Search PubMed⌕ Search

Biomedical subjects

S Slogoff

Publications and source records attributed to S Slogoff.

47 records · Page 3Linked to original sources
PubMed1978

Preoperative propranolol therapy and aortocoronary bypass operation.

The relationship between long-term propranolol hydrochloride therapy and subsequent coronary bypass operation was prospectively investigated in 119 patients who were grouped three ways: propranolol therapy continued in full dosage to operation (group A), propranolol therapy discontinued or tapered 24 to 72 hours preoperatively (group B), and no preoperative propranolol therapy (control group). During preoperative hospitalization, one patient in each group A and the control group suffered an increase in anginal symptoms compared with 15 patients in group B, three of whom also had new ventricular arrhythmias. During anesthesia up to the period of cardiopulmonary bypass, 26% of group A patients showed signs of ischemia (eg, ST segment deviation or ventricular arrhythmias) as compared with 51% of the control group and 70% of group B. Hypotension and bradycardia were not more common in group A patients. No differences among groups were noted in case of emergence from bypass, need for cardiac stimulants, or mortality.

Anesthetics↗
PubMed1977

Failure of general anesthesia to potentiate propranolol activity.

To determine whether halothane and morphine, commonly used during anesthesia for cardiac operations, potentiate the beta blocking activity of propanolol, hemodynamic changes induced by five incremental doses of propranolol (10, 20, 50, 120, 200 microgram/kg) were measured during halothane, 1 per cent, in oxygen, and morphine, 4 mg/kg. Against a background of contant beta stimulation by infusion of isoproterenol, 0.1 microgram/kg/min, and vagal blockade by atropine, 3 mg, propranolol produced significant dose-related decreases in heart rate, cardiac index, stroke volume index, and left ventricular dp/dtmax and significant increases in mean aortic pressure, systemic vascular resistance, and pulmonary capillary wedge pressure. Compared with basal anesthesia with pentobarbital, 15 mg/kg, neither morphine nor halothane increased sensitivity to any measured effect of propranolol expressed as the slope of the log dose-response relationship. It is concluded that the beta blocking activity of propranolol is not potentiated by morphine and halothane anesthesia but, rather, their effects are additive.

Anesthesia, Intravenous↗
PubMedDate not supplied

Thiopental sodium by single bolus dose compared to infusion for cerebral protection during cardiopulmonary bypass.

The authors previously demonstrated that thiopental sodium infused throughout cardiopulmonary bypass (CPB) considerably reduced persistent but not transient neuropsychiatric complications after open-chamber cardiac operations. Based on the probability that emboli released at the time of aortic declamping cause most postoperative central nervous system (CNS) dysfunction, this study was designed to test whether administration of a single bolus dose of thiopental before aortic declamping provided cerebral protection equal to that of infusion throughout bypass as well as a decrease in unwanted side effects. One hundred adult patients undergoing open-chamber cardiac operations with CPB received either thiopental sodium by infusion throughout CPB (n = 52) or thiopental sodium 15 mg/kg by bolus before aortic declamping (n = 48). In 90% of the patients, thiopental sodium 15 mg/kg produced electroencephalographic (EEG) burst suppression, with more than 60 seconds between bursts. Postoperative CNS dysfunction occurred in 3 (6%) of the infusion group patients (thiopental sodium 36 +/- 10 mg/kg) and 2 (4%) of the bolus group patients (thiopental sodium 16 +/- 2 mg/kg). CNS dysfunction persisting to the tenth postoperative day occurred in only one patient, who was in the infusion group. Requirements for inotropic support on separation from CPB did not differ between groups, but average time to extubation was 2.7 hours shorter in the bolus group. The authors conclude that thiopental sodium 15 mg/kg given as a single bolus immediately before aortic declamping without the need for EEG monitoring provided the same brain protection as larger doses given by infusion titrated to burst suppression, but it did not reduce the need for inotropic support during separation from CPB.

Adult↗