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Biomedical subjects

S Schenk

Publications and source records attributed to S Schenk.

97 records · Page 6Linked to original sources
PubMed1976

[Intrathecal cortison injection in lumbar disc problems (author's transl)].

Intrathecal instillation of corticosteroid was used in treatment of 188 patients with persistent sciatica or lumbar pain caused by disc hernia or osteochondrosis and recurrent sciatica or lumbar pain after disc operation. 88 of 122 own patients were followed up. Indication, mechanism of steroid action, technic, complications and results are discussed. According to the good results in part of the patients, still after years, the authors believe, that intrathecal corticosteroid administration is a further useful method of conservative treatment of degenerative lumbar disc affections. This therapy can also be used in patients with recurrent, persistent lumbar or leg pain after disc operation.

Adult↗
PubMedDate not supplied

Variability in subjective responses to cocaine: initial experiences of college students.

Eighty psychology students were administered a short self-report questionnaire that probed their initial and most recent experiences with cocaine. Most of the subjects were relatively inexperienced with cocaine; only five had used the drug more than 40 times. Measures of Global Positive and Global Negative responses to cocaine use were obtained. There was substantial variability in the response to cocaine on both the positive and negative effects scales, although there was no relationship between the magnitude of these self-reported effects of cocaine. The initial Global Positive (but not Global Negative) scores were correlated with latency to next use of cocaine and with lifetime use of the drug, suggesting that abuse potential of the drug is related to magnitude of initial positive effect. These data suggest that studies on predisposing factors in cocaine abuse should examine the basis for the variability in initial response to cocaine.

Adolescent↗
PubMedDate not supplied

Variability in subjective responses to marijuana: initial experiences of college students.

A short self-report questionnaire that probed initial and most recent experiences with marijuana was administered to 197 undergraduate psychology students. Measures of Global Positive and Global Negative responses to marijuana use were obtained. There was substantial variability in the response to marijuana on both of these scales, which were moderately correlated with each other. The self-reported Global Positive score for initial use of marijuana was correlated with latency to next use of marijuana and with lifetime use of the drug, suggesting that abuse potential of the drug is related to magnitude of initial positive effect. Self-reported Global Negative scores for initial use did not correlate with either of these outcome measures. These data are compared and contrasted to those from a study that examined these responses to cocaine. The findings suggest that the abuse potential for both of these drugs is related to the magnitude of the positive response to first use.

Adolescent↗
PubMedDate not supplied

Age-dependent effects of isolation housing on the self-administration of ethanol in laboratory rats.

Studies of the influence of housing conditions on ethanol self-administration have been inconsistent, with findings that isolation housing increases, decreases or produces no effects on ethanol intake. One possible explanation for these discrepant findings is that the effects of housing are dependent on the age at which the manipulation is performed. In the present experiment rats were housed from weaning or from age 65 days in either an isolated or grouped condition. After 12 weeks, they were tested for the voluntary oral self-administration of ethanol. Although all rats consumed comparable quantities of ethanol when lower concentrations were available, the rats isolated from weaning consumed significantly greater amounts of more concentrated ethanol than their group-housed counterparts. In contrast, there was no difference in ethanol consumption between isolated and grouped rats when they were differentially housed at maturity. These data suggest that an important determinant of ethanol intake in rats is related to environmental factors and that the influence of these factors is age-dependent.

Aging↗