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S Stojanović

Publications and source records attributed to S Stojanović.

At least 19 recordsLinked to original sources
PubMed2004

Sesquiterpene lactone mix patch testing supplemented with dandelion extract in patients with allergic contact dermatitis, atopic dermatitis and non-allergic chronic inflammatory skin diseases.

We investigated the value of patch testing with dandelion (Compositae) extract in addition to sesquiterpene lactone (SL) mix in selected patients. After we detected a case of contact erythema multiforme after patch testing with dandelion and common chickweed (Caryophyllaceae), additional testing with common chickweed extract was performed. A total of 235 adults with a mean age of 52.3 years were tested. There were 66 men and 169 women: 53 consecutive patients with allergic contact dermatitis (ACD); 43 with atopic dermatitis (AD); 90 non-atopics suffering from non-allergic chronic inflammatory skin diseases; 49 healthy volunteers. All were tested with SL mix 0.1% petrolatum (pet.) and diethyl ether extracts from Taraxacum officinale (dandelion) 0.1 and 3.0% pet. and from Stellaria media (common chickweed) 0.1 and 3% pet. A total of 14 individuals (5.9%) showed allergic reaction (AR) to at least 1 of the plant allergens, 4 (28.6%) to common chickweed extract, and 11 (78.6%) to Compositae allergens. These 11 persons made the overall prevalence of 4.7%: 8 (3.4%) were SL-positive and 3 (1.3%) reacted to dandelion extract. 5 persons (45.5%) had AD, 2 had ACD, 2 had psoriasis and 2 were healthy controls. The Compositae allergy was relevant in 8 cases (72.7%). The highest frequency of SL mix sensitivity (9.3%) was among those with AD. Half the SL mix-sensitive individuals had AD. ARs to dandelion extract were obtained only among patients with eczema. A total of 9 irritant reactions (IRs) in 9 individuals (3.8%) were recorded, 8 to SL mix and 1 to common chickweed extract 3.0% pet. No IR was recorded to dandelion extract (P = 0.007). Among those with relevant Compositae allergy, 50.0% had AR to fragrance mix and balsam of Peru (Myroxylon pereirae resin) and colophonium. SLs were detected in dandelion but not in common chickweed. Our study confirmed the importance of 1 positive reaction for emerging, not fully established, Compositae allergy. In conclusion, the overall prevalence of 4.7% in our study represents a basal SL mix detection rate of 3.4% reinforced and safely supplemented by testing with the dandelion extract.

Adolescent↗
PubMed2002

[Carcinoma of the anal canal--results of radical radiotherapy].

From February 1995 to August 2001, 34 pts with squamous cell carcinoma of the anal canal (stage T2-35.3%, stage T3-44.1%, stage T4-20.6%, stage N1-29.4%) were treated prospectively by definitive radiotherapy only, delivered with megavoltage linear accelerator, combined with intracavitary brachytherapy in some patients, at the Institute for Oncology and Radiology of Serbia. Total tumor dose was range 55-75 Gy. Median follow-up time was 24.7 mounts (range 6-66 mounts). Overall survival and disease free survival at 5 years were 65.44% and 68.44%. Local control was 82.3% (28/34 pts). Eight pts had local or distant failure. Early and late complication rates were acceptable. In majority of patients the anal sphincter function was preserved.

Adult↗
PubMed2001

Efficiency and mechanism of the antioxidant action of trans-resveratrol and its analogues in the radical liposome oxidation.

trans-Resveratrol (trans-3,5,4'-trihydroxystilbene) is a nonflavonoid polyphenol reported to exert different biological activities, among them inhibition of the lipid peroxidation, scavenging of the free radicals, inhibition of the platelet aggregation, and anticancer activity as the most important. In order to enlighten the radical-scavenging mechanism of trans-resveratrol, stationary gamma-radiolytic experiments in liposomes and pulse radiolytic experiments in aqueous solutions were performed. Applying the stationary gamma-radiolysis together with the subsequent product analysis, reactions of lipid peroxyl radicals, LOO*, with trans-resveratrol and other natural antioxidants were investigated. It was found that trans-resveratrol was a better radical scavenger than vitamins E and C but similar to the flavonoids epicatechin and quercetin. The comparison of the radical-scavenging effects of trans-resveratrol and its analogues trans-4-hydroxystilbene and trans-3,5-dihydroxystilbene revealed that trans-resveratrol and trans-4-hydroxystilbene showed almost the same effect and were more efficient than trans-3,5-dihydroxystilbene. These findings indicate greater radical-scavenging activity of trans-resveratrols para-hydroxyl group than its meta-hydroxyl groups. Using the pulse radiolysis, reactions of trans-resveratrol and its analogues with trichloromethylperoxyl radicals, CCl(3)OO*, were studied. Spectral and kinetic properties of the observed transients showed great similarity between trans-resveratrol and trans-4-hydroxystilbene which seems to confirm that para-hydroxyl group of trans-resveratrol scavenges free radicals more effectively than its meta-hydroxyl groups.

