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Biomedical subjects

S Seltzer

Publications and source records attributed to S Seltzer.

At least 37 records · Page 2Linked to original sources
PubMed1989

An evaluation of the biocompatibility of a glass ionomer-silver cement in rat connective tissue.

Pellets of a glass ionomer-silver cement and a zinc oxide-eugenol cement were implanted into the soft tissues and bones of 30 rats. Following experimental periods of 14, 30, and 80 days, the animals were killed and tissue sections were prepared. The responses to each of the materials initially and at 30 days consisted of mild inflammation. No severe inflammatory responses were noted in any of the groups. By 80 days, although mild inflammation persisted, the materials appeared to be well tolerated. Bone apposition occurred in the glass ionomer-silver cement group; the zinc oxide-eugenol group produced fibrosis.

Animals↗
PubMed1989

[Endodontic microbiology: antimicrobial canal medications].

Medicaments used for reducing or eliminating microorganisms from infected root canals include: irrigating solutions, such as sodium hypochlorite, urea peroxide and hydrogen peroxide, chloramine, iodine-potassium-iodide solution, and chlorhexidine solution. In addition, various intracanal drugs, such as calcium hydroxide and antibiotics, are in use. The characteristics of these drugs are discussed.

Anti-Bacterial Agents↗
PubMed1989

cis-beta-acetylacrylate is a substrate for maleylacetoacetate cis-trans isomerase. Mechanistic implications.

Maleylacetoacetate cis-trans isomerase together with coenzyme glutathione catalyzes cis-trans isomerization of cis-beta-acetylacrylate strongly suggesting that the isomerase directly catalyzes isomerization of the diketo forms in addition to the ketoenol forms of maleylacetone and maleylacetoacetate. The isomerase exhibits wider substrate acceptance than previously thought.

Fatty Acids, Monounsaturated↗
PubMed1986

Pain in endodontics.

Explore the source record for details and available documents.

Bacterial Physiological Phenomena↗
PubMed1986

Perilymph fistula: the Iowa experience.

Ninety-one patients with demonstrable perilymph fistulas presented with an amazing array of signs and symptoms ranging from unilateral tinnitus and aural fullness to sudden-and-profound hearing loss, roaring tinnitus, and whirling vertigo. Between 1977 and 1984, 214 exploratory tympanotomies for suspected perilymph fistula (PLF) were performed on 177 patients. One hundred six primary (initial) fistulas were found in 95 ears and 26 recurrent fistulas were identified. Eighty-two percent of the 91 patients with PLF had auditory symptoms, 8% with auditory symptoms as the sole complaint. Eighty-one percent of the patients had vestibular symptoms, 12% with vestibular symptoms alone. The type of hearing loss and the nature of the vestibular symptoms were widely variable. Of the 58 patients with preoperative auditory symptoms, 49% had improved hearing (23% improved to serviceable range), after closure of PLFs. Ninety-five percent of the patients who presented with vestibular symptoms had elimination of or decrease in their dizziness to the extent that it no longer interfered with their daily activities. The highest incidence of recurrent fistula was associated with grafts using fatty tissue. Patients with Mondini deformity were at particularly high risk for fistula recurrence.

Adolescent↗
PubMed1983

Single agent chemotherapy for head and neck cancers. The murine subrenal capsule assay.

The murine subrenal capsule assay was used to determine chemotherapeutic sensitivities of metastatic, primary, or recurrent head and neck cancers. Tumor fragments (1 cu mm) were implanted under the renal capsule of 2- to 4-month-old normal female C57 BL/6 X DBA/2 F1 hybrid mice. Xenografts included 20 squamous cell carcinomas (SCCs), one mucoepidermoid carcinoma, one adenoid cystic carcinoma, and two melanomas. Groups of tumor-bearing mice were treated with chemotherapy daily for five days. Sensitivities of the tumor were assessed on day 6 by comparison of final implant size with initial implant size. Significant oncolytic activity was detected against 16 of 24 tumors (14 of 20 SCCs and both melanomas). Correlations between the in vivo assay and clinical studies are needed to determine its predictive value.

