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Biomedical subjects

S Sukenik

Publications and source records attributed to S Sukenik.

At least 91 records · Page 5Linked to original sources
PubMed1990

[Assessment of diabetic autonomic neuropathy by heart rate monitoring].

Assessment of diabetic autonomic neuropathy in a representative sample of 91 noninsulin-dependent diabetics was performed in 3 community clinics. A difference of less than 10 beats/min in heart rate between deep inspiration and deep expiration determined by ECG recording served as the criterion for autonomic neuropathy. By this test, 86% of the patients had diabetic autonomic neuropathy, a slightly higher proportion than that reported by others using similar criteria in more selected populations. The test is very sensitive and can be used for screening.

Adult↗
PubMed1990

Sulphur bath and mud pack treatment for rheumatoid arthritis at the Dead Sea area.

Forty patients with classical or definite rheumatoid arthritis in a stage of active disease were treated for two weeks at a spa hotel. The patients were divided into four groups of 10. Group I was treated with daily mud packs, group II with daily hot sulphur baths, group III with a combination of mud packs and hot sulphur baths, and group IV served as a control group. The patients were assessed by a rheumatologist who was blinded to the treatment modalities. Statistically significant improvement for a period of up to three months was observed in the three treatment groups in most of the clinical indices. Improvement in the control group was minor in comparison and not statistically significant. No significant improvement was observed in any of the laboratory variables measured. Except for three mild cases of thermal reaction there were no side effects.

Arthritis, Rheumatoid↗
PubMed1990

HLA antigens and nailfold capillary microscopy studies in patients with insulin dependent and noninsulin dependent diabetes mellitus and limited joint mobility.

We investigated the HLA status of patients with diabetes associated with limited joint mobility and microvascular complications. An increased frequency of HLA-B8, DR3 and DR4 in patients with insulin dependent diabetes mellitus (IDDM) compared to controls and patients with noninsulin dependent diabetes mellitus (NIDDM) was confirmed. HLA antigen DQw1 was detected less frequently in patients with IDDM and was negatively associated with limited joint mobility and retinopathy. Limited joint mobility was significantly correlated with disease duration in IDDM, and was associated with neuropathy in both IDDM and NIDDM and with retinopathy in IDDM. No correlation was found between DR3, DR4 and limited joint mobility or diabetic complications. We also investigated the usefulness of nailfold capillary microscopy in a large group of patients with IDDM and NIDDM. Although capillary enlargement and avascular areas were noted in a few patients, nailfold capillary microscopy was not felt to be a useful tool in the evaluation of diabetes.

Adolescent↗
PubMed1990

[Psoriatic arthritis and human immunodeficiency virus infection].

Recent reports have suggested an association between psoriasis, psoriatic arthritis and human immunodeficiency virus infection (HIV). However, few cases of coincidental occurrence of HIV infection and psoriatic arthritis have been described. We present another patient with psoriasis who developed a sudden flare-up of this skin disease associated with onset of psoriatic arthritis, during the course of HIV infection. Psoriatic arthritis should be added to the expanding spectrum of musculoskeletal manifestations of HIV infection.

Acquired Immunodeficiency Syndrome↗
PubMed1989

[Dermatomyositis associated with normal serum muscle enzyme levels].

Cases of polymyositis or dermatomyositis in which levels of all the serum muscle enzymes are within the normal range throughout the entire clinical course are very rare. It has recently been suggested that when there is no increase in creatine kinase the prognosis in dermatomyositis is poor and there is a higher incidence of malignancy and interstitial lung disease associated with the condition. We describe a rare case of dermatomyositis without increase in serum muscle enzymes, including creatine kinase. No evidence of malignancy or interstitial lung disease was found after a followup of 18 months. In accordance with the report of a similar case, we suggest that the absence of an increase in creatine kinase in dermatomyositis is not necessarily a poor prognostic sign.

