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S Stella

Publications and source records attributed to S Stella.

At least 37 records · Page 2Linked to original sources
PubMed1995

Antibiotic GE37468 A: a novel inhibitor of bacterial protein synthesis. II. Structure elucidation.

GE37468 A is a novel antibiotic produced by Streptomyces sp. ATCC 55365. It has molecular mass 1309.48 and formula C59H52O12N14S5 and belongs to the thiazolyl peptide group of antibiotics. The structure was elucidated by 1H and 13C NMR and MS studies on intact molecule and its hydrolysis products. The antibiotic is a highly modified peptide containing a macrocycle and a side chain composed of a thiazole ring and two dehydroalanine units.

Anti-Bacterial Agents↗
PubMed1995

Antibiotic GE37468 A: a new inhibitor of bacterial protein synthesis. I. Isolation and characterization.

GE37468 A is a new thiazolyl peptide antibiotic obtained by fermentation of Streptomyces sp. strain ATCC 55365. It inhibits bacterial protein synthesis by acting on elongation factor Tu and is structurally and functionally related to the GE2270 class of EF-Tu inhibitors. It is active in vitro against Gram-positive bacteria and Bacteroides fragilis, and protects mice against Staphylococcus aureus infection.

Animals↗
PubMed1994

PAI-1 and factor VII activity are higher in IDDM patients with microalbuminuria.

Microalbuminuria is associated with an increased risk of cardiovascular disease (CVD) in insulin-dependent diabetes mellitus (IDDM) patients, but the pathophysiological basis of this association is not clear. To see whether or not hemostatic dysfunctions might contribute to explain this association, we measured tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), factor VII activity, plasma fibrinogen, and plasma endothelin-1 (ET-1) in 13 microalbuminuric (albumin excretion rate [AER], 20-200 micrograms/min) and in 13 comparable normoalbuminuric (< 20 micrograms/min) IDDM patients. t-PA and ET-1 were similar in the two groups, whereas PAI-1 activity (5.65 +/- 1.92 vs. 0.85 +/- 0.58 IU/ml, P < 0.05), factor VII (87.85 +/- 4.94 vs. 76.54 +/- 2.31%, P < 0.05), and plasma fibrinogen (3.38 +/- 0.21 vs. 2.65 +/- 0.13 g/l, P < 0.05) were significantly higher in microalbuminuric than in normoalbuminuric patients. Plasma fibrinogen was related to AER (r2 = 0.23, P < 0.05), whereas triglycerides and factor VII were related to PAI-1 (r2 = 0.39, P < 0.001 and r2 = 0.10, P < 0.05). These results suggest that microalbuminuria is associated with a hypercoagulative and hypofibrinolytic state. Hemostatic dysfunctions might be a pathogenetic link between microalbuminuria and CVD.

Adult↗
PubMed1993

Fibrinolytic imbalance in essential thrombocythemia: role of platelets.

Thrombotic and hemorrhagic complications are frequent in patients with essential thrombocythemia (ET), a myeloproliferative syndrome with an increased number of circulating platelets. Since platelets are a physiological reservoir for the plasminogen activator inhibitor (PAI-1) contained in plasma, we evaluated plasma and platelet tissue plasminogen activator (tPA) and PAI-1 in 20 ET patients with and without thrombotic complications and in 13 control subjects. In ET patients with thrombotic complications there was a significantly greater platelet PAI-1 functional activity than in ET patients without thrombotic complications and in the control group (p < 0.05 and p < 0.025, respectively). Moreover, platelet tPA activity was significantly low in all ET patients (p < 0.001). This fibrinolytic imbalance (increased plasminogen inhibitor and lowered activator) might be a critical cofactor in the thrombotic complications in ET patients.

Adult↗
PubMed1993

[Anomalies of coagulation and fibrinolytic activity in patients with chronic pulmonary thromboembolism].

