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Biomedical subjects

S Sutinen

Publications and source records attributed to S Sutinen.

At least 73 records · Page 4Linked to original sources
PubMed1980

Ultrastructure of terminal respiratory epithelium and prognosis in chronic interstitial pneumonia.

Following acute damage, proliferation of granular pneumocytes with subsequent transformation into membranous cells is the basic pattern of repair of the alveolar epithelium. Regarding chronic interstitial pneumonias little is known about the ultrastructural changes of terminal respiratory epithelium and their clinical significance. We studied open lung biopsies from 10 patients showing clinical and light microscopic changes consistent with chronic idiopathic interstitial pneumonia (UIP). We studied the ultrastructure and correlated it with the clinical course of the patients. Only alveolar type epithelium was seen in two cases with a short duration of disease and good response to therapy. Bronchiolar-type epithelium was present in the terminal respiratory units of all other patients with longer duration of disease and less favourable prognosis. Four patients died: all of them showed signs of mucus secretion and keratinization in the terminal respiratory epithelium. Thus in chronic interstitial pneumonia the presence of the alveolar type of epithelium seems to indicate reversibility and that of the bronchiolar type irreversibility of the lesions, while mucous and keratinizing metaplasias apparently occur at a late stage of the disease.

Adult↗
PubMed1979

Amount and distribution of fume contaminants in the lungs of an arc welder post mortem.

This study describes various post-mortem examinations of the lungs of a shipyard arc welder. These investigations comprised morphological methods, including gross pathology and radiography, histological and ultrastructural examinations, chemical analysis of lung tissue, and sensitive magnetic measurements, which can now be used to detect magnetic contaminants, such as welding fume, in human tissue. Such methods can also show the distribution of contaminants. The amount of welding-fume contaminants was low, only 110 mg. The contaminant iron seemed to represent only 10% of the total iron chemically analysed in lung tissue. The concentration of the total iron was 4-10 times higher than that in control tissue. Contaminants tended to collect in the central areas of the lungs. Two concentration centres could be observed in each lung, one anterior and one posterior. There was slight fibrosis around pigmented areas. Histological findings were similar to those of previous studies. Transmission electron micrographs showed that enlarged lysosomes of macrophages contained electron-dense granules, 450 nm to less than 5 nm in diameter, which formed aggregates and short chains, and resembled welding-fume particles in the breathing zone. Our results show the value of studying the same material by a number of inter-related methods.

Adult↗
PubMed1979

Post-mortem inflation, radiography, and fixation of human lungs. A method for radiological and pathological correlations and morphometric studies.

A method is described for correlative radiological and pathological studies of the lung post mortem, including radiography after air inflation, fixation with formalin-polyethylene glycol-alcohol solution, air drying and systematic histological sampling of lung tissue. For morphometric studies the total lung capacity during life is determined from radiograms and compared with the volume of the excised lung after fixation. The method is simple, relatively inexpensive, and with some experience gives good results both in radiography and histology. With this method the test lungs seemed to assume during fixation a fairly constant volume, a little higher than functional residual capacity.

Aged↗
PubMed1977

Calcium microemboli and microfilters in valve operations.

Fatal microemboli occurred in 3 of 100 consecutive patients having aortic valve replacement; 2 occurred during perfusion before the microfilter era, and 1 occurred intraoperatively despite the use of in-line filters. In all 3 patients cerebral symptoms were present immediately postoperatively, and each died of severe brain damage. On postmortem examination cerebral calcium microemboli were verified in only 2 patients, although the brain of each patient contained minute infarctions. However, calcium particles were found in the kidneys of all 3 patients. Thus the kidneys proved to be the best place for detection of calcium emboli on postmortem examination. Although the microfilters currently available effectively prevent microemboli during extracorporeal circulation, the surgeon should be aware that embolization can also occur immediately after discontinuation of perfusion. The means of protecting the patient from this are discussed.

Aortic Valve↗
PubMed1977

Ultrastructure of lymphoid interstitial pneumonia: virus-like particles in bronchiolar epithelium of a patient with Sjögren's syndrome.

