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Biomedical subjects

S Sundberg

Publications and source records attributed to S Sundberg.

69 records · Page 4Linked to original sources
PubMed1982

Maximal oxygen uptake in relation to age in blind and normal boys and girls.

Maximal oxygen uptake (VO2 max) was measured in 180 children during exhaustive work on a bicycle ergometer. The material comprised 12 blind boys and 11 blind girls (8-14 years) as well as 82 normal boys and 75 normal girls (8-17 years). VO2 max increased linearly with age in all four groups. In normal girls mature values were reached at the age of 14 years. Normal boys had significantly higher values than normal girls and their VO2 max increased faster with age. No sex differences in VO2 max were found in blind children. Normal children had significantly higher values than the blind. VO2 max/kg was uninfluenced by age in three of the groups: 55, 45 and 37 ml/min/kg in normal boys, blind boys and blind girls, respectively. In normal girls VO2 max/kg decreased with age from 51 to 42 ml/min/kg. Significant sex differences were found in both normal and blind children. VO2 max/kg in blind boys was 82% of that of normal boys, while blind girls had significantly lower values than normal girls. Most of these differences were established already at the age of 8 years. It is concluded that the differences in maximal oxygen uptake between normal and blind children are to a high degree due to different levels of physical activity during early childhood.

Adolescent↗
PubMed1982

Cardiorespiratory function in competitive endurance runners aged 12-16 years compared with ordinary boys.

Thirty-four male elite endurance runners aged 12-16 years and 56 ordinary boys of the same age were studied in cross-sectional age groups. At the age of 12-14 years, there were only a few differences between the runners and the controls: the runners weighted less, were leaner and had higher VO2 max/kg body weight. The runners' good competitive performance could not be explained by a superior aerobic power at that age. In the age group of 16-year-olds, additional major differences were found: significantly higher VO2 max (4.05 1/min, 66 ml/min/kg), W170 (214 W, 3.5 W/kg), vital capacity (5.31 l), maximal expiratory volume (153 1/min), lower resting heart rate (62 beats/min) and larger heart volume (792 ml and 453 ml/m2 BSA) in the runners. In this respect our runners resembled adult endurance athletes. No differences could be observed in any age group as to height, hemoglobin concentration, blood pressure and maximal heart rate. The differences at the age of 16 years are either training effects or due to a selection of certain "endurance runner types".

Adolescent↗
PubMed1979

Impact of a mobile coronary care unit on the sudden coronary mortality in a community.

A 6-month feasibility study on a mobile coronary care unit (MCCU) was implemented in an urban community provided with a WHO Acute Ischemic Heart Disease Register. MCCU was able to reach in time less than 5% of all cases of unexpected cardiac arrest in the community. For cases of myocardial infarction and cardiac arrest transported by MCCU, a pair-matched control series was obtained from a period of 2-8 months before the beginning of the MCCU activity. No difference was found in the first 28 days' mortality rate between MCCU and control groups. The operation of MCCU did not induce any reduction of the patient delay time in the community.

Acute Disease↗
PubMed1975

Blood pressure in adult Lapps and Skolts.

Casual blood pressures were recorded in 331 Lapps and 221 Skolts over the age of 20. The systolic pressure was found to rise more with age in women than in men. In neither sex did age affect the diastolic pressure. A general tendency towards higher blood pressure in Lapps than in Skolts was noted up to the age of 50-60 years. Comparison with a Finnish population and one from the Aland Islands revealed similar systolic blood pressures in females, but definitely lower values in male Lapps and Skolts. The Lapps and Skolts did not have the clear age dependence of the diastolic blood pressure as occurs in Finns. These findings, together with other population studies, support the hypothesis that the setting of the resting blood pressure level is influenced by different kinds of stress associated with technological development and with an urbanized way of life.

Adult↗
PubMedDate not supplied

Haemodynamic interactions between the novel calcium sensitiser levosimendan and isosorbide-5-mononitrate in healthy subjects.

OBJECTIVE: The new calcium sensitiser levosimendan also possesses vasodilatory effects due to potassium-channel opening. The aim of the present study was to assess the possible haemodynamic interactions between levosimendan and isosorbide-5-mononitrate in young healthy men. METHODS: The study was crossover, placebo controlled, double blind, randomised, and it comprised of four study days with one medication--levosimendan, isosorbide-5-mononitrate, levosimendan plus isosorbide-5-mononitrate or placebo--given on each. Levosimendan was administered i.v. as an initial bolus dose of 12 microg/kg over 10 min, followed by a continuous infusion of 0.2 microg/kg/min for a total time of 2 h. Isosorbide-5-mononitrate (20 mg) was given orally as a single dose. Leg blood flow and venous capacity (venous occlusion plethysmography), cardiac output (impedance cardiography), skin blood flow (laser-Doppler flowmetry), blood pressure and heart rate were recorded at baseline, and 20 min, 1 h, 2 h, 4 h and 6 h after the start of the infusion. An orthostatic test was performed at baseline and at 2 h 15 min. Twelve healthy, male subjects were included. Their mean age was 24 years (range 20-34 years). RESULTS: Levosimendan increased leg blood flow by 32%, and no additive effect of the combination of levosimendan and isosorbide-5-mononitrate was observed. The effects of levosimendan on heart rate and blood pressure were minimal and in close conformity with previous studies. In general, there were no additive effects of the combination compared with each drug alone at rest. The only additive effect was seen in the orthostatic response. Heart rate increased by 40 beats min(-1) with the combination (95% confidence interval compared with placebo 11-24 beats min(-1)), by 30 beats min(-1) with levosimendan (2-15 beats min(-1)), by 28 beats min(-1) with isosorbide-5-mononitrate (1-15 beats min(-1)), and by 22 beats min(-1) with placebo. Furthermore, three subjects were unable to stand upright for the stipulated time with the combination, and the orthostatic test had to be discontinued prematurely. There were no changes in the conduction intervals in the electrocardiogram on any of the treatments. The combination had no influence on the occurrence of headache compared with isosorbide-5-mononitrate alone. CONCLUSION: No major additive haemodynamic effects of the combination of levosimendan and isosorbide-5-mononitrate compared with each drug alone could be observed at rest. However, during an orthostatic test, the circulatory response was significantly potentiated with the combination, and three of the subjects were unable to stand upright for the stipulated time.

Adult↗
PubMedDate not supplied

Postoperative stroke in a child with cerebral palsy heterozygous for factor V Leiden.

A 5-year-old with spastic quadraparetic cerebral palsy suffered multiple strokes after extensive orthopedic surgery. Coagulation testing was undertaken to determine whether a familial thrombophilia was present. The patient was found to be heterozygous for factor V Leiden. Factor V Leiden may be a risk factor for central nervous system events in special-needs children, particularly when common medical conditions create additional procoagulant risks.

Brain Edema↗