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S Sone

Publications and source records attributed to S Sone.

514 records · Page 29Linked to original sources
PubMedDate not supplied

Computed tomography reveals atypical localization of benign mediastinal tumors.

Computed tomographic appearances of 147 surgically proven mediastinal tumors (113 benign and 34 malignant lesions) were evaluated paying special attention to their localization or extension. Ten of the 113 benign lesions (9%) showed atypical or unique localization or extension, and were divided into three groups. In the first group, two lymphangiomas and one bronchogenic cyst spread over both the precardiovascular and the retrocardiovascular compartments, mimicking a malignant lesion. In the second group, the single cases of thymic hypertrophy, thymic cyst, schwannoma, and pericardial cyst were located atypically in the retrocardiovascular compartment. In the last group, two esophageal leiomyomas and one esophageal duplication showed upward and downward longitudinal extension beyond the azygos arch and the aortic arch.

Adult↗
PubMedDate not supplied

CT of parotid tumors.

Computed tomographic (CT) appearances of 18 surgically proven parotid tumors were studied. Digital radiography (GE, ScoutView) was performed to select the desired gantry angulations and then plain CT and CT combined with sialography were performed. Plain CT clearly showed parotid tumors in nine of the patients. CT combined with sialography was more helpful than plain CT for delineating the tumors in the other patients who had either tumors in high-density parotid glands for tumors low density. CT allows more accurate evaluation of tumor location and extent in the parotid gland than any other method and helps distinguish malignant from benign lesions. The normal CT appearances of the parotid region are necessary for precise interpretation of CT images in this region.

Adenoma↗
PubMedDate not supplied

MR evaluation of laryngohypopharyngeal cancer: value of gadopentetate dimeglumine enhancement.

PURPOSE: To investigate the value of gadopentetate dimeglumine-enhanced MR imaging in determining the extent of laryngohypopharyngeal cancer. METHODS: Unenhanced and contrast-enhanced T1-weighted, proton-density-weighted, and T2-weighted images from 24 patients with laryngohypopharyngeal cancer were reviewed and compared with the pathologic findings of resected specimens. In 18 patients, ex vivo MR images of the resected specimens were also compared with pathologic findings. RESULTS: Laryngohypopharyngeal cancer showed intermediate intensity on T1-weighted and proton-density-weighted images, high intensity on T2-weighted images, and moderate enhancement on T1-weighted enhanced images. Cartilage-invaded tumor enhanced moderately, whereas unossified cartilage in contact with tumors but without tumor invasion showed no enhancement. Laryngohypopharyngeal mucosa enhanced intensely; endolaryngeal muscles enhanced less. CONCLUSIONS: Enhanced MR images were more useful in assessing the extent of tumors and the presence of laryngeal cartilage invasion than were proton-density-weighted and T2-weighted images.

Aged↗
PubMedDate not supplied

Digital tomosynthesis imaging of the lung.

We report our preliminary results of pulmonary imaging by digital tomosynthesis, and describe some advantages of these digitally processed longitudinal tomographic images. Digital tomosynthesis of the lung was performed in 60 subjects, including 56 patients with a localized lesion or diffuse disseminated lesions, with a fluororadiographic TV unit with linear tomographic capability, in conjunction with an image processing unit. Dual energy subtraction digital tomosynthesis was also available in our system. Multiple longitudinal tomographs of the lung, which were reconstructed from a single set of tomographic image data, facilitated easy evaluation of the morphology of pulmonary abnormalities together with related broncho-vascular structures located in the same longitudinal plane as the lesion, and were immune from any problem caused by inconsistent depth of respiration. The image quality of the reconstructed tomographs was greatly improved by digital image processing to reduce tomographic blur and enhance image clarity. Dual energy subtraction digital tomosynthesis was effective in clearly showing the size, configuration, and distribution of calcification in the lesion. Digital tomosynthesis provided useful information in making the roentgenologic diagnosis of pulmonary lesions.

Adult↗
PubMedDate not supplied

A case of pleomorphic adenoma of the lung with multiple distant metastases--observations on its oncogene and tumor suppressor gene expression.

