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Biomedical subjects

S Takemori

Publications and source records attributed to S Takemori.

At least 19 recordsLinked to original sources
PubMed1979

Electron paramagnetic resonance studies of the purified cytochrome P-450scc and P-45011beta from bovine adrenocortical mitochondria.

Electron paramagnetic resonance studies have been carried out on two species of cytochrome P-450 (P-450scc and P-45011beta) purified from bovine adrenocortical mitochondria. The g values of the steroid-bound cytochromes in the high spin form were determined at 4.2 degrees K to be 8.07, 3.60 and 1.70 for P-450scc and 8.00, 3.65 and 1.71 for P-45011beta. The E/D values were estimated to be 0.103 for P-450scc and 0.099 for P-45011beta. Either high spin P-450 was converted into the low spin form by the treatment with an NADPH dependent electron donating system and subsequent gel filtration in order to remove the steroid. The g values of the low spin ferric cytochromes were 2.423, 2.247 and 1.914 for P-450scc and 2.430, 2.251 and 1.919 for P-45011beta at 77 degrees K. The values for magnitude of delta/gamma, magnitude of V/gamma and k were 5.69, 5.21 and 1.11 for P-450scc and 5.94, 5.38 and 1.16 for P-45011beta. These studies indicate that there are some differences in the ferric heme environment between P-450scc and P-45011beta.

Adrenal Cortex↗
PubMed1979

Cerebral contribution to the visual suppression of vestibular nystagmus.

Thirty-two patients with cerebral lesions were examined to locate cerebral areas involved in visual suppression. Visual suppression was reduced or abolished when the lesions were in the parietal lobe, especially in the dorsoposterior region. This part of the parietal lobe seems to modify visual suppression of caloric nystagmus that is mediated by the flocculus and nodulus of the cerebellum as well as the pons. In patients with frontal lobe lesions including the parietal lobe, visual suppression was reduced or abolished. Thus, the parietal lobe is important for this visual suppression mechanism.

Adult↗
PubMed1979

Eye movements associated with eye closure. I. Normal subjects.

Eye movements associated with eye closure were studied in 36 normal adults, and they were recorded by DC amplifiers of ENG. (1) Eyes moved 64 +/- 17 degrees upward and were adducted 15 +/- 7 degrees when eyes were closed. (2) The vertical eye position was held upwards in 33 persons and slightly turned down in 3 persons. (3) The superior rectus and inferior oblique muscles worked together during eye closure.

Adult↗
PubMed1979

Eye movements associated with eye closure. II. Down turning of eye ball elevation.

DC recordings of horizontal and vertical eye movements of various neurological patients were made in an attempt to specify the mechanism underlying sustained eye ball elevation associated with eye closure. Sudden or gradual down turning of vertical eye ball elevation was seen in the following groups: (1) acute stage of inner ear hypo- or afunction; (2) lateral lesions of the cerebellum; (3) acute stage of cerebellar inflammation, and (4) some cases of cerebral lesions. The following pathway seems to be the simplest which would account for these findings: anterior semicircular canal leads to superior vestibular nucleus leads to brachium conjunctivum leads to oculomotor nucleus leads to superior rectus muscle (ipsilateral) and inferior oblique muscle (contralateral).

Adult↗
PubMed1979

The mechanism of inhibition of caloric nystagmus by eye closure.

24 normal adults and 324 clinical cases were examined, for the purpose of shedding light on the mechanism of inhibition of caloric nystagmus by eye closure. When the eyes were closed, an eye was suddenly adducted 13 +/- 5 degrees and elevated 55 +/- 11 degrees. These adductive and upward eye movements were normal responses caused by eye closure. Caloric nystagmus was inhibited by upward eye deviation. With the turning down of the vertical eye position, the caloric-nystagmus inhibition was released. During eye closure, there were four types of vertical eye-movement responses: (a) holding the eye position up, (b) fluctuation around an upward eye position, (c) gradual downward turning, (d) sudden downward turning, Types a, b and c were seen in normal subjects. However, type d was not seen in normal people.

Caloric Tests↗
PubMed1978

Visual suppression test.

The visual suppression test is one of the visual fixation tests. It is performed by recording caloric nystagmus by ENG, and the maximum slow phase velocity of caloric nystagmus in darkness is compared with the slow phase velocity in light with eyes open. Visual suppression of slow phase velocity of caloric nystagmus is 54 +/- 12% in 52 normal adults ageing from 21 to 40. Visual suppression in normal subjects is not influenced by water temperature used for the caloric test and not changed by background illumination in light. Visual suppression is stronger when the target is closer to the eyes of the subjects. The following abnormalities have been diagnosed by this test: flocculus and nodulus lesions on the side of the lesion; inferior olive lesions; parietal lobe lesions; compensation after unilateral sudden loss of inner ear function.

Adult↗
PubMed1977

Cerebellar contribution to oculomotor function.

Normal 38 juvenile rhesus monkeys were used to study cerebellar contribution to oculomotor function. (1) Gaze nystagmus was seen only after bilateral flocculus lesions. (2) Spontaneous nystagmus was observed after nodulus, flocculus and cerebellar nuclei lesions. (3) OKN was severely impaired after bilateral flocculus and nodulus lesions. It was slightly impaired after dentate nucleus lesions in a long-term observation. (4) It is a very interesting finding that OKN is severely impaired after destruction of the flocculus and nodulus which have a very important role in the visual fixation.

Animals↗
PubMed1976

Thalidomide anomalies of the ear.

Eighteen 12- to 16-year-old patients with thalidomide embryopathy were examined otologically and neurotologically to clarify both morphological and functional ear anomalies. Ear anomalies were found in the external, middle, and inner ears. However, the inner ear, especially the vestibular portion of the labyrinth, was more extensively undeveloped both morphologically and functionally. Dysfunctions were concomitant in the oculomotor and the vestibular systems.

Abducens Nerve↗