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Biomedical subjects

S Spencer

Publications and source records attributed to S Spencer.

99 records · Page 6Linked to original sources
PubMedDate not supplied

Outcomes of adult cadaveric renal transplantation in ireland 1986 to 2001.

BACKGROUND: Since the introduction of renal transplantation in the Republic of Ireland in 1964, the number of transplants performed annually has increased from single figures in the 1960s to the current rate of approximately 130 renal transplants per year. Improvements in graft and patient outcomes have been associated with the introduction of the immunosuppressive agent Cyclosporin (CSA) in the mid 1980s. AIMS: The aim of this study was to examine trends in outcomes and factors that influence outcomes for adult kidney transplantation from 1986 to 2001. METHODS: All adult cadaveric kidney transplantations carried out between 1986 and 2001 were included. We separated the transplanted grafts and patients into four time periods; 1986-1989, 1990-1993, 1994-1997, 1998-2001. Graft and patient survival outcomes were compared for the different periods. RESULTS: The one-year kidney graft survival rate increased from 82% during 1986-1989 to 86% during 1998-2001. Patient survival over the four time periods studied has remained stable at approximately 95% at one year. CONCLUSION: We report a significant improvement in kidney graft outcomes over the past 16 years. Patient survival has remained relatively stable during this period.

Adult↗
PubMedDate not supplied

Alzheimer's disease: in vivo detection of differential vulnerability of brain regions.

The severe cognitive impairment during the later stages of Alzheimer's disease is usually preceded by a selective disturbance in the ability to remember new experiences. With quantitative, high-resolution magnetic resonance imaging techniques, it is now possible to determine, in vivo, differences in the pattern of anatomical changes that might reflect behavioral symptomatology during different stages of the disease. In the present investigation, magnetic resonance imaging examinations were carried out in aged controls and in clinically diagnosed Alzheimer's disease patients who were divided into three groups based upon dementia severity. Atrophy of the hippocampal formation, a region important for memory function, was observed even in Alzheimer's disease patients with the mildest dementia. With more prominent dementia, atrophy extended to the parahippocampal gyrus and the temporal neocortex.

Adult↗
PubMedDate not supplied

Characterizations of advocacy by practicing nurses.

This qualitative descriptive study explored nurses' views of patient advocacy. Seventeen hospital and community nurses were interviewed to determine whether and how they exercise the advocacy role and what they believe promotes or impedes the practice of advocacy. Findings suggested that the advocacy role was not uppermost in the minds of many of the respondents. However, when queried, the nurse-patient relationship emerged as a salient feature of advocacy; teaching, informing, and supporting were frequent activities of nurses in what they described as advocacy; and interpersonal relatedness, rather than issues of accountability and ethics, were central to the advocacy process. Work environment barriers--such as time, economics, acuity, and power hierarchies--combined with factors, such as lack of autonomy and fatigue, to create reasons not to advocate. Physicians contributed to nurses' willingness or unwillingness to advocate depending on their availability, openness to patients and nurses, and their personal demeanor. A conceptual model of client advocacy emerged from the data to guide further explorations of advocacy. The advocacy role is a critical, perhaps unique dimension of professional nursing that is changing rapidly and may be diverging from the usual role prescribed in the professional literature and taught in baccalaureate nursing curricula.

Humans↗
PubMedDate not supplied

Interictal spikes and hippocampal somatostatin levels in temporal lobe epilepsy.

We investigated the relationship between somatostatin-like immunoreactivity (SSLI) and interictal spikes (IIS) in human temporal lobe epileptic tissue. IIS counted manually from depth electrode recordings obtained preoperatively were expressed as spike frequency in anterior, middle, and posterior portions of hippocampus. SSLI was determined by radioimmunoassay (RIA). An inverse relationship between SSLI in the entorhinal cortex (EC) and IIS frequency in hippocampus was present (r = -0.55, p = 0.06). No correlation between IIS and SSLI in CA4, CA3, CA1, or the dentate was evident. This finding suggests a role of the EC in generation, regulation, or expression of interictal paroxysmal electrical activity in temporal lobe epilepsy (TLE), for which somatostatin may be a marker.

Electroencephalography↗
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Spasm in MS.

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Education, Nursing, Continuing↗
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Diabetes update.

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Diabetes Mellitus, Type 2↗