[Liver and diabetes: nutritional and metabolic relationships between metabolic hepato-cholecystopathies and the diabetic syndrome].
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Adult↗
Biomedical subjects
S Seri
Publications and source records attributed to S Seri.
Variations of the enzymatic activity of the rat's gum glycolytic cycle following administration of sweeteners.
The effects of saccharose and isomalt on the rat's gum carbohydrate metabolism have been studied through evaluation of the activity of hexokinase (HK), phosphoglucoisomerase (PGI), lactatedehydrogenase (LDH), glucose-6-phosphate-dehydrogenase (G6PD), phosphofructokinase (PFK) and phosphoglucomutase (PGM). The values obtained by administering a drink sweetened with 10% isomalt are significantly lower (p < 0.05) than those obtained in the animals that had the drink sweetened with 10% saccharose. Administration of the same amount of drinks through gastric tube showed an enzymatic activity similar to that of the rats in the control group. Intermediate metabolites of the glycidic metabolism would then be responsible for the lesions of the oral epithelium, as those obtained by administering high levels of vitamin A, through an increased synthesis of acids. The increase of HK, PFK and PK activity with respect to the control group in those rats that had the isomalt on the rat's gum glycolytic cycle enzymes was found to be lower than that detected for other polyalcohols.
Animals↗
Blackcurrant seed oil, zinc, and fetal alcohol syndrome.
The effects of dietary supplementation by blackcurrant seed oil (BSO) and zinc sulphate on PGI2 gastric release and on serum zinc levels were investigated in 50 pregnant Sprague-Dawley rats which received watery alcohol solutions from 5% to 30% (v/v) as well as in their newborns. Blood zinc was assayed by atomic absorption spectroscopy; PGI2 was evaluated by platelet aggregation PGI2-dependent test. Dietary supplementation by BSO increased gastric release of PGI2 both in the mothers and their newborns; blood zinc levels were significantly (p < 0.01) lower in both vs control. The content of PGI2 in the stomachs was significantly (p < 0.01) higher in the mothers treated by zinc sulphate vs their new-borns. Protection of gastric mucosa of the new-born rats from alcohol fetal exposure might depend on polyunsaturated fatty acids (PUFA) dietary supplementation, because of the capability of PUFA to cross placenta; the efficacy in the protection might be monitored by platelet aggregation PGI2-dependent test.
Administration, Oral↗