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Biomedical subjects

S Smith

Publications and source records attributed to S Smith.

At least 1,009 records · Page 56Linked to original sources
PubMed1978

Primary pleural melanoma. A first reported case and literature reivew.

Although metastatic pulmonary and pleural melanoma has previously been noted, primary pleural melanoma has not been reported. In addition, an extracutaneous response to Adriamycin chemotherapy for melanoma is documented. The patient demonstrated a continued objective response and remained in remission for 10 months. His death was not related to the tumor, and at autopsy there was no gross or microscopic evidence of other organ involvement or origin. Previously reported unusual primary sites associated with this tumor are reviewed, and the established criteria for determination of a primary site in the lung are reiterated. Possibilities of prior unrecognized presence of a primary site are discussed. After having reviewed pertinent literature regarding this intriguing case, we believe that all necessary criteria for proof of a first report have been met.

Humans↗
PubMed1977

Effects of solid foods on growth of bottle-fed infants in first three months of life.

We studied 821 infants who were bottle-fed from birth to determine whether non-milk solids begun within the first 3 monts of life affect early growth. The infants were seen seven to 10 days and three months after birth. They were divided into three groups-those who had started solids before 6 weeks of age (657 infants); those who had started solids between the ages of 6 weeks and 3 months (124 infants); and those given cow's milk formulae alone during the first three months (40 infants). The infants were weighed and measured seven to 10 days after birth and at three months. Mean weekly rates of weight and length gain over the 3 months were calculated and did not differ significantly between the three groups. As no record was made of quantities of food taken we cannot explain the failure of solid foods to affect growth. Studies of how young infants utilise these foods are needed.

Bottle Feeding↗
PubMed1977

Antiinflammatory activity: evaluation of a new screening procedure.

Acetaminophen, ascorbic acid, aspirin, dexamethasone, indomethacin, and phenylbutazone were tested to evaluate a new antiinflammatory screen. The basic methodology of Rassaert (1) was employed with slight modifications. The technique employs a 50-mm length of cotton twine instead of a cotton pellet. The data confirm the ability of this technique to rapidly screen activity of a variety of chemicals having antiinflammatory activity. It appears that statistically significant reductions in granuloma weight range between 10% and 50%, depending on the test compound and dose employed. This technique demonstrates activity for compounds such as aspirin and acetaminophen only at extremely high doses. However, more potent agents are detectable at more reasonable dose levels. Ascorbic acid, which has been shown to have activity in other models, was inactive in this assay. Dexamethasone was the most active agent, followed by indomethacin and phenylbutazone. Duplicate assays of selected agents showed a satisfactory degree of reproducibility.

Animals↗
PubMed1977

A nurse rehabilitator's impact on patients with myocardial infarction.

A nurse rehabilitator, supplementing routine physician/nursing coronary care unit (CCU) care, was found to be effective in increasing the return to work rate (p less than .05) and decreasing smoking (p less than .05) in a randomized trial of 102 patients with acute myocardial infarction (MI). These outcomes were thought to be due to the nurse rehabilitator's efforts in increasing patient knowledge of heart disease (p less than .01) and individual counseling.

Adult↗
PubMed1977

Studies of ambulance patients with ischemic heart disease. 1. The outcome of pre-hospital life-threatening arrhythmias in patients receiving electrocardiographic telemetry and therapeutic interventions.

Patient delay in seeking medical assistance for acute ischemic heart disease and the incidence of potentially life-threatening arrhythmias en route to the hospital were examined in a 22-month community trial of ambulance telemetry. Of 7,654 patients transported, 179 who had electrocardiograms (ECGS) transmitted were found to have had acute MIs or acute myocardial ischemic events. Fifty per cent of these patients summoned an ambulance within 30 minutes and 72 per cent within two hours after the onset of acute symptoms. Fifty-eight patients had potentially life-threatening arrhythmias. Interventions with drugs and/or defibrillation was required in 22 patients with or without cardiopulmonary resuscitation (CPR); intervention with CPR alone was required in six patients. Twelve of these 28 patients survived through hospital admission and six were alive at three months. The relatively low outcome/input ratio of this experience necessitates re-evaluation of the epidemiological characteristics and patient selection criteria in populations considered for telemetry.

Aged↗
PubMed1977

Characteristics of binding between reagent-strip indicators and urinary proteins.

We describe the binding characteristics of two indicator dyes that are widely used in commercial "dip-stick" indicators for protein in urine. Binding was studied by both gel filtration chromatography and by spectrophotometric titrations. The results demonstrate that the well-known lack of sensitivity of these strips to proteins other than albumin relates to the number and affinity of binding sites on these proteins as compared to albumin. The data suggest that these test strips can screen more effectively for albuminuria than for other proteinurias.

Chromatography, Gel↗
PubMed1977

Recognition of random shapes followed at varying delays by attended or unattended shapes, digits, and line grids.

Three experiments evaluated the effect of poststimulus distractor characteristics in altering recognition of random shapes. Experiment 1 demonstrated that when 150 msec or 300 msec were allowed for processing the initial shape stimulus, recognition was lowered only when it was followed by an attended shape or digit distractor. Unattended shapes, digits, and line grids and attended line grids left recognition essentially perfect. Attended shapes lowered recognition more than attended digits. Experiment 2 found that attended shapes, digits, and line grids all masked random shapes when presented immediately upon offset of a random shape displayed for 50 msec. As processing time increased, digit distractors became less effective than shape distractors, while line grids lost all effect. The shape distractors lowered recognition up to 1,200 msec. Experiment 3 showed that the larger recognition loss produced by the shape distractor than by the digit distractor could not be attributed to differences in response procedure. It was suggested that memory for random shapes moves from brief visual storage to a limited capacity visual short-term memory. Attended shape distractors may eliminate the stimulus shape from visual short-term memory thus preventing long-term storage.

Attention↗
PubMed1977

Hepatic veno-occlusive disease due to pyrrolizidine (Senecio) poisoning in Arizona.

An infant with documented hepatic veno-occlusive disease due to ingestion of pyrrolizidine alkaloids is presented. The alkaloids were ingested in the form of an herbal tea commonly used as a folk remedy among the Mexican-American population. Among these people, this herb is known as gordolobo yerba. The patient presented with acute hepatocellular disease and portal hypertension which progressed over 2 months to extensive hepatic fibrosis. Other potential causes of hepatic venous occlusion were absent.

Chemical and Drug Induced Liver Injury↗