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Biomedical subjects

S Suehiro

Publications and source records attributed to S Suehiro.

150 records · Page 9Linked to original sources
PubMedDate not supplied

Mitochondrial K(ATP) channel opener prevents ischemia-reperfusion injury in rat liver.

Ischemia-reperfusion injury is responsible for the morbidity associated with liver surgery under total vascular exclusion or after liver transplantation. Recently, it has been reported that mitochondrial K(ATP) channel openers have an effect on myocardial protection via a pharmacological preconditioning action. However, it remains unclear as to whether K(ATP) channel openers can reduce ischemia-reperfusion injury in the liver. The aim of this study was to determine the effects of the mitochondrial K(ATP) channel opener, nicorandil, on ischemia-reperfusion injury in the rat liver. Male Wistar rats were subjected to 73% ischemia for 45 minutes followed by 120 minutes of reperfusion. Nicorandil (3 mg/kg) was orally administered 60 minutes before hepatic ischemia. Nicorandil significantly decreased plasma levels of alanine aminotransferase and lactate dehydrogenase by about 50% and inhibited the remarkably increased TUNEL-positive hepatocytes after reperfusion. Some mediators associated with apoptosis were analyzed by Western blotting. Cytochrome-c and caspase-3 levels in the cytosol increased after reperfusion; nicorandil inhibited the release of cytochrome-c and activation of caspase-3. The expression of Bax and Bcl-2 was significantly increased after reperfusion, being slightly inhibited by the administration of nicorandil. These results suggest that the protective effects of nicorandil against hepatic ischemia-reperfusion injury correlate with the inhibition of mitochondrial cytochrome-c release and caspase-3 activation. These findings demonstrate that nicorandil may become a therapeutic drug for ischemia reperfusion-related liver injury.

Animals↗
PubMedDate not supplied

FK778 controls acute rejection after rat liver allotransplantation showing positive interaction with FK506.

This study including prevention and rescue experiments was performed to examine the efficacy of FK778 and its interactions with FK506. In the prevention experiment, Brown-Norway rats transplanted with a 7 Lewis livers received day-course of FK778 or a combination of FK778 and FK506 treatment. For the rescue experiment, the recipients were additionally treated with FK778 from days 7 to 13. Blood chemistry and histopathological findings were used to examine the host and the graft condition. Donor-specific IgM was measured using enzyme-linked immunosorbent assays. The serum trough level of FK778 was examined by high-performance liquid chromatography. FK778 suppressed acute rejection in a dose-dependent manner. The optimal FK778 dosage was 20 mg/kg body weight (BW) d. FK778 treatment from days 7 to 13 rescued liver grafts from ongoing rejection. The combination of FK506 (0.125 mg/kg BW/d) and FK778 (20 mg/kg BW/d) maintained better graft condition than FK778 (20 mg/kg BW/d) monotherapy. In conclusion, FK778 prevents acute rejection in and rescues transplant recipients from ongoing rejection after rat liver transplantation. The optimal monotherapy dosage of FK778 was 20 mg/kg BW/d. Combination therapy with FK506 was more beneficial than FK778 monotherapy.

Alkynes↗
PubMedDate not supplied

Focal fatty infiltration of the liver mimicking a tumor: sonographic and CT features.

Focal fatty infiltration of the liver detected by ultrasonography (US) in this asymptomatic woman had unusual features. It appeared as a sharply marginated, spherical mass lesion on CT, with soft tissue attenuation values of 30 HU unenhanced and 50 HU with enhancement. This tumor-like zone completely resolved on follow-up US and CT, underscoring the need for follow-up examinations to exclude primary or metastatic tumors. Our review of the literature failed to reveal previous reports of features such as these.

Biopsy↗
PubMedDate not supplied

Effect of phlorizin on glucose transport in the inner ear.

14C-glucose was used as a tracer to study the effect of phlorizin on glucose transport into perilymph and endolymph. The transport was found to be lowered in phlorizin-injected animals compared with that in normal controls. This inhibitory effect corresponding to a phlorizin-sensitive part of glucose transport was greater in the perilymphatic system than in the endolymphatic system. Pathways which are not affected by phlorizin, are considered to exist in both compartments of perilymph and endolymph.

Animals↗
PubMedDate not supplied

Congenital anomalies of the inner ear: introducing a new classification of labyrinthine anomalies.

In a literature review of 108 articles a special effort was made to find and classify inner ear anomalies and diseases associated with inner ear anomalies. This study showed the following. Most of the diseases associated with inner ear anomalies are also associated with anomalies in other parts of the body. Hereditary characteristics comprise the most common etiological factor among the diseases associated with inner ear anomalies. Among anomalies observed in the cochlea, the vestibule, and the semicircular canals, anomalies in the cochlea are most frequently associated with various diseases and were observed in 30 of 40 diseases. Anomalies of the vestibule were observed in 25 diseases, and those of the semicircular canals in 18 diseases. Anomalies in both the osseous and the membranous labyrinth were most frequently associated with the diseases studied, as they were observed to occur with 10 of the 43 diseases. In this paper a new classification system for labyrinthine anomalies is introduced, based on this study of the literature.

Ear, Inner↗