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Biomedical subjects

S Sudo

Publications and source records attributed to S Sudo.

At least 55 records · Page 3Linked to original sources
PubMed1989

Preliminary dose finding study for subacute toxicological study of pravastatin sodium in monkeys.

Pravastatin sodium was orally administered to cynomolgus monkeys at dosage levels of 50, 200 and 800 mg/kg/day for 7 successive days. Excretion of diarrhea and/or loose stool were observed in the more than 50 mg/kg dose group, but the changes are quite mild. Animals of the 800 mg/kg dose group showed vomiting, diarrhea and/or excretion of soft stool and reduction of cholesterol content in serum. In conclusion, it is estimated that the no effective level is less than 200 mg/kg because no abnormalities were observed except for only very slight excretions of diarrhea and/or loose stool, and that the effective dose is 800 mg/kg in which vomiting was observed.

Administration, Oral↗
PubMed1989

Subacute toxicological study in monkeys treated orally with pravastatin sodium for 5 weeks.

Pravastatin sodium was administered orally to cynomolgus monkeys at dosage levels of 50, 100, 200 and 400 mg/kg/day for 5 successive weeks. Five animals of 200 mg/kg and 400 mg/kg dose groups were sacrificed during the study period, because these animals deteriorated in general condition and/or showed remarkable changes in serum biochemical examination. Pathological examination revealed hepatic and/or renal disturbance in these animals. These changes are thought to be the cause of deterioration of general condition or changes in serum biochemical examination. All other animals were terminated at the end of the study period. In the animals of the 100 mg/kg dose group, only one animal showed hepatic and renal disorder similar in nature to the changes in the animals sacrificed during the study period. No animals in the 50 mg/kg dose group showed toxic findings in any examination.

Administration, Oral↗
PubMed1987

Immunohistochemical study of Langerhans cells in skin tumors.

The behavior of Langerhans cells in skin tumors was investigated by immunohistochemical techniques using OKT6. OKT6-positive cells were numerous in squamous cell carcinomas, seborrheic keratoses and keratoacanthomas. They were rare in basal cell carcinomas, Bowen's disease, eccrine poromas, extramammary Paget's disease and warts. In solar keratosis, the number of OKT6-positive cells was almost equal or slightly larger compared to the normal epidermis. These results indicate that the density of Langerhans cells may not correlate with the degree of malignancy but, to a certain extent, with the nature of the membrane of tumor cells occurring e.g. during keratinization.

Antigens, Surface↗
PubMed1986

[Health check on radiation workers in the nuclear energy industry using Todai Health Index].

In the nuclear energy industry, the plants are located far from urban areas and the working environments are generally separate from each other for radiation protection purposes. The health investigation on radiation workers in the nuclear energy industry was carried out using the Todai Health Index questionnaire in 1982, 1983 and 1984. As a control study non-radiation workers on the other several working fields were investigated in the same manner. The results showed that the status of radiation workers in the nuclear energy industry is similar to that of the workers in the other working fields and the THI questionnaire is useful to know health and working status of a group of workers.

Adult↗
PubMed1985

[Health check by CMI (Cornell Medical Index) on radiation workers in a nuclear energy plant].

In the nuclear energy industry, plants are located far from urban areas and the working environments are generally separate from each other for radiation protection purposes. A health check on radiation workers in the nuclear energy industry was carried out using the Cornell Medical Index questionnaire. As a control study, radiation and non-radiation workers in the other working fields were investigated in the same manner. The results showed that the health status of radiation workers in the nuclear energy industry is similar to that of the workers in other working fields.

Adult↗
PubMed1982

Effects of corticosterone on protein, RNA, DNA and tubulin contents in developing male and female rat brains.

The effects of corticosterone treatment on chemical components and tubulin content were studied in the cerebrum, cerebellum and hypothalamus from male and female rats during early life. A dual effect of corticosterone treatment was observed in the cerebellum during the course of growth. In the cerebellum from 10-day-old rats, total soluble protein. DNA, and tubulin content (mg per g wet tissue) increased in the hormone-treated male organ, but RNA, DNA, and tubulin content (mg per g wet tissue) increased in the hormone-treated female. On the other hand, the cerebellum from 20-day-old rats, RNA and tubulin content (mg per g wet tissue) and relative tubulin content (mg per g total protein) decreased in the hormone-treated male organ, but the female cerebellum exhibited a decrease in total protein and tubulin content (mg per g wet tissue), and relative tubulin content after corticosterone administration. Only a few effects of the corticosterone treatment were observed in the cerebrum and hypothalamus from both sexes. It is likely that corticosterone has marked effects on the cerebellum among the three brain-regions in early life, and the dual effect of the hormone in the cerebellum appears to be due to the different responsiveness in the developmental stages of nerve cells, at which the treatment was started.

