Search PubMed⌕ Search

Biomedical subjects

S Schultz

Publications and source records attributed to S Schultz.

At least 91 records · Page 5Linked to original sources
PubMed1993

Transcutaneous oxygen pressure. An effective measure for prosthesis fitting on below-knee amputations.

After amputation for arterial occlusive disease of the lower limbs, healing and local adaptation to a prosthesis depend on the oxygen ratio in the tissue. Transcutaneous oxygen tension (TcPO2) is a noninvasive microcirculatory exploration. Forty six below-knee stumps were selected without any prosthetic problem excepting vascular, with a follow-up mean duration of 23 months. They were classified into different prosthetic categories. The first was the worst because it required further amputation on the thigh and the fourth the best, which displayed complete adaptation to a socket contact. These groups were related to their TcPO2 values on the anterior and exterior face of the stumps in both reclined and seated positions. It seems that it is impossible to achieve healing when the TcPO2 value is lower than 15 mm Hg in lying position. However, healing is possible above 20 mm Hg but socket contact is not possible when TcPO2 values are under 40 mm Hg. When TcPO2 values are above 40 mm Hg, a good prosthesis fitting is possible when no problems are encountered other than vascular ones.

Aged↗
PubMed1992

Adult onset of renal angiomyolipoma in a patient with tuberous sclerosis.

The growth of renal angiomyolipomas in adult tuberous sclerosis patients has not been previously reported. We report one such case of the growth of an angiomyolipoma in a previously documented angiographically normal appearing kidney after the contralateral kidney was removed for angiomyolipoma 15 years earlier.

Adult↗
PubMed1992

Abortions and HIV-1 infection in New York City, 1987-1989.

OBJECTIVE: This serologic survey was performed to determine rates of HIV-1 infection among New York City (NYC) women seeking abortions. DESIGN: Anonymous unlinked blood samples were collected and analyzed for the presence of HIV-1 antibodies. Abortion clinics were chosen for the representativeness of their patient population to all women obtaining abortions in NYC. SETTING: Blood samples and demographic information, including age group, race/ethnicity, borough of residence and type of payment were obtained from 15 abortion sites (11 clinics, four hospitals) in NYC between 1987 and 1989. PARTICIPANTS: A total of 5889 blood samples were collected from women seeking abortions. Twelve of the 15 facilities were sampled in all 3 years. MAIN OUTCOME MEASURES: We determined HIV infection rates in the overall sample and in selected subpopulations, and assessed temporal trends. Stepwise logistic regression was applied to identify factors independently associated with HIV-1 infection. RESULTS: The rate of HIV-1 infection in the overall sample was 1.19% (70 out of 5889) and remained stable in the 12 facilities sampled during all 3 years: 1987 (1.42%, 17 out of 1200); 1988 (1.67%, 20 out of 1200); and 1989 (0.90%, 27 out of 2989) (P = 0.09). Logistic regression identified receiving Medicaid and being aged between 25 and 35 years to be independently associated with HIV-1 infection. CONCLUSION: Approximately 1200 women seeking abortions annually in NYC are infected with HIV-1. If accessibility to elective abortion is curtailed, the number of children born to HIV-1 infected mothers will increase.

Abortion Applicants↗
PubMed1992

Occupational adaptation: toward a holistic approach for contemporary practice, Part 2.

This paper introduces a practice model based on the occupational adaptation frame of reference (Schkade & Schultz, 1992). The occupational adaptation practice model emphasizes the creation of a therapeutic climate, the use of occupational activity, and the importance of relative mastery. Practice based on occupational adaptation differs from treatment that focuses on acquisition of functional skills because the practice model directs occupational therapy interventions toward the patient's internal processes and how such processes are facilitated to improve occupational functioning. The occupational adaptation practice model is holistic. The patient's occupational environments (as influenced by physical, social, and cultural properties) are as important as the patient's sensorimotor, cognitive, and psychosocial functioning and the patient's experience of personal limitations and potential is validated. The integration of these concepts drives the treatment process. Through a description of treatment with a variety of patients, this paper presents the model's diversity and illustrates the relationship between the concepts. The occupational adaptation practice model reflects the uniqueness of occupational therapy and integrates the profession's historical practice with contemporary interventions and methods.

