Biomedical subjects

S Sidney

Publications and source records attributed to S Sidney.

108 records · Page 6Linked to original sources

PubMed1989

Hip fracture in women. Incidence, in-hospital mortality, and five-year survival probabilities in members of a prepaid health plan.

The problem of hip fracture is especially serious for women, who live longer than men and who have a higher risk of the condition. Data on women older than 49 years enrolled in a prepaid medical care program were analyzed to determine the incidence of hospitalization for hip fracture, in-hospital death rate, and five-year probability of survival after hip fracture. The cumulative lifetime probability of hip fracture for women alive at age 50 years was calculated, taking into account current estimates of survival in women. As in other studies, the incidence of hip fracture increased exponentially with age. In-hospital death rate after hip fracture was low in this population (3.7%). Survival after hip fracture was correlated with age at hospitalization. About 12% of women alive at age 50 years will be hospitalized for a hip fracture at least once before they die. In this population, the incidence of hospitalization, in-hospital death rate, and lifetime probability of hip fracture were lower than in some other reports.

Actuarial Analysis↗

PubMed1988

Increased risk of cholecystectomy in users of supplemental estrogen.

We report the results of an analysis of information from a prospective cohort study of women examining the association between cholecystectomy and use of supplemental estrogens (never, current, and past use). There were 55 cases of cholecystectomy in those who had never used estrogen and 105 cases in those who had ever used estrogen. After adjustment for age, the relative risk of cholecystectomy in those who had ever used estrogen was 2.1 (95% confidence interval, 1.5-3.0). In women classified as current users based on information available in 1977, the relative risk of gallbladder disease was 2.7 (95% confidence interval, 1.8-4.0) and in past users as of this date, it was 1.6 (95% confidence interval, 1.1-2.5). When cases known to have reinitiated estrogen use after 1977 are removed from the numerator for past users and added to the numerator for current users, the relative estimate for past use decreased to 1.1 (95% confidence interval, 0.7-1.8), and the risk estimate for current use increased to 3.9 (95% confidence interval, 2.6-5.9). Although an increase in the risk of gallbladder disease in women using supplemental estrogens has been consistently observed in previous studies, the risk after cessation of use has received little attention but could be important. Our data suggest the possibility that the risk of gallbladder disease in estrogen users persists after use of the drug ceases. An increase in the risk of cholecystectomy in estrogen users that persists after drug use ends is plausible if estrogen-induced increases in the lithogenicity of bile cause gallstones to form during drug use and if these gallstones fail to dissolve even after bile lithogenicity returns to normal upon cessation of use. The effect of estrogen use on the gallbladder should be considered in weighing the net risk-benefit ratio of these drugs.

Adult↗

PubMed1988

Relationships of low density lipoprotein cholesterol with age and other factors: a cross-sectional analysis of the CARDIA study.

Presumed evolution of low density lipoprotein cholesterol (LDL-C) was studied in a baseline cross-sectional survey of 4955 18-30 year old men and women of various sociodemographic backgrounds. Specifically studied were the influences on LDL-C and the change of LDL-C with age of race, gender, education, diet, physical activity, fatness and fitness. Men increased about 20 mg/dl per 10 years of age, while women increased about 3 mg/dl. Increasing education was found to be associated with higher LDL-C in blacks, but with lower LDL-C in whites. Higher Keys diet score and body mass index were positively associated with LDL-C, while higher total caloric intake, vigorous physical activity, duration on a treadmill exercise test and usual intake of alcohol were negatively associated with LDL-C. The finding of a different relationship of LDL-C to increasing education in whites than in blacks suggests a cultural or behavioral influence in rate of increase in LDL-C.

Adolescent↗

PubMed1987

Vasectomy and the risk of prostatic cancer and benign prostatic hypertrophy.

The incidence of prostatic disease (prostatic cancer and benign prostatic hypertrophy) was studied in a cohort of 5,332 vasectomized Kaiser Permanente Health Plan members, each matched with 3 nonvasectomized comparison subjects. Relative risks of 1.0 for prostatic cancer (68 cases, 95 per cent confidence limits 0.6 and 1.7) and 1.2 for benign prostatic hypertrophy (90 cases, 95 per cent confidence limits 0.7 and 1.8) were associated with vasectomy. In this study group the risk of prostatic disease was not altered by a history of vasectomy.

Adult↗

PubMed1987

Thinness and mortality.