Animals↗
PubMed1983

Light-dependent nitration of bacteriorhodopsin.

Purple membranes were treated with tetranitromethane to modify tyrosine residues of bacteriorhodopsin. At pH 8.0, nitration is shown to be affected by illumination during the modification. Amino acid analysis revealed about 0.7 residues nitrated if reaction was in the dark while about 2.0 tyrosines were modified if illumination greater than 540 nm was provided. Tryptophan was unaffected under both conditions. Light-dependent nitration caused a blue shift of the absorbance maximum of bacteriorhodopsin from 568 to 530 nm while no chromophore shift was observed for the dark-modified preparation. Both preparations show an absorption band at 360 nm indicative of the presence of nitrotyrosines. Reduction by dithionite eliminated the pH-dependent changes associated with the 360-nm nitrotyrosine band. Circular dichroism spectra indicate that interactions between neighboring chromophores are altered concomitant with the blue shift of the absorbance maximum by nitration. These studies show that light is required for the nitration of the tyrosine residue, and that Tyr 26 (H. D. Lemke and D. Oesterhelt (1981) Eur. J. Biochem. 115, 595-604) is probably responsible for the blue shift of the absorbance maximum. The intrinsic fluorescence and photocycle kinetics of the tyrosine-modified preparation and reduction of nitrotyrosine by dithionite were studied. In dark modification, only pH-dependent dithionite-reducible nitrotyrosines were produced. It is concluded that surface tyrosines probably do not directly participate in the proton-translocation events coupled to the photocycle of bacteriorhodopsin.

Bacteriorhodopsins↗
PubMed1983

Thermography and oral inflammatory conditions.

A brief review of the literature on the use of thermography in medicine and dentistry is presented. This is followed by the presentation of eleven case reports of the use of thermography in dental clinic patients with various oral inflammatory conditions. The results showed that in seven of the eleven cases the thermogram was able to delineate the involved from the noninvolved side. The findings were nonspecific, however, and in its current form thermography cannot be used alone for differential diagnosis.

Cellulitis↗
PubMed1983

Upper rib fractures and mediastinal widening: indications for aortography.

Survival of patients with posttraumatic thoracic aortic rupture depends on early diagnosis. It is frequently stated that fracture of the first or second ribs and mediastinal widening are findings suggestive of thoracic aortic rupture. We found that the probability of sustaining thoracic aortic rupture is the same for patients with upper rib fractures as for those with other rib fractures (1/64 versus 5/149; p = 0.85). Also, our data fail to show a statistical difference in the incidence of thoracic aortic rupture associated with upper (first and second) rib fractures compared with no rib fracture at all (1/64 versus 9/304; p = 0.85). Thus, patients with thoracic aortic rupture are not more likely to have rib fractures (7/21 versus 14/21; p = 0.15), and if a rib fracture is present, the probability of it being at the upper level is the same as that for a fracture at any other level (1/7 versus 6/7; p = 0.06). Ratios of mediastinal width to chest width were used as a measure of mediastinal widening, and were found to be an accurate predictor of thoracic aortic rupture. Ratios greater than 0.28 at the aortic knob were 100% specific and 85% sensitive for this condition.

Aorta, Thoracic↗
PubMed1983

Computerized tomography scan for diagnosis and staging of renal cell carcinoma.

A comparison of computerized tomography and arteriography for the diagnosis and staging of renal cell carcinoma was done in 45 patients during a 2-year interval. Compared to arteriography, computerized tomography was more accurate in the diagnosis of renal cell carcinoma (95 versus 85 per cent), equivalent in the determination of renal vein involvement and superior in the determination of regional nodal involvement. Because of the increased diagnostic accuracy, better delineation of the local extent of the tumor and less invasive nature we recommend computerized tomography as the preferred procedure for diagnosis and staging of renal cell carcinoma. However, in patients with questionable findings arteriography and/or inferior venacavography should be used as complementary studies.

Adenocarcinoma↗