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Biomedical subjects

S Shibata

Publications and source records attributed to S Shibata.

At least 901 records · Page 50Linked to original sources
PubMed1979

The chemistry of Chinese drugs.

Some herbal drugs commonly used in Chinese medicine have been studied chemically in correlation with their biological activities. In many cases it has been recognized that some characteristic chemical constituents could represent the therapeutical actions of the drugs. It is noted that elucidation of their chemical structures in view of the structure-activity relationship provides scientific evidence for the beneficial uses of traditional drugs in health care and, furthermore, promotes the discovering of new therapeutics from them. The principles of Chinese drugs are distributed widely among almost all the chemical groups of natural products, for example, simple phenolics, lignan, flavonoid, quinonoid, lower terpenes, triterpenoid, steroid, true alkaloid, protoalkaloid or amines and simple and polymolecular carbohydrates. In the present article, the chemical principles of some important Chinese drugs currently used are discussed mainly on the basis of our own investigations, and we refer to other works for a general understanding of the present status on the chemical approach to studies of Chinese drugs and medicine.

Chemical Phenomena↗
PubMed1979

Effect of stimulation of locus coeruleus on the evoked potential in the amygdala in rats.

Effects of stimulation of the locus coeruleus (LC) on evoked potential in the medial amygdala elicited by stimulation of the olfactory bulb (OB-AME potentials) were studied in the gallamine-immobilized rats. The amplitude of the OB-AME potential was inhibited 27.5% by the conditioning stimulation of LC delivered 30 msec before the test stimulation. The inhibitory effect of LC was reduced by propranolol 5 mg/kg i.p., but not by phentolamine 10 mg/kg i.p.. This effect was also reduced by tetrabenazine 10 mg/kg i.p.. Methamphetamine 5 mg/kg i.p. produced considerable potentiation of the LC inhibitory effect and a reduction of the OB-AME potential itself. These results suggest that the LC plays an inhibitory role in the electrical activity of the medial amygdala.

Amygdala↗
PubMed1979

[Silicone pellet embolization of spinal cord arteriovenous malformation--case report (author's transl)].

This is a report of case with the spinal cord arteriovenous malformation in which silicone pellet embolizations of the feeding arteries were carried out through a percutaneous catheter. The technical details are presented. (Case report) A 35-year-old paraplegic patient. Her radiograms are shown Figs. 1 to 5. An attempt to direct removal of the AVM was limited to the laminectomy (Th1--4) because of extensive haemorrhage in the extradural space. Small silicon pellets with barium sulfate were used to occlude the feeder in this case. The large AVM at the high thoracic level was supplied by feeders coming from the branches of thyreocervical trunk in both side. In the right, six pellets of a proper size were used. Angiogram taken immediately after injection of emboli, demonstrated a decrease of volume of the AVM to about a half (Fig. 2-b), and six months later, the spinal feeders had been embolized almost completely (Fig. 5-a). In the left side, two pellets were injected through the left thyreocervical trunk but the malformation was depicted at the follow-up angiogram taken about six months later. She went to the rehabilitation clinic after surgery and her palaplegia improved remarkably. At present, she can walk on crutches. Disturbances to evacuation and urination have also disappeared.

Adult↗