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Biomedical subjects

S Skerfving

Publications and source records attributed to S Skerfving.

At least 163 records · Page 9Linked to original sources
PubMed1983

Increased frequency of lymphocyte micronuclei in workers producing reinforced polyester resin with low exposure to styrene.

A new micronucleus method based on the analysis of lymphocytes with preserved cytoplasm revealed an increased frequency of micronuclei in 38 workers employed in a plant producing styrene-modified polyester resin as compared to the frequency in 20 referents (5.9 vs 3.6%). The time-weighted average of the styrene concentration in the workroom air varied between 1 and 36 ppm (mean 13 ppm) during the last year and correlated well to low urinary levels of mandelic acid, which ranged from 9 to 316 mg/g of creatinine (mean 65 mg/g of creatinine).

Adult↗
PubMed1980

Fever induced by fluorine-containing lubricant on stainless steel tubes.

Three subjects, all smokers, handling stainless steel tubes suffered repeated attacks of general malaise, chills, and fever lasting for several hours, mainly after gas soldering. Provocations by rubbing smoking tobacco against a tube produced similar attacks, and leucocytosis, after a few hours. The presence of fluorine on the tubes and in the febrifacient tobacco was shown. A fluorocarbon polymer lubricant was suspected of causing the attacks. Heating (1000 degrees C) of the tubes eliminated the effect.

Adult↗
PubMed1979

Glomerulonephritis and exposure to organic solvents. A case-control study.

Fifty patients with biopsy-proven glomerulonephritis and 100 sex- and age-matched controls (50 patients each with non-glomerular renal disease or acute appendicitis) were asked by questionnaire and a telephone interview whether they had been exposed to organic solvents. The questioning and the evaluation of the exposure, if any, was made without knowing the diagnosis of the interviewee. Fifty per cent of the patients with glomerulonephritis reported more than slight exposure, but only 20% of the controls. Exposure to organic solvents may often play a role in the causation of glomerulonephritis.

Adolescent↗
PubMed1979

Increased frequency of chromosome aberrations in workers exposed to styrene.

Chromosomal aberrations in lymphocytes from peripheral blood were significantly more frequent in six workers from a plant manufacturing polyester resin boats (average 10.8 per 100 cells) than in six age-and sex-matched referents (5.2 per 100 cells). The contamination of the workroom air with styrene, as measured on three occasions within three years in different areas of the plant, was 50--400 mg/m3.

Adult↗
PubMed1978

Interaction between selenium and methylmercury.

The available data on the influence of selenium on the toxicity of methylmercury and of methylmercury on selenium as a nutrient and toxic agent are reviewed. Selenium as selenite has a relative protective effect on acute and subacute toxicity of methylmercury in the rat and the quail. The protective mechanism is far from clear. Of special interest is the fact that selenium-treated animals may remain unaffected, even when they have attained tissue mercury levels otherwise associated with toxic effects. Selenite causes some increase of tissue mercury levels in methylmercury-exposed animals. On the other hand, methylmercury induces a remarkable enhancement of organ concentrations of selenium in animals given selenite. The interaction between selenium and methylmercury is in many ways different from that between selenium and inorganic mercury, and also from that between selenium and other metals. Due to the considerable interspecies differences in the toxicity of methylmercury, the available data do not allow conclusions on interactions in man. Practical implications of a possible protective effect of selenium on methylmercury toxicity in humans are discussed.

Animals↗
PubMed1977

The toxicity of ethanol. A tentative risk evaluation.

A substantial knowledge has been collected on the dose-dependent toxic effects of ethanol. Whereas ethanol probably is the chemical substance exerting most toxic effects in many populations, a quantitative estimate of the upper limit of long term safe consumption from a toxicological and public health standpoint has not earlier been performed. It may be summarized that the toxic range of ethanol consumption is 35-200 g per day. Based on the available data we would propose an acceptable daily intake (ADI) for ethanol of 7 g per day. The practical consequences are discussed.

Alcohol Drinking↗
PubMed1976

Effect of a short, heavy exposure to lead dust upon blood lead level, erythrocyte delta-aminolevulinic acid dehydratase activity and urinary excretion of lead delta-aminolevulinic acid coproporphyrin. Results of a 6-month follow-up of two male subjects.

During 1 h two healthy volunteers, not earlier exposed occupationally to lead, inhaled about 100 mg of lead as a mixture of lead oxides and lead sulfate. Maximum blood lead (PbB) concentrations of about 0.5 mg/1 and minimum blood cell delta-aminolevulinic acid dehydratase activities (ALAD) (6% of the preexposure values) were observed within 38 h after exposure. PbB and ALAD returned to preexposure levels after about 300 and 150 days. A highly significant correlation between ALAD and PbB was seen even at lead levels in the range 0.1-0.2 mg/1. Delta-aminolevulinic acid, coproporphyrin and lead in the urine (ALAU, CPU, and PbU, respectively) increased. The peak levels occurred after about 15 h for ALAU and CPU and after about 24 h for PbU. There was a very good correlation between log PbU and lin PbB. ALAU increased already at PbB levels of about 0.3 mg/1.

Adult↗
PubMed1975

Blood cell gamma-aminolevulinic acid dehydratase activity in humans exposed to methylmercury.

The gamma-aminolevulinic acid dehydratase (ALA-D) activity in blood cells was studied in 15 subjects exposed to methylmercury through consumption of contaminated fish and 19 "unexposed" subjects with a similar sex and age distribution. The exposed subjects had a mean mercury level of 120 (range 15-370) ng/g blood cells while the controls had 9 (range 4-15) ng/g. Both groups had the same mean level of lead in whole blood (10+/-1 mug/100 ml). ALA-D activity decreased statistically significantly as both mercury and lead levels in the blood cells increased.

Adult↗