results suggest that low density, Lyt 1-positive T cells mediating the DTH reaction produce FPRF as well as MIF and MAF.

Animals↗
PubMed1982

Percutaneous transluminal angioplasty of the popliteal artery and its branches.

Percutaneous transluminal angioplasty (PTA) of the popliteal artery and its branches was performed for relief of ischemia of the leg. Thirty-four procedures were performed in 31 patients (bilateral in 1 and repeated in 2). Angioplasty was technically successful in 29 cases (85%), with immediate clinical improvement in 26 (89%). The mean ankle-arm pressure index rose from 0.28 to 0.77. Long-term noninvasive follow-up in 23 of 26 patients with initial clinical improvement demonstrated reocclusion in 6 (2 of whom had successful redilatation) and continued patency in 13 who were followed up for 3 to 29 months (average, 11.6 mo.); the mean ankle-arm pressure index was 0.71 and the cumulative patency rate at 2 years was 57%. Six patients died, though all were asymptomatic. Since many of these procedures are performed for limb salvage in patients who would not benefit from surgery, PTA is useful in providing acute and often prolonged relief of ischaemia of the leg.

Aged↗
PubMed1982

A proteolytic mechanism for the action of insulin via oligopeptide mediator formation.

Evidence is presented that the chemical mediator of insulin action is a peptide(s) and most likely glycopeptide(s). The mediator is formed proteolytically because 1) protease inhibitors inhibit insulin action and 2) trypsin mimicks insulin action via mediator formation. Trypsin mediator does not faithfully reproduce the action of insulin mediator, which indicates that the sites of proteolytic cleavage by insulin and trypsin differ. A coordinated multivalent proteolytic mechanism by which insulin acts to trigger an external membrane-bound protease to cleave mediator from a membrane glycoprotein precursor is presented.

Animals↗