Pleomorphic adenoma of the lung is a rare neoplasm. Here we describe the first report on oncogenes and tumor suppressor genes in metastasizing pleomorphic adenoma of the lung. A 48-year-old Japanese woman presented with metastasizing pleomorphic adenoma in which both the primary lung tumor and metastatic lesions were composed of benign pleomorphic structures. The mechanism of the metastatic potential was examined by analyzing known oncogenes and tumor suppressor genes by DNA blot analysis and immunohistochemistry. No rearrangements amplifications or overexpressions of oncogenes, bcl-2, c-erbB-2, c-myc, L-myc, N-myc, Ha-ras and Ki-ras were found. In addition, immunohistochemical studies showed no aberrance in expressions of the tumor suppressor gene products, RB, p16 and p53 in the tumor. Some unknown mechanism(s) seems to be responsible for the aggressiveness of this metastasizing pleomorphic adenoma. This mechanism must be elucidated by studies on further case of this rare tumor.

Adenoma, Pleomorphic↗
PubMedDate not supplied

Successful treatment of metastatic cardiac lymphoma with complete A-V block.

Although involvement of the heart is not a rare manifestation of malignant lymphoma, most cases are diagnosed by postmortem examination. In the present article, we describe a man with metastatic cardiac lymphoma with complete A-V block successfully treated by resection of the heart tumor and sequential combination chemotherapy with cyclophosphamide, doxorubicin, vincristine and predonisolone and radiation therapy. Combination modality resulted in complete disappearance of signs of heart failure and A-V block. Our experience indicated that early diagnosis and combination modality can obtain long survival in case of metastatic cardiac lymphoma.

Aged↗
PubMedDate not supplied

A case with small cell carcinoma of the esophagus: measurement of tumor markers, including pro-gastrin-releasing peptide.

Small cell carcinoma of the esophagus is a rare clinical entity and the accumulation of information is necessary to clarify its clinical behavior. We report a 69-year-old Japanese man with this rare disease with systemic metastases, including liver, bone and lymphnodes. The patient was treated with systemic chemotherapy consisting of 300 mg/m2 of carboplatin on day 1, and 80 mg/m2 of etoposide on days 1, 2 and 3. Although transient relief of subjective symptoms was obtained, the disease showed systemic progress, and the patient died on day 25 of chemotherapy. During the clinical course of the disease, serum pro-gastrin-releasing peptide (proGRP) decreased upon systemic chemotherapy from elevated level (54.6 pg/ml) to normal range (19.2 pg/ml). Further study is warranted to examine whether measurement of serum proGRP may yield valuable information on the diagnosis and monitoring activities of esophageal small cell carcinoma.

Aged↗
PubMedDate not supplied

Normal pulmonary geometric changes due to respiration: evaluation with inspiratory and expiratory spiral CT.

RATIONALE AND OBJECTIVES: To investigate the pattern of physiological pulmonary geometric changes in the longitudinal direction due to respiration. MATERIALS AND METHODS: Spiral CT scans of the lung were obtained in 20 normal subjects at maximal inspiration and expiration, each with a table feed time of 10 mm/sec, collimation of 10 mm, and continuous sections of 5 mm in thickness. Utilizing the pulmonary vessels or bronchi as the reference points and comparing the points of these structures shown on the CT images taken at both respiratory phases, the distance of excursion in the longitudinal direction during respiration was examined. Excursion of pulmonary structures was examined from the upper edge of the manubrium to the top of the diaphragm in three lung zones in the coronal direction. RESULTS: A significant linear correlation between the distance from the upper edge of the manubrium to the structure and the distance of its excursion was found for all three lung zones (r = 0.84, p < 0.01 for the anterior zone; r = 0.89, p < 0.01 for the middle zone; r = 0.91, p < 0.01 for the posterior zone). The mean value of displacement in posterior zone was significantly greater (p < 0.01) than that in the middle zone, which was significantly greater (p < 0.01) than that in the anterior zone at each level. CONCLUSION: We have described the normal longitudinal displacement patterns of the pulmonary structures due to respiration. These findings may be applied to the diagnosis of pulmonary diseases.

Female↗
PubMedDate not supplied

Primary malignant lymphoma of the duodenum: report of a case.

We present a case of long-term survival in primary malignant lymphoma of the duodenum treated with a curative surgical resection and post-operative chemotherapy. A 72 year-old man was admitted to our hospital complaining of epigastric discomfort. Endoscopy revealed an ulcerative tumor in the duodenal bulb. The tumor was diagnosed histologically as malignant lymphoma by endoscopic biopsy. A distal gastrectomy and duodenal bulb resection were performed with lymph nodes dissection. The tumor was histologically classified as B-cell phenotype, large cell, immunoblastic lymphoma of high grade, according to the Working Formulation. The patient received CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy after the operation, and he has no sign of recurrence during a follow-up period of 6 years.

Aged↗