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Biomedical subjects

S Shapiro

Publications and source records attributed to S Shapiro.

At least 451 records · Page 25Linked to original sources
PubMed1982

Diazepam and the risk of breast cancer.

The relation of breast cancer to diazepam use was evaluated in a case-control study of 1236 women with breast cancer and 728 control subjects with other malignancies. Compared to women who never used diazepam, the relative risk for women who used the drug at least 4 days per week for at least 6 months was estimated to be 0.9, with 95% confidence limits of 0.5 and 1.6. There was no apparent association for recent use, or for use in the distant past, although confidence intervals were fairly wide in these categories. The results were not explained by various potential confounding factors, including the major risk factors for breast cancer. The findings suggest that regular diazepam use does not increase the risk of breast cancer relative to other cancers.

Adult↗
PubMed1982

Breast cancer and alcoholic-beverage consumption.

The relation between breast cancer and alcoholic-beverage consumption was evaluated in a case-control study of 1152 women with breast cancer and two groups of control women-519 with endometrial or ovarian cancer, and 2702 with non-malignant disorders. The relative-risk estimate of breast cancer, with allowance for all potential distorting factors, for women who had ever drunk alcoholic beverages relative to those who had never drunk was 1.4 (95% confidence interval, 1.0-2.0) when the comparison group was the group with endometrial or ovarian cancer and 1.9 (1.5-2.4) when the controls who had non-malignant disorders were the comparison group. The association was evident for beer, wine, and spirits. The association was not explained by any of the major known risk factors for breast cancer, but we had no information on dietary factors. The findings support the hypothesis that alcohol consumption, or related dietary factors, increases the risk of breast cancer.

Adult↗
PubMed1982

Acetaminophen and aspirin. Prescription, use, and accidental ingestion among children.

Among 3,587 hospitalized children monitored by the Pediatric Drug Surveillance Program between 1974 and 1979, acetaminophen was prescribed for 32% and aspirin for 3%. In the three months before admission, 23% reported use of either drug. In both inpatient and preadmission settings, acetaminophen use increased between 1975 and 1977 and decreased subsequently. Aspirin prescriptions were consistent over the entire study period among inpatients, but preadmission use decreased substantially. The Massachusetts Poison Information Center observed a 36% increase in calls concerning aspirin from 1976 to 1977 and 1977 to 1978, similar to the increase in all calls, but acetaminophen calls increased by 87%. Long-standing concerns about the toxic effects of aspirin, coupled with recent concerns about hepatotoxic effects of acetaminophen in overdose, may be leading physicians and parents to decrease the use of both drugs for the treatment of fever.

Acetaminophen↗
PubMed1982

Mortality and morbidity in infants with intrauterine growth retardation.

This report is based on an analysis of the experience with all births in several urban and rural areas of the United States. All infants whose birth weight was in the lowest quartile for their week of gestation were designated as small for gestational age regardless of their birth weight or length of gestation; other infants were considered appropriate for gestation age. We interpret the data to indicate that appropriate-for-gestational age and small-for-gestational age infants, all of low birth weight, differ in the nature of their risk for adverse outcome as determined by an assessment at one year of age, although both are at approximately equal risk of adverse outcome overall. In each weight group, the total proportion of infants who either died before one year of age or were handicapped at one year of age was similar for small-for-gestational age and appropriate-for-gestational age infants, but appropriate-for-gestational age infants were at greater risk of neonatal death and small-for-gestational age infants were at greater risk of problems manifested during the first year of life or at one year of age. As the findings are based on data obtained from entire populations (rather than from infants born in particular hospitals), they are likely to be generalizable.

Age Factors↗
PubMed1982

Airport wandering as a psychotic symptom.

It appears that wandering at airports can be the expression in certain psychotic patients whose conflicts relate to separation and reunion as a major area of disturbance. The case reports presented demonstrate a causal relationship between attraction to the airport setting and ideas relating to abandonment and reuniting with family. The patients whose symptoms are focused in these settings may be found wandering in various airports around the world.

Acute Disease↗
PubMed1982

Prospects for eliminating racial differences in breast cancer survival rates.