2-Propanol↗
PubMed2001

[New surgical approaches in splenic diseases].

To improve the success of postoperative results, in the surgeries of the spleen diseases new procedures had been developed from hematological pretreatment to further operative and postoperative treatment of the patient. Elective splenectomy is quite a big anesthetic challenge. In the period from 1996 to 1998 in the Institute for digestive diseases 147 splenestomies had been done as a consequence of the spleen diseases. Before the operation there is no reason for compensate the platelets if their number is equal or bigger than 50 x 10(9)/l unless the patient is bleeding. If the patient has less than 50 x 10(9)/l the operation shouldn't postponed if we have previously prepared enough doses of platelets from the separator the pool, or the ordinary platelets. Now days at our clinic we operate the patients with extremly plateleptema. The operations have been very successful. The team work of surgeons, anestehsiologists and hemathologist is the most important thing.

Adult↗
PubMed1999

Exposure of Mn and FeSODs, but not Cu/ZnSOD, to NO leads to nitrosonium and nitroxyl ions generation which cause enzyme modification and inactivation: an in vitro study.

The effect of NO treatment in vitro on structural and functional alterations of Cu/Zn, Mn, and Fe type of SODs was studied. Significant difference in response to NO of Cu/ZnSOD compared to the Mn and Fe types was demonstrated. Cu/ZnSOD was shown to be stable with respect to NO: even on prolonged exposure, NO produced negligible effect on its structure and activity. In contrast, both Mn and Fe types were found to be NO-sensitive: exposure to NO led to their fast and extensive inactivation, which was accompanied by extensive structural alterations, including (in some of the samples tested) the cleavage of enzyme polypeptide chains, presumably at His residues of the enzyme metal binding sites. The generation of nitrosonium (NO+) and nitroxyl (NO-) ions in NO treated Mn and FeSODs, which produce enzyme modifications and inactivation, was demonstrated. The physiological and biomedical significance of described findings is briefly discussed.

Animals↗
PubMed1996

[Modern radiologic diagnosis of prostatic diseases].

Prostatic pathology presents one of the key elements of morbidity in adult and older males. In developed countries malignant prostatic tumors are the third most common cause of death in males older than 55 years of age. New diagnostic procedures such as transabdominal and transrectal ultrasound, computerized tomography and magnetic resonance enable direct prostatic visualization thus better and more efficient diagnostics. This study offers a review and schedule of diagnostic procedures which enable early detection and classification of prostatic diseases.

Humans↗
PubMed1995

[Pelvic inflammatory disease and the use of intrauterine contraceptive devices].

Pelvic inflammatory disease includes a group of different diseases such as: endometritis, salpingitis, oophoritis and peritonitis. The risk of pelvic inflammatory disease in intrauterine contraceptive devices--users is 7-9 times higher than in the general population, whereas the incidence of occurrence of these diseases in this certain group is 2-5%. During the period 1989-1993, 155 intrauterine contraceptive users with pelvic inflammatory disease, were treated at the Clinic, which makes 25% of all hospitalized female patients with pelvic inflammatory disease. Serious cases have been established in regard to the period 10 years ago. In order to prevent the occurrence of pelvic inflammatory disease in users of intrauterine contraceptive devices, health education is necessary to motivate regular controls and check-ups, preventive application of antiseptic vaginal tablets and detection of signs of the disease.

Female↗
PubMed1995

[Clinical and epidemiologic aspects of paraneoplastic dermatoses in hospitalized patients treated at the Clinic for Dermatologic and Venereal Diseases in Novi Sad over a 10-year period (1980-1990)].