The relationship of thinness to mortality was examined in White adult members of the Kaiser Permanente Medical Care Program who had at least three multiphasic health checkups between 1964 and 1972, with mortality follow-up through 1980. A detailed comparison was performed of the mortality patterns of "thin" (decile 1 of Quetelet's index) and "average" weight (deciles 4 and 5) cohort members who were age 40-79 years and free of illness at the beginning of follow-up. Thin male (relative risk 1.6, 95 per cent confidence limits 1.0, 2.6) and female (R.R. 2.1, 95 per cent C.L. 1.1, 3.9) current cigarette smokers were at increased risk of mortality compared with average weight smokers. Unmeasured differences between thin and average weight smokers with respect to quantity of cigarettes smoked may have contributed to the apparent association of thinness with mortality in smokers. Thinness was not associated with increased mortality in never smokers and ex-smokers (R.R. 1.0 in men and women). As association of long-term weight loss with mortality was present in thin and average weight men and in thin women.

Adult↗

PubMed1987

Noncontraceptive estrogens and mortality: long-term follow-up of women in the Walnut Creek Study.

The effect of postmenopausal estrogen use on mortality is an important and controversial subject. To address it, we analyzed data from a ten- to 13-year mortality follow-up of the 3437 women enrolled in the Walnut Creek Contraceptive Drug Study who never used either estrogens or oral contraceptives and the 2656 women who used estrogens but not oral contraceptives. By 1983, 109 estrogen users and 110 nonusers had died. After adjusting for age, mortality in estrogen users (1.64 per 1000 woman-years) was lower than in nonusers (2.06 per 1000 woman-years) for all categories of cause of death except cancer. The lower mortality from accidents, suicide, and homicide in estrogen users has no plausible biologic explanation, and the observation suggests that life-style differences between estrogen users and nonusers account at least in part for their lower mortality. On the other hand, the observation that the relative risk of mortality due to cardiovascular disease was 0.5 in estrogen users, after adjustment for age and other cardiovascular disease risk factors, is suggestive.

Adult↗

PubMed1986

Serum cholesterol and large bowel cancer. A case-control study.

A case-control study of the relationship of serum cholesterol to large bowel cancer incidence was performed for 245 members of the Kaiser Permanente Medical Care Program in northern California. Five controls were obtained for each case, matched for age, sex, race, and time of examination. The mean serum cholesterol levels of cases were not significantly different from those of controls for all colorectal cancers, right-sided colon cancers, and left-sided colon cancers. Analysis by quartiles of serum cholesterol level suggested neither a direct nor an inverse relationship between serum cholesterol and large bowel cancer, and there was no evidence of a threshold value below which the risk of cancer increased. The study did not support the findings from other studies of an inverse relationship between serum cholesterol and large bowel cancer.

Adult↗

PubMed1986

Smoking habits among multiphasic examinees, 1979 to 1984.

In tabulating the smoking habits of 95,744 residents of the San Francisco Bay Area, as reported between July 1979 and June 1984 at multiphasic health checkups, the prevalence of current smoking was found to be higher in men than in women aged 30 years and above, but in those younger than 30 the reverse was true. In every age group, compared with male smokers, female smokers tended to smoke fewer cigarettes per day, to inhale less and to smoke cigarettes with lower tar and nicotine yield. Blacks showed the highest percentage of smokers, whites were second highest and Asians were lowest, with Asian women being substantially lower than other race-sex groups. On average, white smokers smoked more cigarettes per day and inhaled more than did black smokers, but whites were more apt to smoke low-yield cigarettes. Compared with a 1964 to 1968 study in the same setting, there has been a decrease in the prevalence of cigarette smokers but, among smokers, a higher proportion in 1979 to 1984 smoked at least 20 cigarettes per day. During the 1979 to 1984 period, there were small downward trends in the prevalence of cigarette smoking in men and white women and in the prevalence of heavy smoking among male smokers, but there was no apparent increase in the use of lower-yield cigarettes by smokers. Although this study group contained relatively fewer smokers, most of the age, sex and racial differences and long-term trends parallel what has been observed nationally.

Adolescent↗

PubMed1983

Cholesterol, cancer, and public health policy.

