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Biomedical subjects

S T Huang

Publications and source records attributed to S T Huang.

At least 55 records · Page 3Linked to original sources
PubMed1991

[A dental anthropological study of Chinese in Taiwan. I). Craniofacial morphology].

The cephalometric films were collected from 30 boys and 30 girls of 12 years of age, and from 36 males and 34 females of 18 years of age; all of whom were Chinese in Taiwan, all possessed acceptable occlusion to survey the craniofacial morphology and characteristics associated with dental anthropology. Data were analysed by the computer program at the Department of Orthodontics of Japan Tokyo Medical and Dental University. Data were compared with Japanese, North American Caucasians, Central and South American Indians from papers. It was concluded that: 1) Chinese in Taiwan were similar to Japanese, Central and South American Indians, in that; all possessed a shorter frontal cranial base and depth of face, and were completely different from North American Caucasians. The direction of growth showed counter-clockwise rotation in the four Mongoloid races; however, Caucasians showed straight--down growth. The four Mongoloid races had more frontal position of A,B point and more labial inclination of anterior tooth axis than Caucasians. 2) Chinese in Taiwan were similar to Japanese, but were different from Central and South American Indians, in having a flatter infraorbital outline, longer facial height, flattened mandibular plane angle and a more frontal position of chin. 3) Chinese in Taiwan were characteristically different from Japanese by having a smaller interincisal angle, lower frontal facial height, mandibular angle and mandibular plane angle. In summary, the results indicated that Chinese in Taiwan are characterized by having a wide but short face pattern, a retroposition of the mandible ramus, a more upright mandible angle and a prominent labial inclination of anterior tooth axis.

Adolescent↗
PubMed1991

[A dental anthropological study of Chinese in Taiwan (2). Teeth size, dental arch dimensions and forms].

Both upper and lower dental study models were collected from 30 boys (12 years old) and 30 girls (12 years old) with acceptable normal occlusion to understand the characteristics of the crown size, dental arch width and length such as (1) mesiodistal diameters of crown size from central incisor to first molar, (2) the width and length of dental arch and basal arch and (3) the morphology of dental arch form. After statistical analysis, data were compared with Japanese, Central and South American Indians and North American Caucasians from papers. The results were: (1) There was no statistical difference in teeth size between males and females, except the upper first molar of males was larger than that of females, lower central incisor of males was smaller than that of females. (2) The dimensions of dental arch of males were larger than that of females in general, especially such items as width and length of basal arch. (3) The crown size of Chinese male was in generally smaller than that of four other races, especially the upper canine, lower central incisor and first molar. The crown size of Chinese females showed that although the lower first molar was smaller than that of Central and South American Indians, but the upper first premolar, lower canine and central incisor were larger than that of Japanese. Upper lateral incisor was larger than that of South American Indians. Compared to that of North American Caucasians, Chinese females had a smaller upper central incisor and a larger upper first premolar. (4) The dimensions of dental arch in Chinese were very similar to Japanese, South and Central American Indians, but wider and shorter than Central and South American Indians. (5) The superimposition of dental arch form showed that the four races of Mongoloids had similar ovoid dental arch forms.

Asian People↗
PubMed1991

Hemorrhagic disorder due to an isoniazid-associated acquired factor XIII inhibitor in a patient with Waldenström's macroglobulinemia.

A case is described of a 75-year-old woman with a history of pulmonary tuberculosis and Waldenström's macroglobulinemia who developed an inhibitor of coagulation factor XIII while taking isoniazid. The patient presented with a subcutaneous hematoma of the abdominal wall that extended from the xiphoid process to the symphysis pubis and measured 20 cm in diameter. Results of routine coagulation studies were normal with the exception of an increased solubility of the patient's plasma clot in 5M urea consistent with a deficiency of factor XIII activity. Persistence of the deficiency following a 1:2 dilution of the patient's plasma in normal plasma indicated the presence of an inhibitor. A sample of the patient's plasma was depleted of IgG by streptococcal protein G adsorption. The IgG-depleted plasma did not inhibit factor XIII activity, indicating that the inhibitory activity was not attributable to the underlying IgM paraprotein. The patient's purified IgG, on the other hand, inhibited factor XIII activity and the inhibitory activity could be neutralized by anti-IgG antibody. The patient's IgG also inhibited factor XIII-mediated incorporation of fluorescent monodansylcadaverine into casein. Binding of the patient's IgG to factor XIII concentrate was demonstrated by enzyme-linked immunosorbent assay and the IgG that bound to the factor XIII was demonstrated to be polyclonal. Isoniazid was discontinued after the patient was admitted to the hospital. Cryoprecipitate infusion controlled bleeding and reduced the inhibitor titer by 50%. Treatment with cyclophosphamide and prednisone, followed by extracorporeal immunoadsorption over a staphylococcal protein A column, did not reduce the inhibitor titer further. Plasma exchange therapy reduced the inhibitor titer to undetectable levels but failed to restore factor XIII activity. Infusions of factor XIII concentrate reproducibly restored factor XIII activity and were not associated with an anamnestic rise in the inhibitor titer. This represents the seventh reported case of an acquired inhibitor to factor XIII associated with the ingestion of isoniazid.