Authors report results of a retrospective investigation on frequency of paraneoplastic dermatoses, their clinical characteristics, time of onset and course regarding 10 - year material on hospitalized patients at the Clinic for Infectious and Dermatovenerous Diseases in Novi Sad. Out of 9086 hospitalized patients in 14 patients (0.16%) paraneoplastic dermatisis was diagnosed. Out of 14 patients in 5 patients (35.71%) Herpes zoster was diagnosed; in 4 patients (28.57%) bullous dermatosis; in 2 patients (14.29%) paraneoplastic acrokeratosis; in 1 patient (7.14%) exudative multiform erythema in 1 patient (7.14%) erythema figuratum and in one more patient necrotic Herpes labialis was diagnosed. Concerning malignant neoplasms of internal organs together with paraneoplastic dermatosis in most cases (4 - 28.57%) chronic lymphocyte leucosis was found, and in remaining 10 (71.43%) carcinomas were diagnosed at different internal organs. In 7 cases (50%) malignancy proceeded paraneoplastic dermatosis, in 4 cases (28.57%) the malignancy was diagnosed at the same time as paraneoplastic dermatosis and in 3 cases (28.43%) malignancy was established after the onset of paraneoplastic dermatosis. Authors point to the fact that usual skin changes, characteristic for the dermatologic diseases mentioned, in cases when they are associated with visceral malignomas, are characterized by a more serious clinical picture, a longer course of the disease and resistance concerning usual therapy.

Aged↗
PubMed1993

[Phenotyping: personal contribution to research on increased susceptibility of individual HLA phenotype combinations in predisposition to contact allergies].

We determined the A and B locus antigenic phenotype structure by means of the lymphocytotoxic test (Terasaki) in 43 subjects with allergic contact dermatitis verified by the Patch test, as well as in 103 healthy subjects (control group). Statistical fashioning was carried out by counting all of the phenotypes in the group examined by using the 2 x 2 table the X2 test with -correction according to Yates. In a case of an existing difference in frequency, the relative risk (RR) (Svejgaard) was determined. When RR was greater relation with the disease exists with the antigen which was found to have a greater EF value (Bengtsson). A statistically significant increase of A1 antigen frequency and decrease of A28 antigen frequency, as well as the absence of B13 and BW41 antigens in the group examined can be considered as a contribution in clarifying the genetic component in contact allergy etiopathogenesis.

Adolescent↗
PubMed1993

[Ultrasonographic verification of hypertrophic pyloric stenosis].

In a two-year study on 24 newborn infants, diagnosis of hypertrophic pyloric stenosis (HPS) was intraoperatively confirmed, following preoperative ultrasonography. By means of real time sonography three parameters of the pyloric muscle were measured; the mean length was 19.6 mm, diameter 13.4 mm and the muscle thickness was 5.1 mm.

Female↗
PubMed1993

[Case report of familial generalized neurofibromatosis (von Recklinghausen disease)].

The authors made a report on a case of generalized neurofibromatosis (GN) in a patient, 21 years old, and her father, 59 years old, pointing to the family character of illness. They especially emphasized the presence of numerous family disseminated tumors of the neurofibroma type, on the skin of the torso and extremities, as well as the presence of simultaneous combination of these tumors with pigmented skin of the naevi spili (cafe au lait) type. In the reported cases no damages on other systems and organs have been found. Reports on such cases from the clinical practice may be important for education of young physicians of different medical fields.

Adult↗
PubMed1992

[Favre-Racouchot syndrome: case report].

The authors present a case of Favre-Racouchot syndrome (elastoidosis nodularis cystica et comedonica) in a male mason aged 65, associated with nodular-ulcerative type of basocellular skin neoplasm and seboroic keratosis of the irritative type. A special reference is given to nodular cystic elastoidosis (NCE) with concurrent numerous skin changes characteristic for chronic actinic skin lesions which were clinically evidenced. An objective examination of the patient revealed the presence of multiple follicular comedones, black in colour, the size of a pinhead, and of yellowish follicular papulas, 2-5 mm in size, of solid consistency, on the top of which is a formation similar to comedone. These eflorescences are densely disseminated in periorbital, zygomatic and temporal regions of the face, sparsely on the nose, forehead and preauricularly. In other regions of the face and neck other manifestations of chronic actinic skin lesions with characteristics of "citrine skin", cutis rhomboidalis nuchae and elastoma Dubreuilh are present as wall. In the right nasolabial furrow a clearly edged tumefaction, 1.2 x 0.8 cm, which belongs to the nodular-ulcerative type of basocellular skin neoplasm is seen. Seboroic keratosis of the irritative type was observed on the skin in the middle of the upper lip was histologically verified.

