Cognition. Parallel distributed processing.
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Cognition↗
Biomedical subjects
S Sutherland
Publications and source records attributed to S Sutherland.
Procedural burn pain intensity under conditions of varying physical control by the patient.
Ten adult patients hospitalized as a result of major burn injury participated in a study that used a single-subject, repeated reversal design in which subject-reported pain during patient-performed washing was compared with subject-reported pain during nurse-performed washing. Analysis, by repeated-measures ANOVA, of verbal numeric pain scores obtained at regular intervals intraprocedurally, indicated that each of the 10 subjects experienced significantly less pain under the condition of patient-performed washing compared with the condition of nurse-performed washing (p < 0.001 through p < 0.05). The quality of washing did not differ significantly (p < 0.05) between conditions, nor did the amount of opioid medication administered (p < 0.05). Results support the active participation of patients with burn injuries in their dressing changes.
Activities of Daily Living↗
Risk of recurrence after treatment of first-episode genital herpes with intravenous acyclovir.
To determine whether intravenous acyclovir treatment for a first episode of genital herpes could prevent or reduce subsequent recurrences, we combined and analyzed the results of two independently conducted, randomized, double-blind, placebo-controlled studies. Sixty-one patients were enrolled in the two trials; 30 received the drug, and 31 received placebo. At entry the demographic, epidemiologic, and clinical features of acyclovir- and placebo-treated patients from the two centers showed no significant differences. The median time to the first recurrence and the frequency of recurrences showed no significant differences when acyclovir and placebo recipients infected with either herpes simplex virus type 1 (HSV-1) or herpes simplex virus type 2 (HSV-2) were compared. However, irrespective of treatment, the median time to the first recurrence was significantly longer (293 days vs. 69 days; P less than .02) and the frequency of recurrence significantly less (0.11 recurrences per month vs. 0.43 recurrences per month; P less than .01) among patients with HSV-1 infection as compared with those who had HSV-2. It is concluded that in patients with first-attack genital herpes, the type of HSV is the most important determinant of subsequent recurrences and that intravenous acyclovir has little effect on subsequent recurrences.
Acyclovir↗