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Biomedical subjects

S Suonio

Publications and source records attributed to S Suonio.

34 records · Page 2Linked to original sources
PubMed1982

Intrauterine hypoxia as a cause of hearing impairment in children.

Among more than 10,000 mothers giving birth during 1974-1977, there were 20 known cases of severe placental insufficiency in connection with hypertensive disease during pregnancy. Well-documented signs of intrauterine hypoxia were observed in all the cases. In 50% of the fetuses intrauterine growth retardation was found to be below the 10th percentile curve. In most cases the baby was delivered by means of a caesarean section. The hearing level of these infants was examined at the age of 2-5 years. In these 20 children there were no signs of sensorineural hearing loss; however, because of the size of the population, the conclusions drawn from this thorough work must be tentative. It seems that with good maternity care and thorough treatment hearing loss due to intrauterine hypoxia can be prevented.

Acoustic Impedance Tests↗
PubMed1980

A longterm isotope renography follow-up of patients following pregnancy complicated by pre-eclampsia and hypertension.

61 patients were studied with the renography and urography during puerperium ten years ago and now again. The technique and analyses were identical. The results showed that some of these parameters (SV, K, and T 1/2) were either decreased or prolonged more than ten per cent during this period in nearly all cases. However, these changes occurred in both the normal and complicated groups without any correlation with the original diagnosis from the first study. Hypertension has developed in 10 per cent of the toxemic group.

Female↗
PubMed1978

Maternal circulatory response to a single dose of ritodrine hydrochloride during orthostasis in normal and hypertensive late pregnancy.

Placental blood perfusion, the maternal heart rate, and arterial blood pressure were measured before and after a single intramuscular dose of ritodrine hydrochloride during orthostasis in 11 healthy pregnant women, 10 pre-eclamptic patients, and 11 pregnant patients with essentially hypertension. There was a slight increase in placental blood perfusion in the healthy subjects and a significant rise in the pre-eclamptic patients and the women with essential hypertension. The heart rate increased significantly in all groups. No greater changes in the systolic and diastolic blood pressures were observed. The clinical significant of the results is discussed briefly.

Blood Pressure↗
PubMed1977

A method for the assessment of placental blood perfusion using 99mTc pertechnetate.

A radioisotope method was developed for the measurement of placental blood flow using 99mTc pertechnetate as a tracer and a single detector as a measuring device. The results are given as placental perfusion rate (ml/min/ml) calculated from the tracer-appearance curve. The series consisted of 148 healthy pregnant women between the 28th and 42nd week and fifty pregnancies with a hypertensive disease. In healthy subjects the placental perfusion rate increased by about 32% in the period between 28th and 38th week, but there was a large variation. The perfusion rate showed a tendency to diminish at term. In a group of fifty hypertensive pregnancies a highly significant decrease in the perfusion rate was observed when compared with normal subjects. The conclusion drawn is that this method can be used for the quantitative measurement of placental blood supply.

Adult↗
PubMed1976

Ritodrine hydrochloride induced cardiopulmonary and placental hemodynamic changes in normal and hypertensive late pregnancy.

Cardiopulmonary parameters (minute volume, heart rate, stroke volume, right heart, pulmonary and left heart blood volumes), blood pressure and placental blood flow were evaluated in 20 normal patients, nine patients with preeclamptic disease and 12 with essential hypertension in late pregnancy before and 60 minutes after a single i.m. dose of 10 mg of ritodrine hydrochloride. The drug caused a statistically significant increase in heart rate in all the patient groups, while the systolic and diastolic blood pressures were only slightly affected. Minute volume was unchanged in the group of normal patients, but in both hypertensive groups there was a significant increase. The placental perfusion index was statistically nearly significantly decreased in the group of uncomplicated pregnancies, statistically significantly increased in preeclamptic patients, and not affected in the group with essential hypertension. Ritodrine hydrochloride medication can be expected to have a positive effect on placental blood flow only in preeclamptic disease, and then probably in the milder forms of the disease.

