Biomedical subjects

S Shindo

Publications and source records attributed to S Shindo.

At least 73 records · Page 4Linked to original sources

PubMed1995

[Effects of Onpi-to (TJ-8117) on mesangial injury induced by anti Thy-1 antibody].

We investigated the effect of Onpi-to (TJ-8117) on the mesangial injury induced by anti-Thy-1 antibody. TJ-8117 (400 mg/kg/day, p.o.) given from the 1st day (from the day of injection of the anti-thymocyte serum) or 4th day (after mesangial proliferation), markedly inhibited the mesangial proliferation and hypercellularity in glomeruli. TJ-8117 prevented the increase in the number of PCNA or ED-1 positive cells in glomeruli. These results suggest that TJ-8117 is effective against glomerular disease with mesangial injury.

Animals↗

PubMed1995

[Effects of sairei-to (TJ-114) on the expression of adhesion molecule in anti-GBM nephritic rats].

In order to clarify the antinephritic mechanisms of Sairei-to (TJ-114), the effects of TJ-114 on the expression of adhesion molecules were evaluated in rats with anti-GBM nephritis. TJ-114 was administered orally once a day from the day (1st day) after anti-GBM serum injection throughout the experiment. TJ-114 inhibited crescent formation in glomeruli at the 10th day compared to control rats with anti-GBM nephritis. The ICAM-1- or VCAM-1-positive area in the glomeruli was increased in the nephritic control rats at the 10th day. In contrast, TJ-114 prevented increase in the ICAM-1- or VCAM-1-positive area in the glomeruli of nephritic rats. TJ-114 inhibited increase in the number of LFA-1- or VLA-4-positive cells in the glomeruli. One of the constituent components of TJ-114, Syo-saiko-to (TJ-9) at the dose of 750 mg/kg, also significantly inhibited increase in the ICAM-1- or VCAM-1-positive area in the glomeruli. Gorei-san (TJ-17), another component of TJ-114, inhibited increase in the ELAM-1-positive area and increase in the number of VLA-4-positive cells in the glomeruli. Prednisolone markedly inhibited increase in the positive area of those adhesion molecules and increase in the number of ligand-molecule-positive cells in the glomeruli. These results indicate that the antinephritic action of TJ-114 may be partially due to inhibition of adhesion molecule expression in the glomeruli.

Animals↗

PubMed1994

Distal arterial reconstruction using Esmarch's bandage technique to salvage upper extremity function in thoracic outlet syndrome caused by cervical ribs: a report of two cases.

We present herein the cases of two patients with thoracic outlet syndrome (TOS) who required arterial reconstruction due to gangrene of the fingers and/or hand. In both patients, the cervical ribs had produced intimal injury of the subclavian arteries, and the successive distal arterial embolism brought about severe ischemia of the affected upper extremity. To treat the TOS, the cervical ribs were resected through a supraclavicular incision. In the first patient, arterial reconstruction was performed from the subclavian artery to the radial collateral artery, a branch of the deep brachial artery, which resulted in minimizing amputation of the gangrenous hand. In the second patient, resection and direct anastomosis of the injured subclavian artery were performed, and bypass surgery from a brachial artery to an interosseous artery was carried out, preserving finger function. Reversed saphenous vein grafts were utilized and Esmarch's bandage technique was applied as a substitute for a vascular clamp in both patients. Following these case reports, we discuss the technique of performing distal bypass in the upper extremities and comment on the usefulness of Esmarch's bandage technique for preserving upper extremity function.

Adult↗

PubMed1994

Acute ischemia of the lower legs from blunt abdominal trauma: an unusual cause of atheroembolism--case report.

A 79-year-old man sustained blunt abdominal trauma in an automobile crash, resulting in intra-abdominal bleeding and acute ischemia of the lower extremities. Angiography demonstrated occlusion of the popliteal arteries bilaterally. He died of multiple organ failure despite immediate surgical intervention. Pathologic examination revealed diffuse atheroembolism of the lower legs.

