Search PubMed⌕ Search

Biomedical subjects

S Shukla

Publications and source records attributed to S Shukla.

At least 91 records · Page 5Linked to original sources
PubMed1985

Lithium-carbamazepine versus lithium-neuroleptic prophylaxis in bipolar illness.

Fourteen DSM-III diagnosed patients with lithium-resistant bipolar affective disorder treated with a combination of lithium and carbamazepine were followed in a lithium clinic for one year to study the prophylactic benefit and side effects of this drug regimen. Comparison data for the previous year on lithium and neuroleptics showed that for the 9 patients who completed the study, the lithium-carbamazepine regimen was superior to lithium-neuroleptics in decreasing the number of affective episodes and side effects. Carbamazepine blood levels appeared to be a possible contributing factor in the development of side effects.

Adult↗
PubMed1984

Lithium-carbamazepine neurotoxicity and risk factors.

Five rapid-cycling manic patients developed neurotoxic syndromes when treated with a combination of lithium and carbamazepine, although all five had therapeutic plasma levels of both drugs. The risk factors for development of neurotoxicity with this drug combination are discussed.

Adult↗
PubMed1984

Predictive value of the dexamethasone suppression test in mania.

Eighteen manic patients who had abnormal results on the dexamethasone suppression test at admission were retested before discharge, when they were clinically stable. Conversion to normal suppression predicted good outcome after discharge, whereas a persistently abnormal test predicted poor outcome.

Adult↗
PubMed1984

Lichen simplex chronicus during lithium treatment.

A patient who was taking lithium developed an intensely pruritic lesion that remitted after lithium discontinuation and recurred with readministration. The condition was successfully treated with local steroid application, which permitted continuation of lithium maintenance.

Administration, Topical↗
PubMed1984

Neurological abnormalities in patients with bipolar disorder.

A test for agraphaesthesia and the face-hand test were administered to 75 DSM-III bipolar disorder patients. Twenty-five patients (33.3%) had abnormal findings on these tests. Abnormal findings were limited to the group of 54 patients with a history of long-term neuroleptic exposure. There was a strong correlation between the duration of cumulative neuroleptic exposure and the presence of abnormalities. In the group with long-term neuroleptic exposure, family history of affective disorders was negatively correlated with the presence of abnormalities. It appears that long-term neuroleptic exposure may be a contributory causal factor in the development of abnormal neurological signs in bipolar patients. A tendency toward more left-hand errors suggesting hemispheric integration dysfunction was noted in the patients exposed to long-term neuroleptics.

Adult↗
PubMed1983

Misdiagnosis of schizophrenia in bipolar patients: a multiethnic comparison.

The records of 76 bipolar (DSM-III) patients were reviewed for a history of previous misdiagnosis of schizophrenia. Multivariate analyses identified three variables significantly associated with previous misdiagnosis--auditory hallucinations, early age at onset, and ethnicity. Ethnicity remained significantly associated with misdiagnosis of bipolar patients as schizophrenic even after all other significant variables were partialled out of the equation. It appears from these data that black and Hispanic (Puerto Rican) bipolar patients may be at a higher risk than whites for misdiagnosis as schizophrenic, particularly if they are young and experience auditory hallucinations during affective episodes.

Adult↗
PubMed1975

Identification of specific hemoglobins within individual erythrocytes.

The identification of specific antibodies for a variety of inherited hemoglobin variants presents the opportunity to develop sensitive immunochemical measurement techniques for such variants. In this study antibodies specific for human hemoglobins A1 and S were isolated from immune rabbit serum. These were labeled with either fluoroscein isothiocyanate or tetramethylrhodamine isothiocyanate. Erythrocytes suspended in agar were incubated with these labeled antibodies and hemoglobins A1, S, and F were identified within individual cells by fluorescence microscopy. This capability offers potential for more specific investigation into heterogenous distribution of specific hemoglobins within an erythroycte or bone marrow cell population and for developing a sensitive technique applicable to antenatal diagnosis of specific hemoglobinopathies.

Animals↗
PubMedDate not supplied

Influence of chelating agents on the toxicity and distribution of beryllium in rats.

The effect of two new chelating agents-Tiron (4,5-dihydroxy-1,3-benzene disulphonic acid disodium salt) and succinic acid--on the mobilization of beryllium was studied. Animals were exposed to beryllium nitrate (1 mg kg(-1) i.p.) daily for 21 days. Administration of beryllium nitrate showed a marked decrease in haemoglobin percentage, blood sugar, serum alkaline phosphatase and serum protein and a significant increase in the activity of transaminases. Tissue protein and glycogen contents and the activity of alkaline phosphatase, adenosine triphosphatase and succinic dehydrogenase showed significantly decreased values, but beryllium nitrate provoked a considerable increase in the activity of acid phosphatase and glucose-6-phosphatase in the vital and reproductive organs. Significant improvement in the haematological and biochemical parameters was observed with Tiron but no therapeutic effect was seen with succinic acid. Atomic absorption spectrophotometry (AAS) also showed a decreased level of beryllium concentration in the liver and kidney after Tiron therapy.

1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium ↗