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Biomedical subjects

S T Anderson

Publications and source records attributed to S T Anderson.

At least 37 records · Page 2Linked to original sources
PubMed1996

Pituitary adenylate cyclase-activating polypeptide acts within the medial basal hypothalamus to inhibit prolactin and luteinizing hormone secretion.

In this study, we investigated the hypothalamic regulatory role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the control of LH and PRL secretion. Overiectomized ewes were surgically prepared with bilateral guide tubes directed at the preoptic area (POA) or medial basal hypothalamus (MBH). After recovery from surgery, PACAP38 (0.1 nmol in 2.5 microliters over 1 h) or vehicle was bilaterally infused into each site in separate trials. Infusion of PACAP38 into the POA had no effect on either LH or PRL secretion. However, infusion of the peptide into the MBH suppressed PRL secretion during the 3-h postinfusion period; the responding animals (n = 9) had injectors located in the arcuate nucleus. In the three nonresponding animals, both injectors were outside the arcuate nucleus. Mean LH concentration, LH pulse frequency, and pulse amplitude were also significantly suppressed, with LH pulsatility declining in seven of eight animals during infusion of the peptide in the MBH. These results suggest that PACAP acts in the arcuate nucleus region of the MBH, and not the rostral POA, to inhibit both LH and PRL secretion.

Animals↗
PubMed1995

T wave amplitudes in normal populations. Variation with ECG lead, sex, and age.

Consideration of increased T wave amplitude (tall T waves), either alone or in association with other electrocardiographic (ECG) parameters, may be beneficial for the early detection of acute transmural ischemia, and quantification of the increase might be used in quantifying the ischemic area. The primary purpose of this study was to quantify normal T wave amplitude limits according to ECG lead, sex, and age. One thousand nine hundred thirty-five subjects in two normal populations were analyzed, and the 98th percentile of the positive T wave amplitude for each ECG lead (including -aVR) was considered the upper limit of normal. Normal T wave amplitude was two times greater in the precordial than in the limb leads, and it was approximately 25% greater in men than in women in all leads. There was approximately a 10% decrease in normal T wave amplitude between 18-39- and 40-59-year-old patients and a 15% decrease between 40-59- and 60-79-year-old patients. The upper limit of normal T wave amplitudes identified in this study confirm those developed by Lepeschkin for use as means for each lead when age and sex are not considered. These limits might be incorporated into both normograms and automated ECG analysis systems to determine the presence or absence of tall T waves in patients presenting with symptoms of acute transmural ischemia.

Adolescent↗
PubMed1994

Panoramic display of the orderly sequenced 12-lead ECG.

The standard 12-lead electrocardiogram (ECG) has been developed over many years. The ECG has had a long and successful history of providing diagnostic information in clinical medicine. Cardiac arrhythmias have been elucidated by deductive reasoning from continuous ECG recordings with confirmation from electrophysiologic studies. Recently, there has been renewed interest in the morphology of the QRS complex, ST-segment, and T wave, which raises the important question of considering whether the usual method of display provides maximal diagnostic capabilities. The conventional display provides a logical visualization of precordial lead recordings representing the horizontal plane, but does not provide a logical visualization of the limb lead recordings representing the frontal plane. Many clinical problems require the consideration of serial ECGs necessitating the comparison of separate pages. An alternate format presenting serial recordings on a single page would be advantageous. Some automated ECG analysis systems already include the capability for multiple display formats, but these have not yet been widely used in clinical practice. This point of view paper introduces a new display format for the standard 12-lead ECG that includes: (1) a presentation of an orderly sequence of leads to facilitate scanning through different points in space and (2) a presentation of recordings of 12-lead sequences to facilitate scanning through different points in time. This display format could either replace or supplement the conventional ECG format.

Arrhythmias, Cardiac↗
PubMed1993

Systemic lupus erythematosus in a rhesus macaque.