Abdominal Injuries↗

PubMed1994

Blood supply of the parathyroid gland from the superior thyroid artery.

BACKGROUND: There is considerable controversy about the arterial supply to the superior parathyroid glands. Knowledge of this blood supply should be important for the surgeon performing thyroid and parathyroid operations. The purpose of this investigation was to document whether the superior parathyroid glands receive their blood supply from the superior thyroid artery. METHODS: We injected contrast material into the superior thyroid artery in 52 cadavers and determined the arterial blood supply to the parathyroid glands by using a dissecting microscope. RESULTS: The upper parathyroid gland was identified in 51 instances and the upper and lower glands in 26 instances on the side of injection. Of 92 parathyroid glands identified, 57 glands (62%) had a single artery, 26 (28%) had two, and 9 (10%) had three or more arteries. In 9 (45%) of the 20 cases specifically examined, a distinct anastomosing branch was identified between the inferior and the superior thyroid arteries, from which the upper parathyroid artery arose. CONCLUSIONS: Our study documented that the superior thyroid artery almost always supplies the upper parathyroid glands. Forty-five percent of the subjects had a distinct anastomosing branch between the superior and inferior thyroid arteries, which should be kept intact at operation to preserve the upper parathyroid function. One third of the parathyroid glands have two or more parathyroid arteries.

Arteries↗

PubMed1994

[A case of mitral stenosis with a new open pivot bileaflet valve].

The ATS Medical Open Pivot Bileaflet Valve was developed by Villafana who also developed St. Jude Medical valve and put to the first clinical use by Sadeghi on May 4, 1992. Since then, its clinical uses have been made in cases more than 1,000 in the world, centering on Europe, and its usefulness has been reported elsewhere from the aspected of its durability, anti-thrombogenic property, hemolysis, less noise and surgical operability. ATS valve was developed with 9 characteristics as (1) open pivot; (2) removed Struts; (3) wide area orifice; (4) improved stillness; (5) improved durability; (6) small loss of energy; (7) rotating orifice; (8) x-ray impermeability of orifice; (9) and easily sutured orifice. A report is made here on our experience of a clinical case of mitral stenosis by ATS valve (the first case in Japan) on September 28, 1993.

Female↗

PubMed1994

[Clinical experience with the CHAUX multi-purpose retractor].

We have performed dissection of the ITA using the CHAUX retractor in many patients. This retractor is a two-point sternal/IMA and valve retractor, with four sternal blades with individual and independent dual movement. The sliding sternal blade assemblies permit movement along the horizontal plane of the side arm. This retractor can be used for other types of cardiac surgery, as well. We obtained good results with its use for repair of distal aortic arch aneurysm. We conclude that this retractor is safe and useful for cardiac surgery.

Humans↗

PubMed1993

A case of an aortocolic fistula occurring 27 years after aorto-femoral bypass surgery, treated successfully by surgical management.

The secondary aortoenteric fistula (AEF) is a rare but grave complication of aortic reconstructive surgery. We report herein a case of an aortocolic fistula which occurred 27 years after an aortofemoral bypass. A 69-year-old man was admitted to hospital following a sudden episode of melena. He had undergone aortofemoral bypass surgery with a prosthetic graft 27 years previously for occlusive disease of the right external iliac artery. Colonofiberscopy, CT scan, and angiography were performed, and an aortocolic fistula due to an aortic anastomotic pseudoaneurysm was diagnosed. The first-stage operation, being resection of the previously implanted graft, right hemicolectomy, and aortic stump closure were carried out with concomitant axillo-right femoral bypass. A femoro-femoral crossover bypass was performed in the second stage and the patients recovery followed uneventfully. This case constitutes the longest postoperative interval for an AEF recorded in the English literature.

Aged↗

PubMed1993

Isolation of camelliaside C from "tea seed cake" and inhibitory effects of its derivatives on arachidonate 5-lipoxygenase.

