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Biomedical subjects

S Shuangshoti

Publications and source records attributed to S Shuangshoti.

At least 37 records · Page 2Linked to original sources
PubMed1995

Solitary primary lymphoma of the cerebellopontine angle: case report.

A 27-year-old woman had a solitary primary B-cell lymphoma that involved the right cerebellopontine angle. The tumor invaded the ipsilateral acoustic nerve and produced profound sensory neural hearing loss. Surgical resection was promptly followed by radiotherapy and a concluding brief chemotherapy treatment. The patient survived 34 months after the initial onset of the disease or 22 months after the combined treatments. Only six lymphomas affecting the cerebellopontine angle, three primary and three secondary, have been recorded. The combination of surgical treatment and radiotherapy appeared to offer encouraging results for primary lymphomas. The differential diagnosis of lymphoma of the cerebellopontine angle includes common acoustic neurilemoma, meningioma, epidermoid tumor, and other rare neoplasms involving this region that required pathological verification to distinguish them.

Adult↗
PubMed1995

Fatal hemorrhage from additional primary esophageal squamous cell carcinoma in a patient previously having primary bronchogenic adenocarcinoma.

A unique occurrence is presented of additional primary epidermoid carcinoma of the esophagus with fatal bleeding into the upper digestive tract after 3 years of diagnosis of primary bronchogenic adenocarcinoma of an 81-year-old Thai man. The primary bronchogenic adenocarcinoma was surgically removed and followed by radiotherapy and chemotherapy without evidence of tumor recurrence at autopsy. The epidermoid carcinoma of the lower one-third of the esophagus metastasized to the pleura of the remaining right lung. There was no complaint of dysphagia. Outward extension through the esophageal wall rather than intraluminal protrusion of the squamous cell carcinoma was thought to result in the absence of dysphagia. Although it is uncommon physicians should be aware of the occurrence of multiple neoplasms.

Adenocarcinoma↗
PubMed1995

Metaplasia of bone in lungs and bronchi: report of 2 cases.

Two cases are reported of pulmonary osseous metaplasia in elderly men aged 91 and 64 years. The first case represented disseminated metaplastic bones occurring throughout the lungs. In the second instance, small foci of metaplastic bones were localized in some bronchial walls of the upper lobe of the right lung which had old treated tuberculosis, severe fibrosis, and bronchiectasis. Both cases also had advanced pulmonary emphysema and interstitial fibrosis. It is suggested that fibrosed interstitium of the lungs and bronchial walls has turned into bony metaplasia in both patients. However, osseous metaplasia from cartilage of the bronchial walls is additionally suggested in case 2. Multiple factors probably play roles in development of bony metaplasia.

Aged↗
PubMed1995

Pathologic changes of gut in non-01 Vibrio cholerae infection.

A 14-year-old girl who had beta-thalassemia hemoglobin E disease was infected by bacteriologically proven non-01 Vibrio cholerae at 2 months postsplenectomy and died 37 hours after onset of the malady. Postmortem examination disclosed congestion, edema, and hemorrhagic foci of the mucosa of the small and large intestines. The gut mucosa was focally eroded. The gut wall was infiltrated by leucocytes, especially neutrophils, in all coats representing acute purulent and hemorrhagic enterocolitis. There was hyperplasia of lymphoid follicles in the gut mucosa and lymph nodes. It is suggested that morphologic change of the gut in non-01 Vibrio cholerae infection is more severe than in infection caused by Vibrio cholerae.

Adolescent↗
PubMed1995

Angiolipoma of suprasellar region.

An angiolipoma of the suprasellar region occurred in an 8-year-old boy. Review of 5 intracranial angiolipomas, including the current case, revealed that four were in the sellar region of one man and three women. One was in the thalamus of a man. The average age of the patients was 49 years, and average size of the tumors was 2.5 cm across. The angiolipomas associated with the sellar region often created abnormalities of the eye viz exophthalmos, decreased vision, and palsy of the oculomotor nerve. Sudden onset has ensued in a massively hemorrhagic thalamic angiolipoma. The characteristic low density with negative Hounsfield unit values in CT scan and hyperdensity in MRI of the brain suggested adipose tissue component of the angiolipoma. The angiography has depicted the angiomatous component of the latter. The combined characteristic CT scan, MRI, and angiographic features should demonstrate both vascular and adipose tissue elements of the angiolipomas before pathologic examination.

Adult↗
PubMed1994

Primary meningioma intimately related to skull: case report and review of the literature.

