Biomedical subjects

S T Chandler

Publications and source records attributed to S T Chandler.

22 records · Page 2Linked to original sources

PubMed1978

The assessment of digital vessel disease by dynamic hand scanning.

A method of assessing hand and digital vessel perfusion is described. It involves an intravenous injection of Tc99m pertechnetate with monitoring of the isotope uptake in the hands and fingers by a gamma camera equipped with a small computer. The technique allows visual evaluation of the arterial supply and a means of quantifying digital perfusion. An evaluation of the technique in normal hands, in patients with digital vessel disease from vibration trauma, Raynaud's and embolism from an ulnar artery aneurysm is described. The potential of the technique in quantifying response to treatment is illustrated by sequential isotope hand scans in a patient treated for obliterative disease of the fingers.

Adult↗

PubMed1978

The noninvasive assessment of aortoiliac disease: a comparison of dynamic isotope angiology with thigh brachial pressure index.

In 41 patients with severe claudication, the time taken for an intravenously injected isotope bolus of TC99m pertechnetate to pass from the aortic bifurcation to the common femoral arteries was measured using a gamma camera and computer. This isotope transit time (ITT) then was correlated with the severity of aortoiliac disease determined arteriographically. Highly significant differences in ITT were found between normal vessels and those with minor stenosis of less than 50%, major stenosis of 50% or more, or complete occlusion. With major disease there was a longer ITT than with minor disease (P less than 0.01). ITT gave a greater degree of differentiation between disease groups than did thigh/brachial pressure index, as measured by Doppler ultrasound in the same patients, and was not influenced by superficial femoral artery occlusion.

Aorta↗

PubMedDate not supplied

Follow-up of patients with suspected venous thrombosis but negative radionuclide venography.

A retrospective review of the outcome of patients presenting to the district general hospital with suspected deep vein thrombosis (DVT) but normal radionuclide venogram. Of 387 scans, 141 (36%) were reported as positive, 81 (21%) as equivocal, and 165 (43%) as negative. The casenotes of 150 (91%) of those with negative scans were reviewed of which 124 were performed as part of the investigation of suspected DVT. During the next 3 months there were 13 DVTs and 7 with pulmonary emboli in this group, 4 of the latter proving fatal (confirmed at postmortem in 3). From a review of the initial clerking, the pre-venogram likelihood of DVT was graded as low in 54 (43%), medium in 23 (18%), and high in 45 (36%). DVT or PE occurred in none of those with a low probability, 9% of those with medium, and 38% of those with high probability. The results suggest that radionuclide venography is insufficient to exclude DVT when suspected clinically.

Adult↗

PubMedDate not supplied

Successful medical treatment of peptic pyloric stenosis: Dr Sippy revisited.

BACKGROUND: Surgery and balloon dilatation are perceived by many as the principal treatments for peptic pyloric stenosis. We questioned whether, with the availability of modern acid suppressant treatment, this was still appropriate or whether patients could be managed with medical treatment alone. METHODS: Seventeen consecutive patients with peptic pyloric stenosis were treated with endoscopic gastric drainage, followed by oral omeprazole in 15 or cimetidine in two. Gastric emptying half times for solids and liquids were assessed in 11 of the 17 patients when they had become asymptomatic. RESULTS: Endoscopic drainage and medical treatment successfully relieved symptoms in all 17 patients, although the gastric emptying studies in 11 patients still showed prolongation in eight. Symptoms resolved completely after a mean of 28 days. Five patients relapsed when changed from omeprazole to cimetidine treatment, but all responded to re-starting omeprazole. Four patients remain well on cimetidine alone. CONCLUSIONS: Medical treatment preceded by endoscopic gastric drainage was effective in all patients in this series and may be the preferred choice of treatment in patients with pyloric stenosis.

Adult↗