A new flavonol glycoside, camelliaside C, was isolated from "tea seed cake" prepared from the defatted seeds of Camellia sinensis O. Kuntze. The structure was determined as kaempferol 3-O-beta-D-galactopyranosyl-(1-->2)-beta-D-glucopyranoside by spectroscopic methods (FAB-MS, UV, IR, 1H- and 13C-NMR) and the enzymatic transformation of camelliaside C to astragalin. Camelliaside C showed an inhibitory effect on the arachidonate 5-lipoxygenase of RBL-1 cells (IC50:1.4 x 10(-4)M) as did camelliaside A and B isolated from the same product.

Animals↗

PubMed1993

[Simultaneous operation of Cabrol's operation and sternal turnover with rectus abdominal flap].

We performed simultaneous operation of sternal turnover and Cabrol operation for a 28-year-old man, who had 3rd grade funnel chest and annuloaortic ectasia with 3rd grade aortic regurgitation. We think when both annuloaortic ectasia and funnel chest are indicated for operation, simultaneous operation is to be considered and the combination of Cabrol operation and sternal turnover with rectus abdominal flap is the best procedure.

Adult↗

PubMed1993

[Management of the severe calcified ascending aorta during coronary bypass surgery].

The best management of the calcified ascending aorta during coronary surgery has not established. Clamping of the calcified aorta causes cerebral embolism, aortic rupture and laceration as a lethal complication. Recently we had two successful cases of surgical treatment and these were treated by "Non-touch aortic technique". The femoral cannulation and ventricular fibrillation with moderate hypothermia or circulatory arrest will reduce the risk of coronary bypass surgery in the calcified aorta.

Aged↗

PubMed1992

Surgical treatment of Takayasu arteritis.

From 1959 to 1991, 93 patients underwent vascular reconstruction for Takayasu arteritis at our institution. The details of the cases were as follows: 16 were of type I (brachiocephalic ischemia), 48 type II (hypertension), 13 type III (extensive lesions with cerebral ischemia and hypertension), and 16 type IV (aneurysms). Carotid reconstruction, repair of atypical aortic coarctation, renovascular reconstruction, and aneurysm repair were performed independently or in combination. Nine operative deaths occurred, 8 cases of which were operated before 1970. The most serious of the delayed complications was suture line aneurysm formation, which was encountered in ten cases. The aneurysms were often found long after the operation, some of them developing even after more than 20 years. Takayasu arteritis is characterized by extensive inflammation and destruction of the medial elastic fibers and long term postoperative observation is mandatory to improve the late survival rate.

Aortic Aneurysm↗

PubMed1992

[Operative strategy for thoracoabdominal aortic aneurysm with concomitant reconstruction of four main abdominal branches].

A thoracoabdominal aortic aneurysm (TAAA) involving major abdominal branches remains still difficult to be managed. From 1983 to 1990, we successfully operated five such cases. Our operative strategy for TAAA which necessitates concomitant reconstruction of four major abdominal branches is i) to utilize temporary bypass to maintain distal perfusion during aortic cross-clamping, ii) to reconstruct bilateral renal arteries prior to aortic clamping in order to shorten renal ischemic time as much as possible, iii) to reconstruct celiac and superior mesenteric arteries by Crawford's method, iv) to reconstruct two pairs of intercostal arteries by using diagonal anastomosis in the proximal site, and v) to divide the left renal vein temporarily for easy manipulation of renal arteries. All five cases were recovered uneventfully. This procedure, in which the renal ischemic time is saved as short as possible, is considered a safe and reasonable one for thoracoabdominal aortic aneurysms.

Adult↗

PubMed1992

[Long-term patency of aorto-coronary saphenous vein grafts].

