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Biomedical subjects

S Takei

Publications and source records attributed to S Takei.

81 records · Page 5Linked to original sources
PubMed1982

[Continuous recordings of the echocardiogram and electrocardiogram through the night in patients with nocturnal angina: "All-night echocardiography"].

Continuous observation of the left ventricular (LV) wall motion through the night has not been reported yet. So we developed the long-term recording system of the echocardiogram through all of the night, which was proved useful in a clinical setting. In order to record a long-term echocardiogram, a superimposed echocardiogram of each cardiac cycle was developed on the monitor television by using QRS complex as its trigger. This monitor view has a capacity to display such an echocardiogram with 2-channel electrocardiogram (ECG). Sudden changes of the cardiac motion during the recording were easily detected on the monitor view. These pictures were also recorded on the video cassette recorder through the video camera. We call this system "All-night echocardiography". Complete review of the video tape for 10 hours was possible for only 50 minutes by changing the speed of the review tape (one-twelfth of real time). A probe (Monitoring Probe) was fixed on the chest wall during the recording. "All-night echocardiograms" were recorded in eight patients for 10 hours in total 10 nights. LV posterior wall (PW) monitoring was succeeded in 3 patients for 4 nights during the anginal attack. Systolic motion of LVPW was decreased with ST elevation in a VF in the simultaneous ECG during spontaneous attack (Fig. 5).

Angina Pectoris↗
PubMed1981

Cytotoxicity of antiserum sensitized hemolytic streptococcal M protein fraction on cultured myocardial cells.

We have studied cytotoxicity of antisera of monkeys sensitized to streptococcal M protein fraction, which was prepared by the method of Lancefield et al., on cultured myocardial cells. These antisera exerted a significantly higher cytotoxic effect on the myocardial cells than normal monkey sera, and this cytotoxic effect seemed to be organ-specific. In the presence of normal monkey lymphocytes, the antisera had a cytotoxic effect on myocardial cells, but normal sera in the presence of normal monkey lymphocytes had no cytotoxic effects. These data suggest that M protein fraction of hemolytic streptococcus plays an important role in the pathogenesis of rheumatic carditis.

Animals↗
PubMed1975

A clinical method for the determination of serum gamma-glutamyl transpeptidase.

A simple, highly sensitive and reproducible method for the assay of gamma-glutamyl transpeptidase (EC 2.3.2-) activity is introduced, using gamma-glutamyl-p-nitroanilide as a substrate and glycylglycine as an acceptor in 50 g/l of polyoxyethylene nonylphenol. Serum transpeptidase activity was assayed in 1080 healthy adults, the normal mean value being 14.8 mU/ml. The diagnostic evaluation of the enzyme in various hepatobiliary diseases is also discussed.

Adult↗
PubMedDate not supplied

Treatment of collagen induced arthritis in DBA/1 mice with L-asparaginase.

OBJECTIVE: To evaluate the safety and efficacy of L-asparaginase as an immunosuppressive agent in a mouse model of rheumatoid arthritis. METHODS: Male DBA/1 mice with collagen-induced arthritis (CIA) were treated at different intervals with various doses of native and pegylated L-asparaginase from E. coli. The mice were observed for 4 weeks during which time arthritis was scored. Outcome parameters included effect on severity and progression of established arthritis as well as prevention of disease. In addition, X-rays from the affected joints were obtained for comparison. RESULTS: Both native L-asparaginase at a dose of 50 IU/injection intraperitoneally three days a week and pegylated asparaginase (PEG-L-asparaginase) at a dose of 25 IU/injection twice a week, significantly reduced the mean arthritic score (MAS) in mice with established arthritis (p < 0.001 for PEG-L-asparaginase). When native L-asparaginase was administered before the onset of arthritis (days 14-post immunization) the number of mice developing arthritis as well as the number of arthritic paws and the severity of arthritis in the treatment group were significantly decreased (p < 0.0001). Significant differences were found in the X-ray evaluation between treated and control mice. None of the animals died due to drug related events or showed signs of asparaginase induced toxicity. CONCLUSION: Our data provide the first direct evidence that L-asparaginase is a potent antiarthritic agent and may represent an effective second line agent for future treatment studies in juvenile and adult rheumatoid arthritis.

Animals↗