Ultrastructural studies of an open lung biopsy of a patient who had lymphoid interstitial pneumonia, Sjögren's syndrome, and a highly elevated level of immunoglobulin M in the serum disclosed the presence in bronchiolar epithelium of numerous round electron-dense particles 70-120 nm in diameter. These were closely reminiscent of the oncogenic type-A viral particles associated with tumors of laboratory and wild mice. In the inflammatory infiltrate the morphology of some small lymphocytes was suggestive of germinative activity, although no germinal centers were found. Plasma cells, which were numerous in the vicinity of the bronchiolar epithelium, contained varying amounts of electron-dense material, probably immunoglobulin, which was also deposited in the irregulary thickened epithelial basal lamina. The observations support the theory that viral infection may be the stimulus to the immunologic abnormalities observed in patients with lymphoid interstitial pneumonia and Sjögren's syndrome.

Bronchi↗
PubMed1977

Acquired tracheobronchomalacia.

In a series of 2150 patients subjected to bronchoscopy 94 (4.5%) were found to have tracheobronchomalacia. Tracheomalacia alone was diagnosed in 21 patients (22%), tracheobronchomalacia in 59 (63%) and bronchomalacia alone in 14 (15%). Mild malacic changes were noted in 44 patients (47%), moderate in 38 (40.5%) and severe in 12 (12.5%). The main symptoms were dyspnoea (63%), chronic cough with expectoration (49%) and haemoptysis (33%), and the most frequent concurrent diseases chronic bronchitis (53%), bronchial cancer (27.5%) and pulmonary tuberculosis (19%). Bronchoscopy performed under local anaesthesia enabled the dynamics of the tracea and bronchi to be observed during spontaneous breathing and during coughing, and it is the best available diagnostic procedure. Histologically the number of longitudinal elastic fibres in the pars membranacea was clearly reduced throughout the whole tracheal area in one patient with tracheomalacia but no differences were found in the amount of collagen, mucopolysaccharides and elastin in the cartilages of trachea and bronchi. This disease seems to be associated with chronic obstructive pulmonary diseases such as chronic bronchitis, and it apparently shares the same aetiological factors.

Aged↗
PubMed1976

Spontaneous rupture of liver tumours.

Five geriatric patients with spontaneous rupture of the liver caused by hepatic malignancies were operated upon without mortality. Liver resection seems to be the treatment of choice, but in selected cases with unresectable tumours ligation of the hepatic artery alone is preferable to an attempt to control haemorrhage by packing and suture.

Aged↗
PubMed1976

Benign cartilagenous tumour of the temporomandibular joint.

An unusual case of a benign cartilagenous tumour of the temporomandibular joint is presented. The difficulties encountered in histological diagnosis, the benign behaviour of the tumour and the need for restraint in treatment are emphasized.

Adult↗
PubMed1976

Radicular symptoms in tuberculosis. A case report.

A case of tuberculous radiculitis in the lumbosacral region resulting in flaccid paresis of the lower limbs is presented. The primary site of tuberculosis was the intestine. Hematogenic dissemination resulted in organ tuberculosis of the third lumbar vertebra and left kidney. The infection spread locally into the lumbosacral dura and nerve roots. A decline in general immunological resistance lead to fatal dissemination of the disease into the meninges, lungs, liver, left adrenal and right kidney. Differential diagnostic problems, especially the Guillain-Barré syndrome, are discussed.

Aged↗
PubMed1975

Tuberculosis of the cervical lymph nodes : a clinical, pathological and bacteriological study.

Biopsies taken from the lymph nodes of 59 consecutive patients with cervical lymph node tuberculosis were examined bacteriologically and histologically. The series consisted of 18 men (mean age 40 years) and 41 women (mean age 46 years). Mycobacteria were isolated from 41 specimens (69 per cent), M. tuberculosis from 40 patients and a mycobacterium of the M. avium-M. intracellulare complex from one. All the M. tuberculosis strains were sensitive to streptomycin, isoniazid and PAS. No mycobacteria were isolated from the biopsy specimens of the 10 patients who had received anti-tuberculosis drug previously. Mycobacteria were isolated equally often from caseating and non-caseating lymph nodes. In 10 specimens acid-fast bacilli could be demonstrated by staining, but attempts at isolation were unsuccessful. Nine of these 10 patients had been treated with anti-tuberculosis drugs previously. Histological examination of the specimen from which a growth of 'atypical' mycobacteria had been obtained failed to show any distinctive features. The results of treatment are given over a follow-up period of 2 years. Primary chemotherapy was not entirely successful. Of 52 patients treated in this way only 38 responded well. By contrast 19 patients were treated by a combination of chemotherapy and surgery and the outcome was satisfactory in all but one.

Adult↗