A review of prospective cardiovascular epidemiologic studies reveals an inverse relationship between serum cholesterol levels and cancer mortality in half the studies in which this relationship has been examined. This inverse relationship has been demonstrated only for males, and is most consistently demonstrated for large bowel cancer. However, a review of international and intergroup epidemiologic data reveals that dietary fat intake is positively correlated with mortality rates for all cancers and for large bowel cancer. Internationally, there is also a positive correlation between mortality rates for ischemic heart disease and for cancer, as well as a positive correlation between mean population values of total serum cholesterol levels and cancer mortality. The biologic plausibility of the relationship between low serum cholesterol levels and cancer, and between high dietary fat intake and cancer are examined, with particular reference to large bowel cancer. Models are proposed to provide a coherent framework in which both low serum cholesterol levels and high dietary fat intake are risk factors for carcinogenesis. It is concluded that, on the basis of present knowledge, limitation of dietary fat and cholesterol intake is a prudent public health measure for the prevention of both coronary heart disease and cancer.

Adult↗

PubMedDate not supplied

Epidemiology of low total plasma cholesterol concentration among young adults: the CARDIA study. Coronary Artery Risk Development in Young Adults.

BACKGROUND: Data on stability of plasma total cholesterol levels and its determinants among young adults are lacking. Knowledge of factors associated with low levels of plasma total cholesterol during young adulthood may help clarify the nature of associations between hypocholesterolemia and health or illness. METHODS: Tracking of plasma total cholesterol was investigated using data from the baseline (1985-1986), Year 5 (1990-1991), and Year 7 (1992-1993) examinations of the Coronary Artery Risk Development in Young Adults Study. Lifestyle (including dietary), physiological, medical, and psychological correlates of plasma total cholesterol were examined cross-sectionally at baseline using ANCOVA and multivariate logistic regression. The attributes of participants with persistently low plasma total cholesterol level after 7 years (i.e., remaining below the 10th percentile of sex- and race-specific distributions) were also examined. RESULTS: The cohort in this analysis comprised 720 black men, 922 white men, 899 black women, and 944 white women who were between the ages of 18 and 30 years at baseline. Between 44 and 52% of those with plasma total cholesterol levels below the 10th percentile remained below the same percentile 7 years later. Among black men, a difference of 1 SD in age [3.7 years; odds ratio (OR) = 0.69; 95% CI = 0.52-0.91] and a difference of 1 SD in systolic blood pressure (10.5 mm Hg; OR = 0.73; 95% CI = 0.54-0.97) were independently associated with lower odds, respectively, of being in the lowest 10th percentile of the plasma total cholesterol distribution. Also among black men, current smoking and more calories from carbohydrates were associated with nonsignificantly higher odds of low total cholesterol level. Among white men, a 1 SD older age (3.4 years; OR = 0.78; 95% CI = 0.61-1.00) and a 1 SD higher physical fitness (118 sec; OR = 1.41; 95% CI = 1.09-1.82) predicted lower and higher odds, respectively, of low plasma total cholesterol. Among black women, a 1 SD difference in albumin (0.3 g/dL; OR = 0.80; 95% CI = 0.63-1.03) was related to lower odds of low plasma total cholesterol. Among white women, the factors independently associated with low plasma total cholesterol were body mass index (OR for a difference in 4.0 kg/m2 = 0.73; 95% CI = 0.54-1.00) and gamma-glutamyl transferase (OR for an increase in 9.6 IU/L = 0.41; 95% CI = 0.18-0.93). The independent predictive factors of stably low total cholesterol levels were age and uric acid among black men (both inversely related) and age, Framingham Type A Behavior (inversely), and calories from carbohydrates (positively related) among white men. CONCLUSION: Young adults with low plasma total cholesterol level have characteristics generally associated with good cardiovascular health. However, adverse attributes such as current cigarette smoking (notably among black men) may confound future associations between low total cholesterol and disease.

Adolescent↗

PubMedDate not supplied

Occupational attainment, smoking, alcohol intake, and marijuana use: ethnic-gender differences in the CARDIA study.

OBJECTIVES: To evaluate the prospective interrelationship of smoking, alcohol intake, marijuana use, and educational and occupational attainment of Black and White young adults. METHODS: Logistic or mixed model linear regression were used to evaluate relationships between self-reported substance use, ethnicity, gender, college graduation, and four measures of occupational attainment. RESULTS: College graduation in the next 10 years was negatively associated with smoking and marijuana use, but not daily alcohol consumption in all ethnic and gender groups. In Whites, marijuana use was associated with less prestigious occupations and lower family income, while smoking was unrelated and moderate daily drinking was positively associated. In Blacks, marijuana use was generally unrelated to occupational measures, while smoking and daily alcohol consumption were negatively associated. CONCLUSIONS: Relationships between smoking, marijuana use, daily drinking, and occupational attainment were not universally negative in this age group. Substance use, particularly smoking, is associated with reduced occupational attainment in Blacks compared with Whites after considering sociodemographic factors potentially limiting educational progression and occupational attainment.

