Cyanoacrylate as an adhesive for other medicaments: a study with triamcinalone on the healing of experimental oral ulcers.
This study was undertaken to determine whether cyanoacrylate can be used to adhere other medicaments to oral ulcers in the hope of promoting healing. Triamcinalone was chosen since it is used presently in pastes in the oral cavity. Sixty rats were dived into three equal groups. In each animal under anesthesia with ether, bilateral equivalent ulcers, 2 mm in depth and diameter, were made with the tip of a rongeur on the midlateral aspect of the tongue. The right side served as a control. The left side was experimental and received the following: group I--isobutyl-2-cyanoacrylate only; group II--powdered triamcinalone acetonide; group III--triamcinalone covered with cyanoacrylate. All materials were reapplied every 24 hours for 4 days. Two animals from each group (6) were sacrificed at 1, 4, and 8 hours and 1, 2, 3, 5, 14, and 21 days. The results indicate that a powdered medicament can be held in place on oral ulcers for at least 24 hours. The ulcers with cyanoacrylate revealed less edema and cellular response for up to 24 hours. Healing of the ulcers was neither promoted nor delayed in any group.