A report is made of a primary meningioma intimately associated with the left sphenoid ridge and temporal bone of a 41-year-old woman. The lesion produced hyperostosis of the involved bones, ipsilateral proptosis, and reduced vision for 4.5 years. The radiotherapy yielded little improvement of the exophthalmos and vision. Review of 125 reported meningiomas intimately related to the skull and presenting primarily with hyperostosis and minimal soft tissue component, including the current case, disclosed that all but one affected the cranium proper, particularly the middle ear, temporal bone, frontal bone, and parietal bone. The exceptional one was in the mandible. They tended to occur between the fifth and seventh decades of life with the peak occurrence between the fifth and sixth decades. The average age was 46 years for overall. The female-to-male ratio was 2:1. Six of 125 primary meningiomas closely associated with the skull were malignant and two of these spread to the lungs. The pulmonary metastasis was spontaneous in one case.

Adult↗
PubMed1994

Neurological manifestations in patients with malignant histiocytosis.

Of the 67 patients who were diagnosed with malignant histiocytosis at the Department of Medicine, Chulalongkorn Hospital, from January 1981 to May 1992, seven (10%) were found to have neurological manifestations. In five patients, neurologic diseases were the presenting clinical features. In the remaining two patients, the disease manifested at the time of relapse. Leptomeningeal infiltration, the most common pattern of involvement, was found in five patients. Involvement of the spinal cord was noted in three patients and cerebral parenchyma in two individuals. Two patients demonstrated peripheral neuropathy. Rapid clinical deterioration was observed in all patients after documentation of neurological diseases with a mean survival of 1.8 months. It is concluded that the frequency and pattern of neurological manifestations in patients with malignant histiocytosis are comparable to patients with non-Hodgkin's lymphoma. However, most patients with malignant histiocytosis manifested the neurological symptoms as an initial presentation while in non-Hodgkin's lymphoma, neurologic diseases usually manifest at the time of relapse or disease progression.

Adult↗
PubMed1994

Subacute necrotizing encephalopathy (Leigh's disease) in a child with particular reference to CT finding.

An example of subacute necrotizing encephalopathy, the fifth case in Thailand, was recorded. A 7-month-old boy presented clinically with vomiting, lethargy, respiratory difficulty, deteriorated consciousness, and hypotonia. The CT brain scan disclosed bilateral symmetrical radiolucencies in the basal ganglia, especially the lentiform nuclei, and thalami. Postmortem examination of these areas as well as the periaqueductal region revealed subacute necrotizing encephalopathy. It was characterized by necrosis, gliosis, and status spongiosus of the neuropil with relatively preserved neurons, and hyperplasia of small blood vessels as well as endothelium. As far as we are aware, the vast majority of abnormalities in the basal ganglia visualized by CT brain imaging often show calcific foci or high attenuation with asymmetrical distribution. Bilateral symmetrical lesions of low density are rare. We reported such an abnormality in a postmortem proven case of Leigh's disease. To recognize this finding should lead to correct antemortem diagnosis of the latter.

Basal Ganglia↗
PubMed1994

Hepatocellular adenoma in a beta-thalassemic woman having secondary iron overload.

An 18-year-old woman had a hepatocellular adenoma of 4 cm across in the right lobe of the liver which was severely hemosiderotic because of beta-thalassemia hemoglobin E disease with numerous blood transfusions. The lesion was an accidental postmortem finding. To our knowledge, this is the second example of liver-cell adenoma occurring in a patient with beta-thalassemia hemoglobin E disease with secondary iron overload. It is suggested that this is an association between hepatocellular adenoma and secondary iron overload of liver cells, a similar event to the relation observed in hepatocellular carcinoma and secondary iron overload of hepatocytes.

Adenoma, Liver Cell↗
PubMed1993

Primary papillary meningioma of the optic nerve sheath: a case of unique location and benign pathology.

I report here a case of primary papillary meningioma of the optic nerve sheath which developed in the left eye of a 54-year-old woman over a period of 20 years. A review of 123 primary papillary meningiomas, including the current instance, disclosed that they tended to occur in young patients of both sexes at an average age of 35 years, with one-fourth of them occurring in the first two decades of life, and with a female/male ratio of 3:2. These meningiomas were most frequent in the supratentorial compartment of the cranial cavity, especially on the cerebral convexity and in the parasagittal region. They were uncommon subtentorially, intraspinally, and outside the central nervous system. Most reported papillary meningiomas were claimed to be malignant, but the tumor of this particular woman was benign pathologically and clinically.