One hundred eighty-two cases with 814 aorto-coronary saphenous vein grafts were studied according to coronary risk factors (smoking, hypertension, hyperlipidemia, diabetes mellitus, obesity and family history). The patency rates of all cases were as follows, early-term (within one year after operation): 92.3%, mid-term (within 5 years after operation) 80.7%, long-term (more than 5 years after operation): 66.0%. Coronary risk factors have great influence upon the mid- and long-term patency, especially upon the latter. The long-term patency rate of the grafts complicated with hyperlipidemia was 57.4% and that without hyperlipidemia was 81.8% (p less than 0.01). Hyperlipidemia, complicating 55.5% of all cases, was one of the most influential factors on the patency and also the most difficult one to be controlled. In the United States and Europe, many cases were complicated with hyperlipidemia, and it was considered that the poor patency of the saphenous vein grafts in those countries was due to this fact. Pathological studies revealed that hyperplasia of intima and media, characteristics of venosclerosis, appeared frequently in the saphenous vein grafts having more than three risk factors, and that the factors had effect not only upon arteries but also upon veins. So we conclude that saphenous vein grafts are the materials of good long-term patency, and that the control of the risk factors, particularly hyperlipidemia, is the key to improve the patency.

Adolescent↗

PubMed1992

[Right-sided patent ductus arteriosus with a right aortic arch and right descending aorta].

We experienced an extremely rare anomaly, i.e. right-sided persistent ductus arteriosus with a right aortic arch and right descending aorta. Reviewing the literature, we found only two cases clinically reported in Japan as far as we know. The diagnosis was established by angiography and MRI. We treated the patient successfully through right thoracotomy.

Aorta, Thoracic↗

PubMed1991

[A successful report of emergency CABG for severe calcified thoracic aorta--the porcelain aorta].

The best management for patients requiring CABG with severe calcification of the thoracic aorta has not be established. To clamp ascending aorta in such cases produce cerebral embolization, aortic dissection or mural laceration. We reported a 60-year-old male for unstable angina with LMT lesion. Emergency CABG using IABP was performed with femoral cannulation, moderate hypothermia and induced ventricular fibrillation. His postoperative course was uneventful and coronary arteriography revealed a satisfactory patent graft of the RITA to the LAD system.

Aorta, Thoracic↗

PubMed1991

[Successful report of total aortic root replacement by a new technique].

We employed a new procedure of the total aortic replacement in 2 cases which is made of composite graft and reimplantation of the coronary arteries by direct suture technique. These patients took good clinical course and were discharged after operation. We believe that this procedure is a very useful for annuloaortic ectasia or dissecting aortic aneurysm involved coronary artery with aortic regurgitation.

Aged↗

PubMed1990

Haptoglobin subtyping with anti-haptoglobin alpha chain antibodies.

Specific antibodies against the human haptoglobin (HP) alpha chain were raised and used for immunoblotting after isoelectric focusing to determine Hp alpha subtypes in a reproducible and simplified manner. By eliminating the staining of the HP beta chain, HP alpha subtypes were visualized more precisely and simply than by previously reported methods. Subtypes of a total of 1211 sera, obtained from two different populations in Japan, were examined by the new method. Four HP alpha subtypes (HP 1S-1S,2FS-1S, 2FS-2FS and 2FS-2SS) and five subtypes combined with a new variant (HP 2FS-1V1, 2V1-1S, 2FS-2V1, 2FS-2V2 and 2FS-2V3) were observed. HP 1V1 belonged to HP alpha 1, and HP 2V1, 2V2 and 2V3 belonged to HP alpha 2, and their alleles were designated HP A*1V1, HP A*2V1, HP A*2V2 and HP A*2V3, respectively. The allele frequencies were calculated to be as follows: HP A*1S, 0.2597; HP A*1V1, 0.0004; HP A*2FS, 0.7333; HP A*2SS, 0.0008; HP A*2V1, 0.0045; HP A*2V2, 0.0008; and HP A*2V3, 0.0004. The allele frequency of HP A*2SS, which is common in the European population, is less frequent than HP A*2V1 in the Japanese population.

Alleles↗