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Biomedical subjects

S Shaw

Publications and source records attributed to S Shaw.

At least 469 records · Page 26Linked to original sources
PubMed1971

Platelet adhesiveness after blood donation.

Platelet adhesiveness to glass was measured in healthy blood donors at the time of and eight days after donating 500 ml of blood. By a whole blood method a highly significant increase was found whereas by a method using platelet-rich plasma with added adenosine diphosphate there was only a slightly significant increase. The discrepancy suggested that changes in the red cell population might influence the results. Packed red cells from 19 blood donors obtained at the time of donation and eight days later were mixed with fresh pooled platelets from the same independent persons on each occasion. The whole blood platelet adhesiveness on this mixture showed an increase in every case after blood donation. It is postulated that the increased adhesiveness is influenced by the presence of young red cells.

Adenine Nucleotides↗
PubMed1970

Estimation of platelet adhesiveness on whole blood and platelet-rich plasma.

Platelet adhesive tests were carried out in parallel on whole blood and platelet-rich plasma. A column of glass microspherules was used and adenosine diphosphate (ADP) was added to the platelet-rich plasma before passage through the column. Preliminary observations were made to show the effect of the containers and the anticoagulant used. The influence on platelets when stored at 4 degrees C and standing or mixing at room temperature was also assessed. The apparatus used to measure adhesiveness was designed to produce a constant rate of flow through a standard column of glass microspherules. Using both methods, adhesiveness was studied on 70 healthy blood donors. The result showed a significant correlation between the level of adhesiveness found with each technique.

Adenine Nucleotides↗
PubMed1967

Measurement of platelet adhesiveness including the use of diatomaceous silica (celite).

Methods of platelet adhesiveness to glass and celite have been developed. The technical merits of these methods have been compared with a method using adenosine diphosphate (ADP). The aspects of platelet stickiness measured by the various techniques may be somewhat different. Bearing this in mind, the reproducibility of the results using each of the three methods has been assessed on a series of healthy donors.

Adenine Nucleotides↗
PubMed1967

Platelet adhesiveness in diabetes mellitus.

Platelet adhesiveness has been assessed on whole blood from a series of 34 diabetics and 50 control subjects using adenosine diphosphate (A.D.P.) and by adherence to glass microspherules (ballotini). Using both techniques it was possible to demonstrate a significant increase in platelet adhesiveness in the diabetic patients.

Adenine Nucleotides↗
PubMedDate not supplied

Attenuation of the ethanol-induced hepatic redox change after chronic alcohol consumption in baboons: metabolic consequences in vivo and in vitro.

Acute ethanol administration results in increased hepatic NADH/NAD+ ratio and inhibition of galactose elimination, tricarboxylic acid cycle activity, and fatty acid oxidation. To determine how this redox change is affected by chronic alcohol consumption and to assess the resulting metabolic consequences, we studied baboons which were fed alcohol as 50% of their total calories. Redox changes were evaluated through measurement of galactose elimination in vivo and lactate/pyruvate ratios in liver slices in vitro. The metabolic consequences of these changes were assessed through measurement of CO2 production and fatty acid oxidation in liver slices and hepatic lipid accumulation. Chronic alcohol feeding resulted in attenuation of inhibition of galactose elimination, increase in the lactate/pyruvate ratio, and decrease in fatty acid oxidation which were caused by acute ethanol administration. These metabolic adaptations were associated with reduced accumulation of hepatic fat.

Alcohol Oxidoreductases↗