Biomedical subjects

S Svacina

Publications and source records attributed to S Svacina.

At least 73 records · Page 4Linked to original sources

PubMed1989

[The effect of a low-energy protein diet in short-term ambulatory treatment of obese women].

Fourteen obese women (BMI 37.2 +/- 7.3) were treated with a very low energy diet containing 1555 kJ (370 kcal) for 14 days. Weight loss occurred in all cases (4.2-10.7 kg, mean 6.46 +/- 1.68 kg), although usual weight-reducing regimens have not succeeded before. There were no complications and results of usual biochemical tests did not change. Body mass index and concentrations of serum total cholesterol decreased significantly, insulin levels fell in the first and fourth hour of a glucose tolerance test. Also serum triiodothyronine concentrations declined significantly but not below the lower limit of normal results. We concluded that short-term very low energy diet treatment enable a safe decline of excessive body mass in out-patients, including those resistant to usual reducing diets.

Adult↗

PubMed1989

Use of euglycaemic clamping in evaluation of diazoxide treatment of insulinoma.

The use of diazoxide in patients with insulinoma has been evaluated using the euglycaemic clamp technique. There was significantly reduced mean tissue sensitivity to insulin, expressed as the ratio of glucose disposal rate to serum insulin concentration (M/I), in untreated patients compared to the control group. The metabolic clearance rate of insulin (MCRI) was reduced in the patients before treatment in comparison with the controls. The administration of diazoxide (Proglicem1) for three days (3 mg.kg-1 per day) caused a fall in serum insulin concentrations, together with an increase in the metabolic clearance rate of insulin and increased tissue sensitivity to insulin.

Adenoma, Islet Cell↗

PubMed1989

[Energy support with parenteral nutrition in patients with chronic intestinal inflammation].

Parenteral nutrition (PN) was administered to 24 patients with chronic enteritis. Their mean age was 37 years (range 17 to 69 years). Seventeen times Crohn's disease was involved, five times ulcerative colitis and twice postprandial enteritis. The mean period of PN was 24.6 +/- 12.9 days and its energy value was 7.79 +/- 1.63 MJ/24 hours. Some patients had a restricted oral intake, on average 5 MJ/24 hours. The energy output at rest assessed by indirect calorimetry was 7.62 +/- 1.06 MJ/24 hours. Along with PN the patients had aimed antiinflammatory treatment. In the majority of patients clinical improvement was recorded. The nutritional status improved in 13 patients, was not affected in 9 and in two it deteriorated. The improvement of the nutritional status was not always associated with regression of manifestations of the local enteritis. In particular affections of the rectum in Crohn's disease were resistant to treatment and the position changed after a derivation stoma operation.

Adolescent↗

PubMed1988