Aged↗
PubMed1992

[Epidemiological characteristic of basocellular skin epitheliomas treated at the Department of Dermatovenereal Diseases in Novi Sad].

The authors review some of the epidemiological characteristics of epithelioma basocellulare (EB) of the skin, showing the incidence of 2.39% of the cases treated for EB of the skin from 1984 to 1990, derived from the total of 61,384 initial examinations carried out in this period at the Department of Dermatovenereal Diseases in Novi Sad. The mean age of the patients was 64.42, the male-female ratio was slightly in favor of the females, 1:1.25. As for localization, EB of the skin were most frequently found on the face, head and neck (87.16%). Regarding occupation of the patients on the top were retired people (47.17%) and agricultural workers (33.02%) and regarding the place of living, most were found in the rural population (68.07). The mean time the treated patients came for a check-up was 1.26 year after the onset of the tumor. Relapses were found in 18 cases (1.23%). The mean time of their occurrence after the rtg therapy was 1.9 year. Familial predisposition for skin tumors was detected in 232 cases (15.79%).

Adult↗
PubMed1991

[Therapy of venous ulcers using pulsating electromagnetic fields--personal results].

The authors review the results of the treatment of venous varices by a pulsating electromagnetic field (PEMF), by the use of IVEMT-2 apparatus, treated at the Department of Dermatovenereology in Novi Sad and the Institute of Medical Rehabilitation. The treatment was carried out in 18 patients--5 men and 13 women, mean age 56 years, all with venous varices of post-thrombophlebitic origin. The number of sessions within the PEMF treatment was 10 per patient, each session lasting 15 min. The results were followed by measuring the varix surface prior to and after the treatment. The number of varices prior to the therapy was 26 and after the treatment was 20. The total surface of the varices before the treatment was 55183.90 mm2, the mean surface being 2122.46 mm2. After the treatment 6 varices epithelialized, while the total surface was 36902.51 mm2. The mean surface of the varices following the treatment was 1845.13 mm2. The varix surface reduction rate following the treatment was 33.13%. Considering the number of patients, the obtained results are preliminary and they reflect the benefits of PEMF for epithelialization of venous varices.

Adult↗
PubMed1990

[Personal experience with the use of 13-cis-retinoic acid in the therapy of severe forms of acne vulgaris].

The authors present the results of the study of the use of 13-cis-retinoic acid in the therapy of patients with a severe clinical form of acne. Twenty patients with a conglobate form of acne were included in the study. The drug was dosed in the initial phase of treatment at the dose of 0.5 mg/kg. During therapy the dose was reduced to 0.2 mg/kg depending on the clinical efficiency and appearance of unwanted effects. Therapy was conducted in the total duration of 16-20 weeks so that the patients received a mean drug dose of 0.31-0.60 mg/kg. The complete withdrawal of skin changes was registered in two patients (10%) after 12 weeks of therapy, in 15 patients (75%) after 16 weeks, and in 3 patients (15%) after 20 weeks of therapy. After the stop of drug action, the favorable effect was maintained from 2-12 months which was how long the patients were followed. The most frequently evidenced unwanted effects of therapy were dryness of the lip mucous membranes and skin. All unwanted therapy effects diminished or disappeared with drug dose decrease.

Acne Vulgaris↗
PubMed1989

[The importance of local administration of 5% 5-fluorouracil in the therapy of senile keratoses and basocellular carcinoma].

The results of the local application of 5-fluorouracil in the form of cream ("Efudix" Roche) in the therapy of senile keratoses and basocellular carcinomas were presented in this paper. A total of 205 changes of senile keratoses and 27 changes of basocellular carcinomas were treated in 90 patients. The cream was put on changes of senile keratoses without covering two times daily during a three--week period on the average up to the appearance of erosion. In cases of basaloma the cream was administered in the form of occlusive bandage with the duration of six hours each day. The treatment was undertaken until the appearance of ulceration and lasted three weeks. In all treated cases after the appearance of erosion and ulceration cream for epithelization was applied in further therapy. Out of all 232 treated changes either of senile keratosis or basaloma, successful treatment was attained in 230 (99.15%) cases and in only 2 cases of nodous basaloma successful treatment was not attained which accounted for 0.85% of treated lesions. Cosmetic results of the treatment were excellent. The appearance of relapse was not observed in any case during a three--year period.

Administration, Topical↗