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S Suster

Publications and source records attributed to S Suster.

193 records · Page 11Linked to original sources
PubMed1986

Trabecular carcinoma of the skin simulating metastatic disease.

A case of trabecular carcinoma of the skin that resulted in prequarter amputation of the arm for local tumor aggressiveness is presented. The tumor was originally diagnosed as metastatic, most probably neuroblastoma, leading to inadequate local resection that resulted in recurrence with extensive regional nodal metastases. The importance of recognizing trabecular carcinoma as a primary tumor of the skin with a potential for recurrence and metastasis is underscored, primarily since initial total excision with adequate margins of resection has proven in most instances to be curative.

Adenocarcinoma↗
PubMed1986

Familial atrophie blanche-like lesions with subcutaneous fibrinoid vasculitis. The Georgian ulcers.

Atrophie blanche is an uncommon condition characterized by the development of white atrophic patches of skin on the lower extremities, which form as a result of fibrinoid vasculitis of superficial and mid-dermal vessels followed by necrosis and ulceration of the epidermis. We report four cases in which similar lesions developed on the legs and ankles of young Jewish Russian immigrants to Israel. Although the lesions share many features with atrophie blanche, they differ in their early age of onset, the male predilection, and the extension of the fibrinoid vasculitic process into the subcutaneous tissue. Additionally, the peculiar population clustering (Georgia, U.S.S.R.), common ethnic background, and a family history of similar lesions in close relatives seem to point to a familial or genetic predisposition underlying the development of the disease.

Adolescent↗
PubMed1986

Effects of Solcoderm.

The effects of treatment and depths of penetration of a 5-fluorouracil and salicylic acid preparation (Solcoderm) were studied in 24 patients treated for basal cell carcinoma with this compound. Two thirds of the patients in our study showed islands of residual tumor in the dermis following treatment, whereas total disappearance of the tumor was observed in one third. The depth of the fibrotic changes induced by the drug varied from 0.34 to 0.40 cm for the morphea type of basal cell carcinoma and from 0.52 to 0.88 cm for the conventional types. It is recommended that treatment with this compound be reserved only for superficial basal cell carcinomas and that it be avoided altogether in basal cell carcinomas of the morphea type.

Acetates↗
PubMed1985

Erysipelas. Changing faces.

A retrospective study of 526 adult patients admitted to the Sheba Medical Center for treatment of erysipelas during the period 1972-1982 showed a steady increase in the number of cases admitted as well as a striking change in its classical pattern of distribution, with 86% of the lesions occurring in the lower extremities opposed to 5.9% in the face. Local trauma and superficial abrasions were identified as the major predisposing factors, whereas upper respiratory tract infection was almost negligible among the patients. Peripheral vascular disease, diabetes, and prolonged treatment with corticoids, immunosuppressants, or radiation were less frequently associated with the development of the disease. New trends were also observed for the age groups and seasonal distribution of the population studied.

Adolescent↗
PubMed1985

Trabecular carcinoma of the skin. A histopathological study of two cases.

The first two cases of trabecular carcinoma of the skin reported in Israel are presented. On light microscopy, the tumors demonstrated a distinctive trabecular pattern, with cords of tumor cells embedded in the connective tissue stroma in the dermis. Dense-core neurosecretory granules, in association with formed desmosomes, were demonstrated by electron microscopy. This tumor may be misdiagnosed as lymphoma or metastatic anaplastic carcinoma, and awareness of its distinctive morphological features is necessary in order to arrive at the correct diagnosis.

Adenocarcinoma↗
PubMedDate not supplied

Inflammatory fibroid polyp of the small intestine: ultrastructural and immunohistochemical observations.

The ultrastructural and immunohistochemical features of a primary tumor of the ileum showing the classic histologic features of an inflammatory fibroid polyp (IFP) of the gastrointestinal tract are presented. Ultrastructurally the proliferating cells showed a combination of fibroblastic and histiocytic features, with abundant rough endoplasmic reticulum and active production of collagen in many of the cells and long, dendritic cytoplasmic projections with large cytoplasmic vacuoles containing remnants of phagocytosed cellular debris in others. Immunohistochemical studies showed strong cytoplasmic positivity in the proliferating cells with vimentin antibodies and scattered positivity with muramidase. Additional findings include the ultrastructural demonstration of oligocilia and occasional primitive intercellular junctions. The findings in this case suggest that IFP may represent a proliferation of primitive submucosal stromal cells exhibiting incomplete fibrohistiocytic differentiation.

Aged↗
PubMedDate not supplied

Amphicrine medullary carcinoma of the thyroid with luminal differentiation: report of an immunohistochemical and ultrastructural study.