Animals↗
PubMed1982

Effects of Rb and Cs on the electrogenic Na-pump in rabbit sinoatrial node cells.

The effects of Rb and Cs on the electrogenic Na-pump of the rabbit sinoatrial node cell were studied, using conventional microelectrode techniques. Hyperpolarizations induced by K or its substitutes were recorded from the preparations which were perfused previously with an extracellular K-free solution. The K-induced hyperpolarizations after K-depletion depended linearly on K-concentration in the range of 1.35 to 10.8 mM. When 2 mM Rb was used as an activator, a subthreshold oscillation appeared and the amplitude of the spontaneous action potentials in the Rb solution was larger than with the standard solution. As the concentration of Rb increased, the Rb-activated hyperpolarization increased, but the amplitude of the action potential decreased. In the case of Cs, the induced hyperpolarization was smaller than with K or Rb, and a transient recovery of pacemaker activity and gradual hyperpolarization preceded the true recovery in the standard solution. Since these hyperpolarization effects were not observed after the application of ouabain-containing K-free solution, the hyperpolarizations were considered to be electrogenic. A small hyperpolarization induced by activation of the external site of the Na-pump appears to be necessary for the immediate recovery of automatism from arrest at low resting potentials.

Action Potentials↗
PubMed1982

Immunofluorescence studies on C1Q in mast cells.

Evidence has been obtained of deposition of complement component C1q in mast cells, by the immunofluorscence technique, using biopsy specimens from the scalp from 5 of 7 normal subjects and 14 of 17 patients with alopecia areata and also from skin lesions of 1 of 2 patients with urticaria pigmentosa studied. The fluorescence in mast cells was of a granular pattern in most instances. No deposition of immunoglobulins (IgG, IgA, IgM, IgE) or other complement components (C3, C4, C5, C9) was demonstrable in the mast cells. The specificity of the C1q deposition in mast cells was confirmed by various tests, viz., the blocking test, prerinsing of tissue sections with bovine serum albumin-containing phosphate-buffered saline, absorption test of conjugates, C1q destruction test with urea or by heating, and the Ouchterlony method.

Adolescent↗
PubMed1982

Immunofluorescence studies on complement components in lichen amyloidosus.

Immunofluorescence studies were carried out in 7 cases of lichen amyloidosus, chiefly to detect deposition of complement components in the cutaneous lesions. Examination of skin biopsy specimens revealed deposition of Clq, C3, C9 and IgM in all the patients studied. Complement and immunoglobulin levels by assays of simultaneously obtained serum samples were found to be almost within the normal limits.

Adult↗
PubMed1981

Effects of L-triiodothyronine on tubulin content in developing male and female rat brain.

The tubulin content and biochemical components were determined in the cerebrum, cerebellum and hypothalamus from intact and T3-treated male and female rats during early life. T3-treatment between 0 and 9 days of age increased soluble protein, RNA DNA and tubulin content (mg per g tissue) in the 10-day-old male cerebellum but not in the cerebrum and hypothalamus except for soluble protein and tubulin (mg per g tissue), respectively. Intracellular tubulin content (mg per mg DNA) was increased by the T3-treatment in the 10-day-old male hypothalamus but not the other regions. When T3 was administered between 10 and 19 days, there was little effect of the treatment; increased tubulin (mg per g tissue) in the cerebrum and decreased RNA (mg per g tissue) and a ratio of tubulin to protein in the cerebellum from 20-day-old males. Less response to T3-treatment was observed in female cerebrum and hypothalamus but not in the cerebellum, compared with the male. These results suggest that the effect of T3-treatment on brain is modified by several factors such as tissue specificity, age-dependency and sexual differences. Modification by these factors might depend, at least in part, on changes in the number of T3-receptors due to the hormone treatment.

Aging↗