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Biomedical subjects

S Smith

Publications and source records attributed to S Smith.

At least 1,207 records · Page 67Linked to original sources
PubMedDate not supplied

The evolution of a distance education initiative into a major telehealth project.

After a five-year collaboration in distance learning, the University of Texas Medical Branch in Galveston School of Nursing and the Lamar University Department of Nursing in Beaumont, Texas, opened discussions during the mid-1990s about working together to establish a cutting-edge telehealth clinic. Other participants in this dialogue were the UTMB Division of Pediatric Special Services (DPSS) and the East Texas Area Health Education Center (ETAHEC). DPSS hoped to provide telehealth services for children who had to commute routinely to receive comprehensive health care. ETAHEC, which specializes in building community-academic partnerships to improve the health of populations in its service region, had already worked with members of the team, providing support for the distance education collaboration between UTMB and LU. Several meetings between representatives from the two universities and ETAHEC resulted in the decision by LU to establish an infrastructure for distance learning that could also support telehealth activities. UTMB, which offered family nurse practitioner education at LU through the earlier distance learning initiative, had extensive experience in both distance education and telehealth. It provided the expertise to ensure that the two types of technology could be provided on the LU campus. Eventually, a third university came on board, and the program expanded to provide services in six public schools. A single telehealth clinic, in operation for two years with over 112 client visits, has grown into a major telehealth initiative linking an academic health science center, universities, and school districts in Texas.

Child Health Services↗
PubMedDate not supplied

Expression of apoptosis, cell proliferation, and drug resistance genes in pediatric Wilms' tumors.

The expression of genes associated with apoptosis, cell proliferation and drug resistance in tumor cells was investigated in two pediatric Wilms' tumor patients (MCH-WT-1 and MCH-WT-3) for their association with cell cycle, daunorubicin accumulation and clinical data. DNA content, cell cycle and drug accumulation were analyzed immediately after surgery by flow cytometry and mRNA expression by reverse transcriptase-polymerase chain reaction (RT-PCR) assay. Primary cell cultures were established from tumor specimens and tumor cells in both cases showed epithelial morphology. Although cell proliferation markers (Ki67 and PCNA) were expressed in both cases, MCH-WT-3 showed higher levels of mRNA expression, which corresponded, with metastatic behavior of the tumor in the patient. While p53 and p21 mRNAs were expressed at low levels in MCH-WT1, MCH-WT-3 showed high levels of p21 mRNA only. The increased expression of cyclin kinase inhibitor (p21) in MCH-WT-3 compared to MCH-WT-1 correlated with a higher percentage of G0/G1 cell population in the tumor specimen. Despite the expression of multidrug resistance markers (MDR1 and LRP) in MCH-WT-1, flow cytometric analysis showed tumor cell populations with very low and high daunorubicin accumulation and with the absence of any effect for verapamil and dipyridamole on daunorubicin accumulation of tumor cells.

ATP Binding Cassette Transporter, Subfamily B, Mem↗
PubMedDate not supplied

Effects of speech babble on transient evoked otoacoustic emissions in normal-hearing adults.

The results of transient evoked otoacoustic emissions (TEOAEs) have been found to be adversely affected by noise. However, there are few investigations into the specific effect of background noise on TEOAEs. The purpose of the present study was to determine the effects of increasing levels of speech babble and the recording method on TEOAEs using the ILO88 Otodynamics instrumentation. Subjects were 30 normal-hearing adults (15 males and 15 females), aged between 18 and 32 years. TEOAE recordings were obtained from both ears of each subject under five different levels of speech babble delivered via a loudspeaker in sound field using both the default and Quickscreen methods of data collection. The results indicated that both the whole-wave reproducibility (WWR) and mean signal-to-noise ratio (MSNR), averaged across frequencies from about 2 to 4 kHz, decreased with increasing speech babble levels. The results also showed that the Quickscreen mode was less susceptible to noise than the default mode. The pass percentage, using either WWR > or = 50 percent or an MSNR > or = 3 dB as a pass criterion, also decreased with increasing speech babble levels. Furthermore, the findings indicated that the use of the WWR pass criterion resulted in a high failure rate under high levels of speech babble. In contrast, the MSNR pass criterion was robust to speech babble levels of up to 70 dBA in the Quickscreen mode and 65 dBA in the default setting. The clinical implications of these findings, as applied to non-sound-treated environments, are discussed.

Adolescent↗
PubMedDate not supplied

1,4,7,10-tetrakis(2,2'-bipyridyl-5-ylmethyl-bis(2,2'-bipyridine) ruthenium(II))-1,4,7,10-tetraazacyclododecane, a macrocyclic sensor for positively charged species.

The luminescent behavior of the cyclen-based macrocycle L1 was investigated to establish its sensing ability for protons and transition metal ions. It acts as a good pH sensor in the neutral region. Its interaction with Cu (II) and Ni (II) is accompanied by quenching. The rate data for the interaction with Cu (II) were measured at pH 7.43.

Chemistry Techniques, Analytical↗
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Tiresome healing.

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Fatigue↗
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Going Dutch.

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Female↗