Properties of an adrenal cytochrome P-450 (P-45011beta) for the hydroxylations of corticosteroids.
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Biomedical subjects
Publications and source records attributed to S Takemori.
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The visual suppression test is one of the visual fixation tests. It is performed by recording caloric nystagmus by ENG, and the maximum slow phase velocity of caloric nystagmus in darkness is compared with the slow phase velocity in light with eyes open. Visual suppression of slow phase velocity of caloric nystagmus is 54 +/- 12% in 52 normal adults ageing from 21 to 40. Visual suppression in normal subjects is not influenced by water temperature used for the caloric test and not changed by background illumination in light. Visual suppression is stronger when the target is closer to the eyes of the subjects. The following abnormalities have been diagnosed by this test: flocculus and nodulus lesions on the side of the lesion; inferior olive lesions; parietal lobe lesions; compensation after unilateral sudden loss of inner ear function.
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Normal 38 juvenile rhesus monkeys were used to study cerebellar contribution to oculomotor function. (1) Gaze nystagmus was seen only after bilateral flocculus lesions. (2) Spontaneous nystagmus was observed after nodulus, flocculus and cerebellar nuclei lesions. (3) OKN was severely impaired after bilateral flocculus and nodulus lesions. It was slightly impaired after dentate nucleus lesions in a long-term observation. (4) It is a very interesting finding that OKN is severely impaired after destruction of the flocculus and nodulus which have a very important role in the visual fixation.
Eighteen 12- to 16-year-old patients with thalidomide embryopathy were examined otologically and neurotologically to clarify both morphological and functional ear anomalies. Ear anomalies were found in the external, middle, and inner ears. However, the inner ear, especially the vestibular portion of the labyrinth, was more extensively undeveloped both morphologically and functionally. Dysfunctions were concomitant in the oculomotor and the vestibular systems.
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