Adult↗
PubMed1989

[Recurrent avascular bone necrosis in systemic lupus].

Ischemic necrosis of the bones in systemic lupus erythematosus (SLE) usually appears when treatment with corticosteroids is initiated. The most frequent site is the hip, while the knee and shoulder are less frequently involved. A 21-year-old man was admitted because of bilateral shoulder pain 3 years after diagnosis of SLE. The skin, joints, brain, small intestine and kidneys were also involved and corticosteroid therapy was started. 1.5 years before his last admission, severe knee pain developed with limitation of range of movement but without effusion or soft tissue swelling. Bone scan confirmed the diagnosis of aseptic necrosis of the femur and tibia of both knees. He also developed bilateral shoulder pain accompanied by limitation of the range of internal and external rotation. X-ray of the shoulders demonstrated bilateral ischemic necrosis. Since synovitis is relatively rare in SLE treated with corticosteroids, aseptic necrosis of the bone should always be suspected when arthralgia develops in this condition.

Adrenal Cortex Hormones↗
PubMed1989

Palindromic rheumatism in Israel--a disease entity? A survey of 34 patients.

Over a period of 10 years 34 patients were diagnosed as suffering from palindromic rheumatism. Eighty-one percent of the patients were of North African origin. This is significantly higher (p = 0.01) than the age-adjusted origin of the general population in the region. Attacks were usually monoarthritic or oligoarthritic in nature. The joint most often involved was the knee. Prophylactic therapy with colchicine was ineffective. Gold salts brought about partial remission in three of six patients. Despite a relatively long average follow-up period of 9.3 years and the finding of a positive rheumatoid factor in 12% of the patients, not one of the patients developed rheumatoid arthritis. In 50% of the patients we detected an unexplained elevation in serum globulins and immunoglobulins. The possible association between this syndrome and Familial Mediterranean Fever is discussed.

Adolescent↗
PubMed1989

Serum monoclonal antibodies derived from patients with multiple myeloma react with mycobacterial phosphoinositides and nuclear antigens.

The sera of 46 patients with multiple myeloma were examined for the presence of anti-tuberculosis (TB) glycolipids antibodies. In positive sera samples, anti-polynucleotides, anti-histones, anti-cardiolipin, anti-Sm and anti-RNP activities were sought. Antibodies against three different mycobacterial glycolipids were detected in 10 of the 46 sera. Three (P429, P557, P5) showed high titres of antibodies against all three different TB glycolipids. Of the 10 reactive samples, two antibodies were purified (P429, P557). P557 reacted with various polynucleotides and other antigens tested (Sm, RNP, cardiolipin, histones). One immunoglobulin (P207) which showed high activity against Sm and RNP had no activity against TB glycolipids and was employed as a control. The cross-reactivity between mycobacterial glycolipids and the nuclear antigens was further established by bi-directional competition assays with P429 and P557. Our study shows a high incidence (22%) of anti-TB glycolipids antibodies in sera of patients with monoclonal gammopathies, some of which show anti-DNA and other anti-nuclear antigens activities. This is additional evidence for the mycobacterial-nuclear antigen cross-reactivity which may suggest a possible role of infection (e.g., tuberculosis) in autoimmune diseases.

Antibodies, Antinuclear↗
PubMed1989

Reflex sympathetic dystrophy syndrome following minor trauma.

The reflex sympathetic dystrophy syndrome (RSDS) is an excessive or exaggerated response of an extremity to injury, manifested by burning pain, vasomotor disturbances, delayed functional recovery and trophic changes. The most common precipitating event is trauma. Early initiation of treatment improves therapeutic success. We describe three patients with RSDS, and discuss the prevalence, diagnosis and treatment of this condition. Physicians in primary care, traumatology and occupational medicine clinics should be aware of the clinical characteristics of this infrequent complication of limb trauma in order to avoid unnecessary diagnostic procedures and delay in treatment.

Adult↗