Activities of Daily Living↗
PubMed1992

Occupational adaptation: toward a holistic approach for contemporary practice, Part 1.

A theoretical perspective designed for clinical application and based on fundamental occupational therapy principles is offered. This perspective, the occupational adaptation frame of reference, is presented as an articulation of (a) a normal developmental process leading to competence in occupational functioning; (b) the process through which the benefits of occupational therapy occur; and (c) a perspective that promotes holistic practice. The person is viewed as operating occupationally through an idiosyncratic configuration of sensorimotor, cognitive, and psychosocial systems, all of which are inevitably involved in each occupational response. This occupational functioning is described as occurring through interaction of the person with a work, play and leisure, or selfcare context that has distinctive physical, social, and cultural properties (i.e., the occupational environment). Occupational adaptation is a perspective that can influence practice, education, and research.

Adaptation, Psychological↗
PubMed1992

A new era dawns for the University Hospital Consortium. Interview by Carolyn Dunbar.

A group of 60 university hospitals and medical centers has evolved from its original goal of gaining greater purchasing clout to a new goal: The University Hospital Consortium is becoming an information corporation, with the enormous information potential to affect treatment outcomes, practice patterns and clinical research. Sam Schultz, UHC's vice president of Information Services, tells Computers in Healthcare his organization is on the verge of a new age of discovery.

Costs and Cost Analysis↗
PubMed1991

Phase II trial of cimetidine in metastatic melanoma. A Hoosier Oncology Group trial.

Fifteen evaluable patients with metastatic malignant melanoma who had received no prior chemotherapy were treated with high-dose cimetidine orally, 600 mg q.i.d. Although three patients had stable disease lasting 2-4 months, there were no objective responses. Median survival was 5.3 months (range 1-18 months). Toxicity was essentially negligible except for severe diarrhea in one patient and worsening liver function abnormalities in another. High-dose cimetidine does not have any significant activity in metastatic melanoma.

Administration, Oral↗
PubMed1991

Relationships between intracellular amino acid levels and protection against injury to isolated proximal tubules.

Metabolism and cellular levels of glycine, alanine, and other relevant amino acids in proximal tubules were studied during models of acute injury and protection by glycine. Freeze-clamped, normal rabbit renal cortex was very rich in glycine (66.8 nmol/mg protein) and glutamate and also had substantial levels of taurine, alanine, glutamine, serine, and aspartate. Isolated proximal tubules were severely depleted of all these amino acids (glycine, 2.1 nmol/mg protein). During 37 degrees C incubation in presence of alanine, tubules recovered only glutamate to a level approximating that in vivo (38.8 nmol/mg protein, 15.2 mM). Glycine added to medium at levels ranging from 0.25 to 2 mM was actively concentrated four- to sixfold by tubule cells. Two millimolar glycine potently protected tubules from lethal cell injury induced by hypoxia, antimycin A, or ouabain. Glycine levels of injured tubules rapidly equilibrated with medium, irrespective of whether glycine was loaded by preincubation or was added concomitantly with the injury maneuver. Metabolism of glycine during protection, assessed by changes in total levels, gas chromatography-mass spectroscopy determination of the fate of [13C]glycine, and redistribution of label from [3H]glycine was minimal. The data suggest that glycine plays an essential, constitutive role in maintenance of tubule cell structural integrity independently of common metabolic pathways. Intracellular amino acid content is sufficiently labile for depletion of structurally essential amino acids to potentially occur in a variety of settings, but, even with severe ATP depletion or Na+ pump inhibition, supplemental glycine is readily available to intracellular sites of action.

Amino Acids↗
PubMed1991

The association between congenital syphilis and cocaine/crack use in New York City: a case-control study.

From 1987 to 1989, an epidemic of congenital syphilis was observed in New York City. A case-control study was done to assess the association between various maternal risk factors and congenital syphilis. Independent of the effect of other factors, the odds of being exposed to cocaine were 3.9 times greater among cases than controls (95% confidence interval, 2.8-5.3). This study suggests that the epidemic of congenital syphilis may be related to the increase in cocaine/crack use among delivering mothers.

Alcohol Drinking↗