INTRODUCTION: Haemostatic and fibrinolytic parameters were evaluated in patients with chronic pulmonary hypertension following pulmonary embolism (CPE). The diagnosis of CPE was based on lobar or segmental defects on perfusion lung scans and by pulmonary angiograms which showed complete or partial obstruction of main or segmentary lobar arteries. METHODS: Antithrombin III (AT III), protein C, protein S, and lupus anticoagulant (LA) were assayed in 8 patients with CPE; in 6 out of 8 patients plasma fibrinolytic activity was assessed both under basal conditions and after venous stasis. The control group consisted of 4 normal subjects. Protein C and protein S antigens were assayed by an electrophoretic method. Protein C and protein S biological activities were assayed by a manual clotting system. AT III was assayed by chromogenic method. Fibrinolytic total activity was studied on fibrin plates, tPA and PAI-1 activities by chromogenic method; tPA and PAI-1 antigens by ELISA technique. RESULTS: One patient out of 8 showed a protein C deficiency and 3 patients out of 8 were positive for a LA. All patients had a statistically significant reduction of plasma fibrinolytic activity (p < 0.001) and of tPA activity (p < 0.0005) after venous stasis as compared to the control group. CONCLUSIONS: Our data show that significant haemostatic abnormalities may underlie this disease. In particular, a) an impairment of fibrinolytic plasma activity and low levels of plasminogen activator may be found, and b) the undiagnosed presence of a LA may be the cause of these thrombotic events. The meaning of these results needs further assessment.

Adult↗
PubMed1992

[The role and problems of the surgical approach in adrenal incidentalomas].

The authors report a series of 5 incidentalomas: 4 nonfunctioning adrenocortical adenomas and 1 nonfunctioning pheochromocytoma. They emphasise the importance of US, CT, MRN, and scintigraphy in differential diagnosis compared to laboratory tests. In addition, they affirm that a correct oncological approach necessarily involves radical surgery and rule out the possibility of adopting a "wait and see" policy based on relative factors such as tumour size, function and the patient's age. The authors suggest using a posterior or anterior access route depending on the nature and size of the incidentaloma and recommend reserving the lateral incision for special cases.

Adenoma↗
PubMed1992

[Primary non-Hodgkin's lymphomas of the stomach].

Histological and staging classifications of gastric non-Hodgkin lymphomas are reported. On the basis of their experience and taking into account the above mentioned principles, the authors dwell upon the advantages and limits of endoscopy for the diagnosis of such neoplasms. The primary role of surgery in the management of gastric lymphomas is also confirmed.

Adult↗
PubMed1991

A high throughput assay for inhibitors of HIV-1 protease. Screening of microbial metabolites.

A novel method for discovery of HIV-1 protease inhibitors in complex biological samples has been developed. The assay is based on two specific reagents: a recombinant protein constituted by a portion of the HIV-1 Gag polyprotein comprising the p17-p24 cleavage site, fused to E. coli beta-galactosidase, and a monoclonal antibody which binds the fusion protein in the Gag region. Binding occurs only if the fusion protein has not been cleaved by the HIV-1 protease. The assay has been adapted for the screening of large numbers of samples in standard 96-well microtiter plates. Using this method about 12000 microbial fermentation broths have been tested and several HIV-1 protease inhibitory activities have been detected. One of these has been studied in detail.

Amino Acid Sequence↗
PubMed1990

[Early gastric cancer: staging and diagnostic-therapeutic trends].

The Authors in reviewing the main epidemiological and histological features of Early Gastric Cancer, dwell upon the atypical symptomatology pointing out the importance of an early diagnosis for a successful surgical treatment. Furthermore, they affirm the primary role of subtotal gastrectomy, associated with regional lymphadenectomy and omentectomy. At last, the need to extend postoperative follow-up to the main abdominal and thoracic organs for the frequency of synchronous or metachronous neoplasms is stressed.

Adenocarcinoma↗
PubMed1983

[The citizen's opinion on genetic counseling. Acceptability of the service in the province of Ferrara (Cento)].

At Cento (Ferrara), a town characterized by a moderate incidence of thalassemia, only 8.62% of men and 16.53% of women have a fair knowledge of genetic diseases and of their prevention. This lack of information was common to all categories covered by the poll. In spite of this, public was generally in favour of a genetic consultancy service. Table 1 reveals that 74.14% of men and 83.47% of women would use the informations provided by genetic consultancy for preventive purposes.

Attitude↗
PubMed1982

[The client's viewpoint on genetic counseling. Acceptability of the service in a Bolognese community (Castel San Pietro Terme)].

It has been found that the public's knowledge of genetic diseases and their prevention was extremely limited in the Commune of Castel San Pietro Terme (Bologna). This lack of information was common to all categories covered by the poll. In spite of this, the public was generally in favour of a genetic consultancy service. Overall figures reveal that 84.06% of men and 79.58% of women interviewed would use the information provided by genetic consultancy for preventive purposes.

Down Syndrome↗