Achievement↗

PubMedDate not supplied

Evidence of discrepant data regarding trends in marijuana use and supply, 1985-1988.

Between 1985 and 1988, the estimated number of current marijuana users (i.e., use within the past 30 days) in the United States declined 36%, based on self-report data from the National Household Survey on Drug Abuse. During the same time period, estimated nondomestic production of marijuana available for consumption in the United States increased 58% and domestic production increased 119%, while there was no clear-cut trend in prices. Reports of marijuana use associated with emergency room visits more than doubled in these years. The reasons for these apparent discrepancies in the data regarding the supply and use of marijuana are unknown. The possible causes of change in these and other measures of illicit drug use are examined because they form the basis for assessment of the efficacy of the recently proposed 1989 National Drug Control Strategy.

Cannabis↗

PubMedDate not supplied

Differences in calcium metabolism between black and white men and women.

To determine whether environmental factors influence racial differences in calcium metabolism, the authors evaluated the influence of three factors (season, length of sunlight exposure, and diet) on calciotropic hormones, renal calcium excretion, and markers of bone turnover in an ambulatory population aged 25-36 years. Included were 109 black men, 114 white men, 95 black women, and 84 white women. Compared with white subjects, black subjects of both genders showed lower levels of serum 25-hydroxyvitamin D (25-OHD) and higher levels of serum 1,25-dihydroxyvitamin D [1,25(OH)(2)D]. The mean winter levels of 25-OHD were 19 to 29% lower than the summer levels in all groups. The urinary calcium excretion was 26% lower in black men than in white men and was 36% lower in black women than in white women. The parathyroid hormone levels were 29% higher in black women than in white women, but no statistically significant racial differences in parathyroid hormone levels were seen in men. Bone turnover markers (serum osteocalcin, bone-specific alkaline phosphatase, urinary pyridinoline cross-link excretion) did not show consistent racial differences. Racial and gender differences in calcium excretion did not significantly correlate with differences in lifestyle or with levels of the calciotropic hormones. Environmental factors such as diet and sunlight exposure do not appear to influence racial differences in the levels of the calciotropic hormones or renal calcium excretion.

Adult↗

PubMedDate not supplied

Association of fasting insulin with blood pressure and lipids in young adults. The CARDIA study.

The association of insulin with cardiovascular disease (CVD) may be mediated in part by the associations of insulin with CVD risk factors, particularly blood pressure and serum lipids. These associations were examined in 4576 black and white young adults in the CARDIA Study. Fasting insulin level was correlated in univariate analysis with systolic blood pressure (r = 0.16), diastolic blood pressure (r = 0.13), triglycerides (r = 0.27), total cholesterol (r = 0.10), high density lipoprotein (HDL) cholesterol (r = -0.25), and low density lipoprotein (LDL) cholesterol (r = 0.14), and with age, sex, race, glucose, body mass index, alcohol intake, cigarette use, physical activity, and treadmill duration (all p less than 0.0001). After adjustment for these covariates, insulin remained positively associated with blood pressure, triglycerides, total and LDL cholesterol, and apolipoprotein B and was negatively associated with HDL, HDL2 and HDL3 cholesterol, and apolipoprotein A-I in all four race-sex groups. Higher levels of fasting insulin are associated with unfavorable levels of CVD risk factors in young adults; these associations, though relatively small, can be expected to increase the risk of atherosclerosis. Demonstration of these relationships in a large, racially diverse, healthy population suggests that insulin may be an important intermediate risk factor for CVD in a broad segment of the U.S. population.

Adolescent↗

PubMedDate not supplied

Distribution of lipoproteins and apolipoproteins in young adults The CARDIA Study.