Female↗
PubMed1976

Numerical analysis of cardiopulmonary blood volumes in 113In(m) radiocardiography.

A theory of streamline flow of a viscous liquid was applied to the calculation of cardiac and pulmonary parameters (minute volume, stroke volume, right heart, pulmonary and left heart blood volumes) in a radiocardiographic model based on the modified gamma function. The practical feasibility of the formulations was tested using a physical flow model. The cardiopulmonary blood volumes measured from 14 normal subjects were consistent with the results obtained by more complex techniques. The present method is manageable on a small computer and is well suited to clinical routine use in connection with standard single detector 113In(m) radiocardiography.

Adolescent↗
PubMed1976

Effect of the left lateral recumbent position compared with the supine and upright positions on placental blood flow in normal late pregnancy.

The placental blood flow was assessed by the 99mTc accumulation method in 10 normal pregnancies in the left lateral recumbent position accomplished by a 15 degree wedge and in the supine position. The postural change caused a 17% decrease in the mean placental accumulation rate, which was not statistically significant. Ten patients were moved from the left lateral recumbent position to the upright position, which caused a statistically significant 23% decrease in the mean accumulation rate. Other haemodynamic variables studied were the maternal heart rate and the systolic and diastolic blood pressures. The clinical significance of the haemodynamic changes produced by alterations in posture are briefly discussed.

Adult↗
PubMed1976

Determination of placental blood flow by external monitoring of 113In.

A simple and noninvasive technique was developed to evaluate the blood perfusion rate within human placenta. The method is based on monitoring the accumulation of the isotope 113mIn in the placental intervillous space using a single detector as a measuring device. The result was expressed as an accumulation index calculated from the tracer appearance curve. The In accumulation index was significantly lower in preeclamptic patients than in the controls, but with a marked overlapping. The In index was significantly correlated with the simultaneously recorded maternal minute volume, 24-hour estrogen excretion and birthweight. No correlation was found with the placental weight or Laakso's perfusion index. Uterine contractions induced a significant decrease in the In index. The authors conclude that the In accumulation index can be used as an objective measure of the placental blood flow.

Female↗
PubMedDate not supplied

Smoking does affect fecundity.

A total of 2198 mothers were interviewed at the 20th week of pregnancy and their smoking habits before pregnancy and the time from discontinuation of contraception to the beginning of the pregnancy were registered. This information was used to investigate whether smoking affects conception delay; i.e., fecundity and a multifactorial analysis were used. The longer the conception delay, the more significant was the deleterious effect of even light smoking, the odds ratio shifting from 1.1 at 6 months to 3.2 at 18 months. The effect of smoking on fecundity seemed to be mostly dose-dependent. In mothers becoming successfully pregnant in 12 months, both maternal and paternal smoking increased the risk of conception delay (OR 1.5 and 1.3), and the effect was potentiated by increasing age (OR 2.3 and 1.6). In addition to smoking, previous recurrent spontaneous abortions were also associated with fecundity.

Alcohol Drinking↗
PubMedDate not supplied

Cigarette smoking and semen quality in men of reproductive age.

The effect of cigarette smoking on conventional semen parameters was studied in voluntary men of reproductive age (n = 190). Special attention was focused on sperm motility and its quantitative and qualitative change in vitro during the observation period. The sperm output war normal in both smokers (n = 54) and non-smokers (n = 110), but semen volume was smaller (p less than 0.03) in heavy smokers (greater than 16 cigarettes/day) than non-smokers. In sperm morphology there was no difference between study groups. The only clear difference between men with different smoking habits was in the percentual change in the sperm motility during 24 hours. At the time of first examination, the sperm motility was better (p less than 0.02) in heavy smokers than those who smoked less than 16 cigarettes per day and the motility decreased more rapidly (p less than 0.007) in heavy smokers than non-smokers. The objectively measured initial mean velocities of the whole sperm population and of the progressive spermatozoa were slightly higher in subgroup of smokers than in non-smokers. The rapid decrease in the survival spermatozoa in smokers may be uneconomical and harmful in respect of fertility.

Adult↗