A case of amphicrine medullary carcinoma of the thyroid is presented. The patient was an 18-year-old female with nonhereditary MEN IIb, submucosal neuromas in the oral cavity, and a thyroid tumor that metastasized to regional lymph nodes. Histologically the thyroid tumor was composed of polygonal cells arranged in a solid/trabecular pattern admixed with mucus-producing goblet cells and displaying focal cytoplasmic lumen formation. Immunohistochemical stains were positive for calcitonin, carcinoembryonic antigen, and chromogranin. Electron microscopy demonstrated C-cells containing neurosecretory granules as well as intestinal-type microlumina. The presence of goblet cells and intestinal-type microlumina in medullary carcinoma of the thyroid is reminiscent of amphicrine tumors of the gastrointestinal tract and supports the hypothesis that the parafollicular C-cells of the thyroid may be of endodermal derivation.

Adolescent↗
PubMedDate not supplied

Placental intravillous accumulation of sulfated mucosubstances. A reevaluation of so-called hydropic degeneration of villi.

A histochemical study was performed on 46 placentas showing so-called hydropic degeneration of villi. The 46 cases included early abortuses (35 cases), incomplete moles (four cases), and complete hydatidiform moles (seven cases). All the specimens showed diffuse, positive staining of the distended villous stroma with alcian blue at pH 1.2 and 2.5 in the areas containing "hydropic changes." The alcian blue positivity was abolished following digestion with hyaluronidase. These findings indicate that so-called "hydropic degeneration of villi" represents an intravillous accumulation of strongly sulfated mucosubstances rather than the result of the accumulation of water. The intravillous accumulation of mucosubstances most likely represents a nonspecific stromal reaction of the connective tissue of the placenta to a variety of noxious stimuli. This finding may have some bearing on the interpretation of the physiologic mechanisms involved in placental villous distention, which has been largely centered in the past on the premise that the villous swelling was related to hemodynamic alterations caused by the accumulation of water.

Abortion, Spontaneous↗
PubMedDate not supplied

Artifactual distortion of cells simulating metastatic small cell carcinoma in the bone marrow.

Artifactual distortion of hematopoietic elements in histologic preparations and smears of bone marrow aspirates simulating metastatic small cell carcinoma has been recently described. The clinical, pathologic, and immunohistochemical features in 12 such cases have been studied by us. In all these cases, bone marrow smears and histologic sections showed multiple small clusters of atypical, hyperchromatic cells suspicious for metastatic small cell carcinoma. Immunohistochemical stains showed focal positivity of the suspicious cells for leukocyte common antigen (LCA), anti-hemoglobin A (Hem A) and anti-erythrocyte membrane antigen (ERM), and negative staining for epithelial membrane antigen (EMA) and neuron specific enolase (NSE). Clinical follow-up of two years did not demonstrate any evidence of a primary small cell carcinoma in the lung or elsewhere. Comparison of these 12 cases with four cases of transbronchial biopsy-proven metastatic small cell carcinoma to the bone marrow showed that this artifact had a tendency to be located at the periphery of the marrow particles, unlike the true metastatic carcinoma cells which were predominantly found within the marrow particles and replacing the hematopoietic elements. The results of our immunohistochemical studies appear to indicate that these cells correspond to aggregated nuclei and cytoplasmic remnants from erythroid as well as myeloid and lymphoid cells. The main importance of identifying this artifact lies in avoiding confusion with metastatic small cell carcinoma, a distinction that may be very difficult to establish on morphologic grounds alone. Immunohistochemical stains and a thorough clinical follow-up are necessary for arriving at the correct diagnosis.

Adolescent↗
PubMedDate not supplied

Clear nuclear changes in Hashimoto's thyroiditis. A clinicopathologic study of 12 cases.

Histologic sections of thyroid glands resected from 12 patients with Hashimoto's thyroiditis have been studied in which areas were present showing clear nuclear changes such as those seen in papillary carcinoma. The patients' ages ranged from 28 to 78 years (mean = 57.3); 11 were women and one was a man. The lesions presented as focal, ill-defined areas displaying clear nuclear changes of the cells within otherwise well-circumscribed adenomatous nodules, or as small clusters of cells showing the characteristic clear nuclear features randomly admixed with the Hashimoto's elements. Histologically, the lesions were characterized by a range of nuclear features that included optically clear nuclei, prominent cytoplasmic invaginations with intranuclear cytoplasmic inclusions, and occasional nuclear grooves. In two cases, focal papillary formations were seen that were lined by cells with optically clear nuclei. In two other cases, well-circumscribed nodules bearing the architectural features of trabecular hyalinizing adenoma with focal clear nuclear changes were also present. In three cases, small (< 0.5 cm) well-circumscribed nodules bearing cytological features indistinguishable from those of microscopic papillary carcinoma were also present in addition to the areas of clear nuclear change. Follow-up of 1.5 to 19 years (mean = 9 years) showed no evidence of recurrence or metastases in any of our patients. Our study appears to indicate that thyroid follicular epithelium in patients with Hashimoto's thyroiditis may exhibit a range of clear nuclear changes similar to those encountered in papillary carcinoma. Such changes may represent another form of response of follicular epithelium to the underlying autoimmune process with possible premalignant connotation. However, they should be interpreted in context with the rest of the findings within the involved gland to avoid an overdiagnosis of malignancy.

Adult↗