Female↗
PubMed1992

Association of primary intraspinal meningiomas and subcutaneous meningioma of the cervical region: case report and review of literature.

A report is made of a unique combination of occurrences of primary intraspinal epidural and subdural meningiomas and primary subcutaneous meningioma in the cervical region of a 15-year-old boy. The subcutaneous meningioma was detected at birth. Review of 92 recorded cases of primary dermal meningiomas revealed that they tended to occur in young patients, with an average age of 34 years for both sexes. The female-to-male ratio was 4:5. Most cutaneous meningiomas occurred in the head and neck, and the scalp was the most common site.

Adolescent↗
PubMed1991

Extramedullary subdural meningioma after trauma.

A 61-year-old man had an extramedullary subdural meningioma occurring close to the site of an old vertebral traumatic fracture and spinal cord injury. The tumor was discovered 3 years after the spinal trauma. This finding supports the existence of a causal relationship between trauma and subsequent tumor development. A review of the literature disclosed only one other case of intraspinal meningioma after the traumatic fracture of the spine with spinal cord compression.

Adult↗
PubMed1991

Massive cerebral hemorrhage from metastatic hepatocellular carcinoma.

Metastasis of hepatoma to the brain is a rare event. Even rarer is massive hemorrhage of the brain associated with metastatic hepatoma. A 57-year-old man had cirrhosis of the liver with hepatocellular carcinoma. The tumor spread to the lungs and left occipital lobe of the brain. The primary and secondary neoplasms were negative in detection of mucin, but were immunohistochemically positive to cytokeratin CAM 5.2 and KC; the finding supported the hepatocellular origin of the tumor. The metastatic tumor formed papillae in the lung and produced massive hemorrhage in the left occipital lobe. This case raised the total number of intracranial metastatic hepatic carcinomas to 34 cases. Five of 34 hepatic carcinomas metastatic to brain, including the current one, were hepatocellular carcinoma that produced massive hemorrhage.

Brain Neoplasms↗
PubMed1991

Intracranial primitive neuroectodermal tumors: experience of 7 cases with particular reference to survival.

A group of neoplasms consisting of undifferentiated neuroepithelial cells being capable of differentiating into either neuronal or glial line or both directions has been termed "Primitive Neuroectodermal Tumors (PNETs)". They have been shown to possess several similarities in clinical, radiological, and pathological features to the cerebellar medulloblastomas. The latter are well treated by surgical removal followed by radiotherapy. Therefore, we used the same regimen in treating 7 patients with intracranial PNETs and obtained an average survival of 28.7 months which is longer than those of previous reports. The analysis of our patients disclosed an optimistic view that the ideal prognosis of PNETs should be better than this.

Adolescent↗
PubMed1991

Nocardiosis: report of 2 cases with review of literature in Thailand.

Two cases of nocardiosis with underlying SLE are presented. Both were female patients aged 19 and 34 years and had been treated with steroid and endoxan for some time. Death from lesions in the respiratory tract and right kidney with growth of Nocardia asteroides at autopsy was noted in the first case. The second patient exhibited fever with dyspnea and subsequent peripheral neuromuscular dysfunction. Disseminated nocardial abscesses in multiple organs including lungs, liver, spleen, lymph nodes and subcutaneous tissue were disclosed postmortem. Moreover, intravascular dissemination of the organisms had resulted in thrombosis of several blood vessels supplying the spinal cord resulting in widespread myelomalacia. Recent infarction of a few spinal nerve roots was also observed.

Adrenal Cortex Hormones↗
PubMed1990

Pituitary adenomas: immunohistochemical: study of 90 cases.

Pituitary tumors from 90 patients were investigated using immunohistochemical study and the results were correlated with clinical records. There were 32 benign prolactinomas and two malignant counterparts, 13 growth hormone positive tumors. 10 corticotropic adenomas, and 10 gonadotropic tumors. Four tumors showed positivity for both prolactin and growth hormone, one prolactin and gonadotropin. An example of mixed, luteinizing hormone, prolactin and growth hormone was observed. Additionally, there was an adenoma composed of two compartments secreting prolactin and growth hormone. One patient had a recurrent gonadotropin adenoma after surgical removal of the original prolactinoma. Fifteen tumors were negative for all hormones and most were nonfunctioning clinically. The clinicopathologic correlations were found to be good for prolactinoma, growth hormone positive tumors and for tumors producing both prolactin and growth hormones causing a combined feature of hyperprolactinemia and acromegaly.

Adenoma↗