Search PubMed⌕ Search

Biomedical subjects

S Sood

Publications and source records attributed to S Sood.

At least 109 records · Page 6Linked to original sources
PubMed1995

Post-traumatic brain abscess: experience of 36 patients.

Thirty-six patients with post-traumatic brain abscess were managed over 18 years. They constituted 9.3% of all brain abscesses encountered during the same period. The head injury was associated with an external compound fracture in 20, internal compounding in three and was closed in 13 patients. The mean interval between the time of injury to presentation with an abscess was 113 days. This did not differ significantly in patients with closed and compound head injury, and amongst patients who had wound sepsis and with clean wounds after the injury. The occurrence of focal neurological deficit was more frequent in patients with a closed injury (p < 0.05). Twenty patients underwent primary excision of the abscess with recurrence of the abscess in one patient. Of the 14 patients in whom the abscess was initially aspirated, eight patients required a subsequent excision. Excision was required in 18 patients (94.7%) with external compound injury, five (50%) of those with closed injury and in all patients with internally compound injuries. Two patients had 'coned' and died before they could be operated upon. The operative mortality in the absence of signs of herniation preoperatively was 12.5% in patient with compound injury and none among patients with closed head injury.

Brain Abscess↗
PubMed1995

Effect of vitamin D deficiency on electrocardiogram of rats.

Electrocardiograms (ECGs) were studied in rats fed vitamin D deficient diet for 12 weeks. The results indicated significant shortening of QT interval of ECG. Other intervals were normal when compared with age matched control rats. Heart/body weight ratio was significantly increased in vitamin D deficient group, which is an index of hypertrophy, with increased collagen fiber in the histology of the myocardium, inspite of normal serum calcium level. The results suggested a direct role of vitamin D in the regulation of cardiac functions.

Animals↗
PubMed1994

Intracerebral hemorrhage after evacuation of a subdural hematoma in an infant.

Intracerebral hematomas following evacuation of a subdural hematoma have been described in adults resulting from sudden decompression during the drainage of the hematoma. In infants an open fontanelle and patent sutures are expected to offer protection against sudden decompression. We report the occurrence of intracerebral hematoma in an infant following evacuation of a subdural hematoma. The multiplicity and centripetal spread of the postoperative hematomas suggested that they had resulted from sudden decompression.

Brain↗
PubMed1994

Endosulphan poisoning presenting as status epilepticus.

A case of generalised seizures following ingestion of 20 cc of endosulphan (Endocel), an organochloride insecticide is presented. The patient, a young male of 25 years made a complete recovery. The mode of action of endosulphan is due to involvement of cholinergic neuronal system and the management is on the line of status epilepticus.

Adult↗
PubMed1993

Useful components of the shunt tap test for evaluation of shunt malfunction.

Results of shunt tap were studied in 224 clinically or radiologically suspected instances of shunt malfunction. In 130 retrospectively studied patients the results of the tap had reported the opening pressure and ease of aspiration. In 94 prospectively studied instances the shunt tap parameters described were (i) the opening pressure, (ii) the drip interval, i.e., the interval between the drops of cerebrospinal fluid when the open end of the butterfly used for tapping was placed 5 cm below the level of the valve, and (iii) the closing pressure. The efficacy of the aspiration procedure for proximal malfunction was 40.3%, compared with the efficacy of drip interval which was 95.1%. For distal malfunction, the efficacy of measurement of opening pressure was 54.3% whereas that of closing pressure was 60.6%. An in vitro model of a functioning shunt showed that the opening and the closing pressures were related to the flow rate and the level of the distal catheter tip with respect to the valve, whereas the drip interval was linearly related to the flow through the proximal catheter and was independent of the distal catheter position. The opening pressure, closing pressure, and the drip interval recorded at surgery were not significantly different from the values obtained by shunt tap. The results suggested that shunt tap accurately provides information otherwise obtained at surgery and the drip interval is most useful for evaluating a proximal malfunction. The subjective impression of the distal flow may be more helpful in diagnosing distal malfunction rather than the absolute level of opening or closing pressures.

Cerebrospinal Fluid Pressure↗
PubMed1993

Hemifacial spasm: early postoperative normalization of blink reflex latency.

Electrophysiological improvement in the blink reflex latency after neurovascular decompression of the facial nerve in patients with hemifacial spasm is believed to be related to remyelination and occurs 2-8 months after surgery. We report a patient with hemifacial spasms for 3 years, in whom the increased blink reflex latency returned to normal within a week after surgery. This suggests that compression without demyelination may be responsible for increased blink reflex latency in some of the patients with hemifacial spasms.