While there are many studies of the distribution of coronary heart disease risk factors in children, adolescents, and middle-aged adults, little information is available on this topic in young adults. The Coronary Artery Risk Development in Young Adults Study (CARDIA) examined 4858 men and women who fasted 10 or more hours, were ages 18 to 30, and were representative of black and white residents of four U.S. communities. Compared with white men, black men had higher age-adjusted mean levels of high density lipoprotein cholesterol (HDL-C) (6.7 mg/dl, p less than 0.001) and apolipoprotein A-l (apo A-l) (9.1 mg/dl, p less than 0.001) and lower concentrations of triglycerides (-19.7 mg/dl, p less than 0.001) and apolipoprotein B (apo B) (-3.3 mg/dl, p less than 0.001). Compared with white women, black women displayed higher concentrations of low density lipoprotein cholesterol (LDL-C) (5.7 mg/dl, p less than 0.001), apo A-l (2.6 mg/dl, p = 0.001), and apo B (3.0 mg/dl, p less than 0.001), but lower triglycerides (-5.8 mg/dl, p=0.001). Gender differences were more pronounced among whites: white men displayed lower mean levels of HDL-C and apo A-l (-9.2 and -7.3 mg/dl, p less than 0.001) and higher concentrations of LDL-C, triglycerides, and apo B (5.2 20.3, and 5.3 mg/dl, p less than 0.001) than white women. Attained level of education was significantly associated with a favorable lipoprotein/apolipoprotein profile, particularly among white women. These data indicate substantial variation in the distribution of lipoproteins and apolipoproteins in young adults, which may be important determinants of future coronary disease risk.

Adolescent↗

PubMedDate not supplied

Obesity and cholecystectomy among women: implications for prevention.

Almost all studies of the association of body mass with the risk of gallbladder disease have found that risk increases with obesity. Some studies report a nonlinear relationship of body mass to gallbladder disease risk, and some report that the association of excess body mass with increased risk of gallbladder disease is confined to younger women. We examined the association of body mass with the risk of cholecystectomy based on data from 14 years of follow-up of 16,638 women. The cholecystectomy rate was much greater in the highest quintile of Quetelet's body mass index than in other quintiles. The striking association of high rates of cholecystectomy with the highest quintile of Quetelet's body mass index was observed in each age group studied. The low incidence of cholecystectomy in young, thin women made the relative risk of cholecystectomy in women in the fifth quintile of body mass highest in women under 25 years of age. The observation that cholecystectomy rates are not linearly associated with obesity suggests that women in the highest quintiles of body mass could be considered a reasonable group in which strategies for prevention of gallbladder disease might be tested.

Adult↗

PubMedDate not supplied

Sexually transmitted diseases among young heterosexual urban adults.

A self-administered, confidential survey of respondents' history of selected sexually transmitted disease (STD) was conducted in 1987-88 among adults enrolled in a multicenter study of cardiovascular disease. Respondents (and response rates) included 535 white men (78 percent), 694 white women (89 percent), 262 black men (48 percent), and 472 black women (64 percent), ages 21 to 40 years at the time of the survey. Among those who were heterosexually active, 43 percent of black women, 37 percent of black men, 33 percent of white women, and 21 percent of white men reported ever having had at least one STD in the survey. A history of syphilis or gonorrhea was more commonly reported by blacks than whites; a history of genital herpes, chlamydia, or genital warts was more commonly reported by women than men. Independent risk factors for having had at least one STD in the survey included female sex; use of cocaine, amphetamines, or opiates; and lifetime number of sex partners. The number of sex partners was the most predictive risk factor. Black race was a significant marker for other, unidentified STD risk factors. The data show a high prevalence of a lifetime history of STD among young heterosexual urban U.S. adults with possible implications for the future spread of human immunodeficiency virus infection.

Adult↗

PubMedDate not supplied

Changes in sexual behavior by young urban heterosexual adults in response to the AIDS epidemic.

Young adults residing in four States were enrolled in the period 1985-88 in a multicenter study of cardiovascular disease risk factors. In 1989, 2,729 members of the group were given a self-administered questionnaire that included questions on changes in sexual behavior that subjects had made in response to the epidemic of acquired immunodeficiency syndrome (AIDS). The final sample of 1,601 young, heterosexual, urban respondents included 412 white men, 568 white women, 224 black men, and 397 black women, all ages 21 to 40 years. Overall, nearly 50 percent of the sample reported having made at least one change in their sexual behavior in response to the AIDS epidemic to decrease their risk of becoming infected by the human immunodeficiency virus. The mean number of changes was 0.8 for white men, 1.1 for white women, 1.6 for black men, and 1.5 for black women. Change was reported more frequently by black respondents than white, with no significant sex differences. The categories of respondents reporting behavior changes were more often young, with a history of recreational drug use, with more sex partners, or having had anal intercourse. The most commonly reported behavior changes were reducing the number of sex partners and being more careful in partner selection. Of the 54 percent of respondents who did not report any change in sexual behavior, about 70 percent reported unprotected sex with more than one partner in the previous year. Significant sexual behavior change in response to the AIDS epidemic remains a goal for health education efforts.

Acquired Immunodeficiency Syndrome↗