We describe the clinical course and histopathologic findings in a rhesus macaque (Macaca mulatta) which developed a systemic inflammatory disorder resembling systemic lupus erythematosus (SLE). The manifestations of the SLE included antinuclear antibody, hemolytic anemia, membranoproliferative glomerulonephritis, and arthritis. To our knowledge, spontaneously occurring SLE has not previously been described in nonhuman primates.

Animals↗
PubMed1993

Rheumatologic disease among Air Force recruits: a multimillion-dollar epidemic.

A retrospective analysis of medical discharge diagnoses of Airmen Basic undergoing basic military training in the Air Force for a 1-year period from 1990 to 1991 was performed. The weighted variable cost to replace each recruit discharged was then used to estimate the cost to the Air Force attributable to rheumatologic disease. Musculoskeletal disorders were found to account for 67% of medical discharges, costing the Air Force at least 2.70 million dollars during the period under study. The patellofemoral syndrome, pes planus deformity, and low back pain were the most frequently encountered diagnoses.

Female↗
PubMed1992

Eosinophilic fasciitis in a rhesus macaque.

Eosinophilic fasciitis (EF) is an inflammatory disorder in the category of scleroderma-like connective tissue diseases. There are no animal models for spontaneously occurring EF. We present the case of a rhesus macaque (Macaca mulatta) with clinical, laboratory, and histologic features of EF.

Animals↗
PubMed1992

The importance of medical records to patient accounting.

Medical record processing delays can be significant and costly for hospitals. As hospitals seek to enhance financial performance through improved billing processes, medical record department functions should not be ignored. These functions can affect the financial performance of the institution in many ways. Successful hospitals will be those that actively manage these functions and integrate them with the billing process.

Accounting↗
PubMed1991

Coronary artery to middle cardiac vein fistula following endomyocardial biopsy in a heart transplant patient.

Coronary artery fistulas draining directly into the right ventricle have been recognised as a complication of transvenous endomyocardial biopsy procedures performed in heart transplant recipients. We report a case where a fistula drained into the middle cardiac vein and outline the possible mechanism of occurrence and its prevention. The diagnostic and therapeutic aspects of these "acquired" fistulas are reviewed.

Adult↗
PubMed1991

Normalization of left ventricular ejection fraction following resection of pheochromocytoma in a patient with dilated cardiomyopathy.

Catecholamine-induced cardiomyopathy associated with pheochromocytoma is a well-recognized but rare entity. Both hypertrophic and dilated variants have been described. We report a case of dilated cardiomyopathy associated with a benign pheochromocytoma that showed complete normalization of left ventricular systolic function following removal of the tumor. Serum noradrenaline and dopamine were significantly elevated without elevation in serum adrenaline levels. This may be the first report in which radionuclide ventriculography was used to document the time course of normalization in LVEF following removal of a pheochromocytoma.

Adolescent↗
PubMed1991

Rheumatoid-like arthritis in a lion tailed macaque.

Very few satisfactory models of rheumatoid arthritis (RA) exist in nonhuman species. It is particularly striking that nonhuman primates have only rarely been described to have disease processes resembling classic RA seen in humans. We describe the case of a lion tailed macaque (Macaca silenus), housed at the National Zoological Park in Washington DC, that had a polyarticular inflammatory arthropathy resembling RA. Gross and histopathologic examination of necropsy tissues and radiographic findings strongly suggest a rheumatoid-like disease, never before described in this species.

Animals↗
PubMed1990

Cardiac failure. Current therapeutic concepts.

Reflection on basic mechanisms in cardiac failure gives an insight into the modes of therapy available in management. Therapeutic options have in the past two decades expanded markedly with enhanced quality and quantity of life. With end stage disease the option of a heart transplant is providing quality of life to increasing numbers of selected patients.

Heart Failure↗
PubMed1988

Hospitals can improve cash flow by managing preauthorizations.

Managing third-party requirements for payment is becoming increasingly complex. Specifically, preauthorizations and other utilization control features have greatly affected how both physicians and hospitals deal with insurance companies and other third-party payers. Providers that can effectively and efficiently manage the preauthorization process have the opportunity to transform an administrative burden into a competitive advantage.

Accounting↗