Adult↗
PubMed1993

Circanual variation of sperm count and motility in men.

Seasonal variation in rhythmicity of spermatogenesis might be due to external temperature fluctuation which could partially be responsible for decreased sperm counts in summer. Other factor like exposure to light might contribute for the reduction in sperm counts. These facts should be taken into account before diagnosing male fertility.

Adult↗
PubMed1992

Cardiopulmonary resuscitation in very low birthweight infants.

Of 191 patients with birthweight less than 1500 gm admitted to our neonatal intensive care unit in a 2-year period, 41 underwent cardiopulmonary resuscitation (CPR). Eleven of 41 very low birthweight (VLBW) (27%) survived to be discharged. None of the infants who received CPR after 72 hours of life survived. Also, all infants who underwent CPR, both in the delivery room and neonatal intensive care unit (NICU), died. The most significant factor distinguishing survivors from nonsurvivors was the demonstration of vasopressor unresponsive hypotension 20 hours prior to CPR in the latter group. This study confirmed the very poor survival rate after CPR in VLBW infants. We conclude that performance of CPR in patients with vasopressor unresponsive hypotension or previous delivery room resuscitation should be considered a rescue or experimental treatment and parents should be given the option of no resuscitation. Future research efforts should be directed to better the understanding and treatment of cardiovascular dysfunction prior to cardiac arrest.

Cardiopulmonary Resuscitation↗
PubMed1992

CT evaluation of orbital osseous hemangioma.

Two patients with osseous hemangioma of the orbit, and with typical features on plain radiography and computed tomography, are reported. The typical features of osseous hemangioma of the orbit on computerised tomography (CT) are: expansile bony lesion limited by a thin sclerotic rim, bony trabeculae radiating from the centre to the periphery of the lesion, and absence of an associated extra-tumoral soft tissue mass. To the best of our knowledge this is the first report of osseous hemangioma of the orbit evaluated by CT.

Hemangioma↗
PubMed1992

Somatosensory and brainstem auditory evoked potential in congenital craniovertebral anomaly; effect of surgical management.

Clinical features and evoked potential recordings were analysed in 32 patients with congenital atlantoaxial dislocation before and after surgery. Seven patients (group 1) had atlantoaxial dislocation, while 22 patients had associated basilar invagination (group 2). In both groups, pyramidal tract signs, posterior column signs, wasting of the upper limbs, and abnormality of somatosensory evoked potentials (SSEP) were similar. Conversely, lower cranial nerve involvement and abnormal brainstem auditory evoked potentials (BAEP) were significantly more in patients with basilar invagination (p less than 0.05). All seven patients in group 1 and 17 patients in group 2 were operated upon. Clinical and electrophysiological deterioration were significant in patients with basilar invagination (group 2), following posterior fixation compared with group 1. Among the patients in group 2, who clinically deteriorated following posterior fixation, seven had transoral excision of odontoid and six of them improved both clinically and electrophysiologically. Two patients in group 2 had odontoid excision before posterior fixation, and in both the evoked potentials improved postoperatively. In group 1 the patient's BAEP remained unaffected following posterior fixation, however, in group 2, eight patients over 53% showed improvement in brainstem function following posterior fixation. This study shows the value of evoked potentials in congenital atlantoaxial dislocation, and rationalizes the surgical procedure in these patients. In patients with basilar invagination, odontoid excision is the preferred first stage procedure.

Atlanto-Axial Joint↗
PubMed1992

Effect of vitamin D deficiency on testicular function in the rat.

To study the effect of vitamin D deficiency on testicular function, 30-day-old male rats were put on a vitamin-D-deficient diet. At 120 days of age, the testicular function of these animals was compared with that of rats of the same age group fed, ad libitum, a diet containing vitamin D and rats fed on a restricted amount of diet with vitamin D. In vitamin-D-deficient rats, there was a significant reduction in the total body weight, testicular and epididymal sperm count and testicular glutamyl transpeptidase activity (an index of Sertoli cell function) as compared to control group rats, but there was no difference in the testicular lactate dehydrogenase activity (an index of germ cell function). Histological examination of the testis in vitamin-D-deficient rats revealed a significant reduction in the Leydig cell count along with degenerative changes in the germinal epithelium. Histological examination of the tibia revealed excess of osteoid in vitamin-D-deficient rats only. On the other hand, in undernourished rats given a normal amount of vitamin D, the only significant change was a reduction in total body weight. These results suggest that vitamin D deficiency retards spermatogenesis by interfering with the function of Sertoli and Leydig cells.