Aged↗
PubMed1991

Agglutination of blood cardioplegia by cold-reacting autoantibodies.

Cold-reacting autoantibodies occasionally occur in patients requiring cardiac operations. This report describes the clinical course of 1 patient with cold-reacting autoantibodies and intracoronary agglutination of the blood cardioplegia solution. Observations made in vivo and in vitro are considered in discussing recommendations for the management of extracorporeal circulation and cardioplegic arrest in patients with clinically silent cold-reacting autoantibodies.

Aged↗
PubMed1990

[Isolation and biotyping of Streptococcus mutans among preschool children in Kaohsiung city].

Strains of streptococcus mutans were isolated from the saliva of preschool children in Kaohsiung City. The unstimulated whole saliva samples were inoculated onto modified Gold's agar plates and incubated for 24-48 hours anaerobically at 37 degrees C. Strains of S. mutans were classified according to Shklair and Keene's biochemical methods and biotyped according to the methods of Farghaly et al. S. mutans could be detected in 102 (89.5%) of 114 preschool children. The most common biotype of S. mutans in single isolation was biotype I (72.9%). The percentages of the other biotypes are as follows: biotype II (5.2%), biotype III (7.3%), biotype IV (7.3%) and biotype V (7.3%). Our study revealed that the deft index was significantly higher in children who were biotype I carriers than in those who were nonbiotype I carriers. This observation suggests that biotype I may be related to the higher incidence of dental caries in our preschool children.

Bacterial Typing Techniques↗
PubMed1990

Analysis of 8-methoxypsoralen by high-performance liquid chromatography.

We report a simple and rapid procedure for assaying 8-methoxypsoralen (8-MOP) in plasma by high-performance liquid chromatography (HPLC). The standard curve for the assay is linear for 8-MOP from 15 to 500 micrograms/L (y = 0.002x-0.01, r = 0.99) with a lower limit of detection of 1.5 micrograms/L. Intra-assay precision (CV) was 6.0% at the 100 micrograms/L concentration and 10.0% at 50 micrograms/L (n = 30 each). Interassay precision was 6.4% at 100 micrograms/L and 7.0% at 50 micrograms/L (n = 50 each). Extraction recovery of 8-MOP was 98%. Common antiarrhythmics, sedatives, and hypnotics were found not to interfere.

5-Methoxypsoralen↗
PubMed1990

[Clinical, pathological and electron microscopic observation of cardiac myxoma of the right atrium].

Five cases of cardiac myxoma of the right atrium and 1 case of myxosarcoma which involved both left and right atria are reported. Clinical manifestations were palpitation, shortness of breath, systolic and diastolic murmurs at the apical or tricuspid area, etc. Evidence of right atrial enlargement was shown on X-ray film. Echocardiographic examination was highly valuable in the diagnosis of this disease. The morphology of the myxoma of the right atrium was similar to that of the left one. The former was larger and heavier than the latter. Hemorrhage and necrosis inside the tumors were usually more severe in right atrial myxoma than the left. The clinical and pathological features (gross, histological and ultrastructural) are briefly discussed. In this series, 1 case of right atrial myxoma was complicated by alveolar cell carcinoma, but the histological changes of the two tumors were totally different.

Adolescent↗
PubMed1989

[Intraoperative anaphylactic shock--report of two cases].

Allergic reactions are often unpredictable, sudden in onset and may be potentially lethal. Clinical manifestations are confined to skin (rash, urticaria, angioedema), respiratory tract (laryngeal edema, bronchospasm) and cardiovascular system (hypotension, bradycardia, dysrhythymia). Because cardiovascular collapse is the most common life-threatening clinical feature, immediate and proper treatment is necessary. We have experienced two cases of intraoperative anaphylatic shock between September 1988 and April 1989. The precipitating factors were of nonanesthetic origin (case 1 was probably due to cephalothin and case 2 was due to dextran 40). Both cases manifestated with hypotension, bradycardia, cutaneous rash and urticaria. Recovery was smooth and without sequela after volume expansion and sympathomimetic drug. We discuss these two cases with a brief review.

