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Biomedical subjects

S Shulman

Publications and source records attributed to S Shulman.

At least 235 records · Page 13Linked to original sources
PubMedDate not supplied

Ventilatory complications of carbon dioxide laser laryngeal surgery.

STUDY OBJECTIVE: To evaluate complications associated with ventilatory techniques accompanying endolaryngeal carbon dioxide laser surgery. DESIGN: Retrospective survey of the Society of Academic Anesthesia Chairmen. SETTING: Operating room at an urban medical center. PATIENTS: Data from 15,701 patients were analyzed. MEASUREMENTS AND MAIN RESULTS: Twenty-six percent of patients were ventilated with Venturi jet ventilation and the rest through an endotracheal tube. Reported complications were classified as ventilation related and ventilation unrelated, as well as by severity. A total of 49 complications occurred in the Venturi jet group (1.2%). Of these complications, 24 were ventilation related (0.58%) and 18 were serious or life threatening (0.43%). There were no deaths in this group. Ventilation through an endotracheal tube was associated with a lower frequency of overall complications (0.36%), ventilation-related complications (0.15%), serious or life-threatening complications (0.15%), and serious or life-threatening ventilation-related complications (0.11%) (p less than 0.001). However, there were eight airway fires in this latter group, one resulting in a fatality. CONCLUSIONS: No clear choice of ventilatory technique is supported by this survey, but teamwork and experience give the best results.

High-Frequency Jet Ventilation↗
PubMedDate not supplied

Antibodies to spermatozoa. VII humoral and cellular aspects of sperm inmunity and infertility.

The occurrence of sperm antibody in serum and cervical mucus of women from intertile couples in the serum of their male partners, as well as cellular immunity to sperm, has been studied by agglutination and immobilization techniques. For a total of about 260 couples, the tests on serum showed that 18% of the women and 8% of the men were positive by the Kibrick technique and that 15% of the women and 4% of the men were positive by the F-D technique. The women who were positive in their cervical mucus were 8% of the group by the K-agg (Kibrick agglutination) technique, 2% by the MIS-agg. (Microscale agglutination) technique, and 40% by the MIS-imm. (Microscale immobilization) tecnique. In considering all three techniques. 42% of a group of 132 women were positive. Cellular immunity to sperm, by the Migration Inhibition method, was positive in 18% and zero per cent of infertile and fertile women, respectively.

Antibody Formation↗
PubMedDate not supplied

Antibodies to spermatozoa. XII. The critical performance of the Gelatin Agglutination Test (GAT).

The Gelatin Agglutination Test for detection of sperm antibodies was critically studied and evaluated. This fundamental technique for the detection of sperm antibodies was now modified in a number of details. The new procedure, termed GAT-II, is more convenient, economical, and reliable than the older form of this procedure; the volumes used are half as much, thus using less serum and less antigen, the mixtures are prepared within each Kibrick tube, thus requiring fewer transfer steps, and the foam problem is prevented, thus making observation more accurate. Secondly, an extensive study was made of the effect of the time of incubation in this procedure, comparing 30, 60, and 120 minutes for each test mixture. It was found that only 7 of the 50 tested sera (14%) showed a positive result at 30 minutes, although all 50 were positive at 120 minutes. Various details of this sort must be carefully considered, in order to make this test fulfill its potential and have maximum reliability for clinical significance.

Agglutination Tests↗
PubMedDate not supplied

Autoimmune aspects of human infertility.

Both men and women make antibodies against human sperm. For a complete diagnostic evaluation of an infertile couple, we must test the two serum samples, plus her cervical mucus and his sperm cells. The antibody factor occurs in 9% of men and in 12-15% of women from infertile couples, and at various titers. The standard, or classical, methods for antibody detection in serum include several agglutination methods: Gelatin Agglutination Test (GAT), Tumbe-Slide Agglutination Test (TSAT), Tray Agglutination Test (TAT), and Capillary Tube Agglutination Test (CTAT), plus the immobilization (Isojima). There are also newer methods; passive hemagglutination, radiolabel-antiglobulin, ATR-release cytotoxicity, hemadsorption, indirect immunobead, and ELISA. The genital secretions must also be studied. Sperm cells are judged to be antibody-coated by use of the Mixed Anti-Globulin Reaction (MAR) test or the Immunobead Test (IBT). Cervical mucus is dissolved with bromelin and tested.

Autoantibodies↗
PubMedDate not supplied

Tissue-specific antigens and autoantigens in the early developing rabbit male repoductive accessory glands.

A comparative study was undertaken dealing with the postnatal development of rabbit male accessory glands specific macromolecules with and without autoantigenic properties. The two types of macromolecules were investigated in male accessory glands from rabbits of different ages, fron newborn up to six months old. The results obtained by passive hemagglutination, inhibition of hemagglutination and immunodiffusion tests, show that both types of macromolecules rise to a sufficient amount to be detected at approximately 3 months of age. The possible mechanisms explaining the autoantigenicity or the lack of this property in the macromolecules under study are discussed.

Aging↗