Results from the randomized trial underway in the Health Insurance Plan of Greater New York to determine the efficacy of periodic screening with mammography and palpation of the breast have been examined to determine the effect of screening on racial differences in breast cancer survival rates. Consistent with experience in general populations, the control group showed a lower five-year survival rate among non-White women with breast cancer than among White women. In the study group, 65 per cent of whom participated in the screening program, there was no differential in the survival rates of the two racial groups. The elimination of the unfavorable status among non-Whites through screening does not appear to be explained by various artifacts explored. Secondary prevention measures may offer the possibility of reducing or closing the gap in breast cancer survival rates between White and non-White women.

Adult↗
PubMed1982

Aspirin and myocardial infarction in young women.

To assess whether aspirin reduces the risk of a first myocardial infarction (MI) in young women, we evaluated data from a case-control study among women less than 50 years of age without a prior MI: 48 of 551 cases of MI and 67 of 896 hospital controls had taken aspirin regularly for at least 12 weeks immediately before admission. The relative risk estimate was 0.8 upon allowance for confounding factors but it was not statistically significant (95 per cent confidence interval, 0.5-1.4). These data alone do not provide evidence of protection by aspirin against a first infarction in young women.

Adult↗
PubMed1982

Ten- to fourteen-year effect of screening on breast cancer mortality.

Results from the randomized trial conducted by the Health Insurance Plan (HIP) to determine the efficacy of breast cancer screening with mammography and palpation are reported for longer periods than previously available. By the end of 10 years after entry, the study group's mortality due to breast cancer was about 30% below the control group's. Arithmetic gains due to screening were maintained through year 14; relative gains declined. With increases in the period of follow-up, cumulative survival rates among cases detected by mammography alone (palpation negative during screening), decreased more rapidly than rates among other subgroups, but survival rates for mammography cases remained relatively high. Study women aged 40-49 years at entry began to show lower breast cancer mortality than those in the control group as duration of follow-up increased. Reservations are advanced about the acceptance of this finding as evidence of the efficacy of screening under age 50 under the conditions of the HIP study. The reservations are based on the observation that the decrease of mortality among the study group aged 45-49 at entry is concentrated entirely among cases diagnosed after they reached 50 years of age.

Adult↗
PubMed1982

In-hospital maternal mortality in the United States: time trends and relation to method of delivery.

To study time trends in maternal mortality in the United States and to attempt to compare the risk of cesarean with vaginal delivery, information from the Professional Activities Study of the Commission on Professional and Hospital Activities for 3 years-1970, 1974, and 1978-was reviewed. For all deliveries, mortality per 100,000 deliveries declined from 25.7 in 1970 to 14.3 in 1978. For vaginal deliveries, mortality per 100,000 deliveries declined from 20.4 to 9.8. For cesarean deliveries, mortality per 100,000 births decreased more than for vaginal deliveries, from 113.8 to 40.9. Mortality for deliveries with no mention of complications, lacerations, or uterine rupture declined significantly from 1970 to 1978. Mortality for deliveries complicated by dystocia or malpresentation declined significantly from 1970 to 1974, but failed to decline thereafter. Mortality for deliveries complicated by a previous cesarean or by antepartum hemorrhage did not decline significantly from 1970 to 1978. For all complications with a sufficient number of vaginal and cesarean deliveries, except deliveries complicated by malpresentation or antepartum hemorrhage, mortality was at least twice as high in cesarean as in vaginal deliveries. Based on a comparison of mortality after a previous cesarean with mortality for all vaginal deliveries with no complication, the authors conclude that cesarean delivery is probably neither less than 2 nor more than 4 times more hazardous than vaginal delivery.

Adolescent↗
PubMed1982

Factors associated with maternal opinion of infant development--clues to the vulnerable child?

A mother's expectations about the development of her infant have been found to be a strong determinant of child development, but little is known about the factors that may affect maternal assessment of development. In this study, the relationship of the mother's opinion of the development of her infant with several sociodemographic, antenatal, intrapartum, and infant health variables was examined for a large sample of 1-year-old infants for whom gross motor observations were also obtained at the time of the interview. Among those observed to be developing at an appropriate rate, 4.0% were perceived by their mothers as developing more slowly than the mothers considered normal; among infants developing more slowly, 28.6% were considered to be developing slowly by their mothers. In both groups the major determinants of maternal opinion of slow development concerned the infant's health: low birth weight, congenital anomalies regardless of severity, hospitalization during the first year of life, and high ambulatory care use. These results indicate that maternal perception of infant development may not reflect the infant's level, but past or present illness, and raise questions about the influence of infant health on maternal-infant interactions and the effect of such interactions on subsequent development in the child.

Adolescent↗