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Biomedical subjects

S Shuster

Publications and source records attributed to S Shuster.

At least 343 records · Page 19Linked to original sources

Osteoporosis, skin collagen, and androgen.

Total skin collagen was found to be decreased in untreated patients with osteoporosis, particularly women, but increased after treatment with androgens in women. Decreased body collagen may possibly be a primary defect in osteoporosis, while androgens may increase total skin collagen.

Adult↗

Vitamin B12 excretion in patients with various skin diseases.

The excretion in the urine of (58)Co after an oral dose of (58)Co vitamin B(12) given together with intrinsic factor has been found to be reduced in a number of patients with psoriasis, eczema, and other less common dermatoses. There is a correlation between the abnormality and the extent of the rash. A reduced glomerular filtration rate was found in a few of the patients in whom it was measured, and this must have been responsible, at least in part, for the reduced excretion of vitamin B(12) in these patients, but abnormal vitamin B(12) excretion also occurred in the absence of impaired renal function. Our evidence is insufficient to show whether malabsorption or increased tissue utilization of vitamin B(12) was the explanation in other cases. Certainly a number of patients had steatorrhoea, and in these it is most likely that malabsorption was the major factor. In patients without steatorrhoea a lone malabsorption of vitamin B(12) cannot be excluded. A decreased serum concentration of vitamin B(12) was found in only one of the patients.

Adult↗

Effect of pregnancy on sebum excretion.

Sebum excretion rates from forehead skin were measured serially during and after pregnancy in 10 normal women. Only minor fluctuations occurred during the middle and last trimesters of pregnancy, but there was a pronounced decrease in the postpartum period. Probably a powerful sebotrophic factor is present in pregnancy, but its nature is conjectural.

Adult↗

Increased sebum excretion in patients with breast cancer.

The rate of sebum excretion from the forehead skin of patients with early breast cancer was found to be just significantly higher than in age-matched control women. This may indicate that some breast cancer patients have an increase in circulating or tissue-bound sebotrophic hormones, or a decrease in their inhibitors.

Acne Vulgaris↗