Animals↗
PubMed1991

Bedside diagnostic blood testing. Its accuracy, rapidity, and utility in blood conservation.

OBJECTIVE: --Bedside diagnostic testing utilizing microchemistry instruments potentially offers physicians the opportunity to evaluate urgent blood test results rapidly and reliably using only drops (250 microL) of whole blood. The use of microchemistry technology may also represent an essential component of a blood conservation program in acutely ill patients. We tested the hypothesis that a microchemistry instrument would have important advantages in the intensive care unit, including rapid turnaround time, decreased iatrogenic blood loss, and the provision of accurate analyte results. DESIGN: --One-year prospective, random-sample comparative study. SETTING: --A tertiary, acute care, 1000-bed university teaching hospital and a 450-bed university-affiliated community hospital. PATIENTS: --Blood samples from 850 patients were analyzed. RESULTS: --There were strong correlations (for pH, R2 = .97; PCO2, R2 = .97; PO2, R2 = .99; sodium, R2 = .83; potassium, R2 = .94; chloride, R2 = .90; glucose, R2 = .98; and hematocrit, R2 = .92) when paired samples were analyzed simultaneously in the laboratory comparing the microchemistry instrument and currently accepted clinical laboratory instruments. There were significant correlations (for pH, R2 = .91; PCO2, R2 = .94; PO2, R2 = .97; sodium, R2 = .91; potassium, R2 = .86; chloride, R2 = .91; ionized calcium, R2 = .82; glucose, R2 = .96; and hematocrit, R2 = .75) but increased variability occurred in some analyte results when samples were first analyzed in the intensive care unit (using the microchemistry instrument) and then transported to the laboratory in the routine fashion for "stat" determinations. CONCLUSIONS: --The multichannel microchemistry instrument provided accurate analyte determinations when compared with accepted clinical laboratory instruments. Significant savings of time and blood were also realized by the use of a microchemistry instrument in the intensive care unit. Bedside microchemistry may provide clinically important advantages in emergency departments, operating rooms, and neonatal, pediatric, coronary, adult medical and surgical, trauma, and burn intensive care units.

Blood Chemical Analysis↗
PubMed1991

Effect of CSF shunt on brainstem auditory evoked potential in hydrocephalus secondary to brain tumour.

BAEPs were prospectively studied in thirty patients with hydrocephalus prior to and within 48 hours of CSF diversion. They comprised patients with (1) cerebellar tumours (2) brainstem tumours (3) third ventricular tumours. Preshunt BAEPs were abnormal in 80% patients with cerebellar tumour, 70% patients with third ventricular tumour and in all patients with brainstem tumour. Postshunt BAEPs improved in 70% patients with brainstem tumour and in 40% patients with third ventricular tumours. In both the groups I-III and III-V interpeak latency improved. In group 1, (cerebellar tumours) none of the patients showed improvement in the BAEP after shunt. In 7 patients of this group CCT deteriorated after the shunt. The deterioration was at the III-V interlatency in 5 patients. One patient had deteriorated at both I-III and III-V levels and another had prolongation of the I-III interlatency after shunting. In 6 patients the wave V amplitude reduced by more than 50% after shunting.

Adolescent↗
PubMed1991

Effect of some electrolytes on in vitro rumen microbial protein synthesis in buffaloes.

In vitro studies were carried out to examine the effect of MnCl2, MgCl2, CoCl2 and CaCl2 on protein synthesis by rumen microorganisms obtained from fistulated buffalo calves (Bubalus bubalis). The concentration of the electrolytes in stained rumen fluid (SRF) ranged from 1 to 20, 1 to 20, 0.25 to 5 and 1 to 20 mM, respectively. MnCl2 (15 mM), MgCl2 (10 mM), CoCl2 (2.5 mM) and CaCl2 (20 mM) increased the protein content in the incubation mixture (IM) by 501, 230.8, 537.6 and 84% and the per cent incorporation of 35S from (NH4)2 35SO4 into microbial protein by 125.6, 108.5, 113.4 and 40.3, respectively, over the control values, when the incubation lasted 8 h. The NH3-N content in IM decreased by 8, 14, 43 and 16% when 10 mM MnCl2, 20 mM MgCl2, 1 mM CoCl2 and 1 mM CaCl2, respectively, was added and the incubation lasted 6 h. The reasons for increased protein biosynthesis by rumen microorganisms in the presence of the above electrolytes are discussed.

Animals↗