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S Shadomy

Publications and source records attributed to S Shadomy.

97 records · Page 6Linked to original sources
PubMedDate not supplied

Comparative in vitro antifungal susceptibility studies with 30 serotype A and B isolates of Candida albicans.

Fifteen isolates, each of serotypes A and B of Candida albicans, were tested in vitro against flucytosine, amphotericin B, and cilofungin. All 15 serotype A isolates were susceptible to all three drugs. Three serotype B isolates were resistant to flucytosine. Two isolates, one serotype A and one serotype B, had elevated amphotericin B and cilofungin MICs of 5 micrograms/ml.

Amphotericin B↗
PubMedDate not supplied

Urinary tract infections due to Candida albicans.

Infection of the urinary tract due to Candida albicans is an uncommon but well-described complication of modern therapeutics. Despite the rarity of this infection, culture of properly collected urine yielding C. albicans requires an explanation. The significance of systemic factors in the defense of the urinary tract against candidal infection is unknown, but secretions from the prostate gland in men and from periurethral glands in women have been reported to be fungistatic. In addition, growth of Candida at sites on mucous membranes may be suppressed by other normal flora. Conditions that predispose to candiduria include diabetes mellitus, antibiotic and corticosteroid therapy, as well as factors such as local physiology and disturbance of urine flow. Lower urinary tract candidiasis is usually the result of a retrograde infection, while renal parenchymal infection most often follows candidemia. In addition to asymptomatic candiduria, recognized clinical forms of candidal urinary tract infections include bladder infection, renal parenchymal infection, and infections associated with fungus ball formation. Unfortunately, clinical criteria alone are insufficient to distinguish reliably among these clinical types. If the urine is found to contain candidal organisms, the condition of the patient should be considered for determination of appropriate therapy. When infection is thought to be confined to the bladder, patients without indwelling bladder catheters should be considered for flucytosine therapy. For patients requiring indwelling bladder catheterization, irrigation with amphotericin B is usually successful. Although flucytosine alone may be useful for renal parenchymal candidal infection, iv amphotericin B alone or the combination of amphotericin B and flucytosine is indicated when systemic candidiasis cannot be excluded.

Adrenal Cortex Hormones↗
PubMedDate not supplied

Cryptococcosis in renal transplant patients.

First, cryptococcal infections in transplant patients can be readily diagnosed and successfully treated; aggressive, innovative uses of currently available drugs should accomplish this. Second, some drug related toxicity, mostly nephrotoxicity and hematologic, is inevitable, and patients must be carefully monitored so that these effects may be minimized. Third, anti-fungal drug assays are available and can be performed and drug levels should be monitored, with the object of obtaining levels which are both reasonably safe and maximally effective in terms of known in vitro susceptibilities of the offending pathogen.

Adult↗