Adult↗
PubMed1989

[Morphological observations of collagen type I and type III in experimental liver fibrosis].

Rats receiving intravenous injection of human albumin (4 mg/rat) once biweekly developed liver fibrosis. The lesion seemed to have little relation to hepatocellular injury. The incidence of liver fibrosis increased with the length of immunization, ranging 80%-86% after 30-60 days. The whole process of experimental liver fibrosis may be divided into three phases. The first is the initial stage of fibroplasia (from the first day to the time of 15 days after start of immunization). In this phase, Ito cells were activated and collagen type I and type III began to increase. The second is the activated stage of fibroplasia (from the 15th to the 60th day after the beginning of immunization), in which collagen type I and type III reached the maximum and myofibroblasts as well as 'transitional cells' proliferated with deposition of collagen fibers. The third phase is the stage of post-fibroplasia (the period after elimination of immunization). Collagen type III diminished gradually while collagen type I remained increasing. Our findings indicated that fibroplasia occurs at the very beginning of liver injury. This suggest that treatment of liver fibrosis must be considered simultaneously with treatment of acute hepatitis.

Albumins↗
PubMed1987

Affinity labelling of E. coli leucyl-tRNA synthetase with 3'-oxidized tRNA(Leu).

The E. coli leucyl-tRNA synthetase (E.C. 6.1.1.4) was specifically labelled with 3'-oxidized tRNA(Leu) (tRNA(oxLeu)). The procedure involves a Schiff's base formation and its subsequent reduction by sodium cyanoborohydride. Stoichiometric inactivation of aminoacylation was achieved with the incorporation of 1 mol of tRNA(oxLeu) per mol LeuRS. On the other hand, the amino acid activation activity of LeuRS-tRNA(ox) complex was partially inhibited. After extensive digestion of the complex by pancreatic ribonuclease, the amino acid activation activity was fully recovered, while the aminoacylation activity was not restored at all.

Affinity Labels↗
PubMed1987

[Ultrastructural changes in atrial myxoma].

Ultrastructural changes of 20 cases of atrial myxoma were studied. Under the electron microscope, in a large amount of amorphous matrix, the myxomal cells were either scattered or aggregated. There were numerous microvilli-like cytoplasmic processes on the surface of the tumor cells. In many aspects, the ultrastructural features of the tumor cells were similar to those of the smooth muscle cells. The abundant cytoplasmic filaments were one of the most prominent ultrastructural features. Sometimes, some of them could form dense bodies. There were cytoplasmic filaments in the cytoplasmic processes of a certain tumor cells and lots of micropinocytic vesicles beneath the inner surface of the plasmic membrane. Nuclear membrane of the tumor cells often had marked indentation which was probably related to contraction of the cytoplasmic filaments. 2 of 20 lesions showed malignant characteristics. One lesion infiltrated into the atrial myocardium, and the other involved the left and right atria. It is suggested that the atrial myxoma be a true neoplasm of the atrium with potential malignant tendency. It originates from the multipotential mesenchymal tissue and differentiates mainly towards smooth muscle cells.

Adolescent↗
PubMed1987

Preleukemia in Fanconi's anemia: hematopoietic cell multinuclearity, membrane duplication, and dysgranulogenesis.

A 25-year-old male had Fanconi's anemia characterized by small stature, the onset of pancytopenia in the first decade of life, a high spontaneous breakage rate of the chromosomes, and the development of acute myeloblastic leukemia. In the preleukemic phase, marrow erythroblasts were multinucleated, and had duplicated nuclear and cytoplasmic membranes with frequent nuclear pockets and cytoplasmic vacuoles, respectively. All neutrophilic and eosinophilic granulocytes had severe quantitative and qualitative defects of granulogenesis; autophagy and nuclear pockets were also observed in the majority of granulocytic cells. Platelets had decreased granulation and extremely dilated canaliculi. Decreased titration scores with anti-I and anti-i were observed with the patient's erythrocytes and those of his clinically normal mother. The unusual morphologic and serologic findings in this patient appear to have resulted from a membrane abnormality affecting the cells of several hematopoietic lines and their organelles.

Adult↗