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S Schaller

Publications and source records attributed to S Schaller.

48 records · Page 3Linked to original sources
PubMed1999

[Micro-CT. Technology and application for assessing bone structure].

The strength and fracture resistance of bone is determined by the structure of the trabecular network and the cortical shell. While standard 2D techniques like histomorphometry are inadequate to assess the 3D nature of the trabecular network, isotropic 3D datasets of this network can be acquired with the new imaging modality of microCT. However, so far the quantitative analysis of the generated datasets, in particular the extraction of appropriate parameters describing the bone structure, has not been finally solved. In this article we describe the technology and applications of microCT systems relevant in the field of osteology. The most important technical features of current microCT systems in this context are: 1. A spatial resolution down to 5-10 microns can be achieved. 2. The maximum sample size is related to the desired resolution by a factor of approximately 1000, that is, a resolution of 10 microns limits the maximum sample size to approximately 1 cm. 3. Scan times for microCT systems vary between minutes and hours. Currently five areas for the application of microCT systems in osteology can be identified: 1. The search of parameters characterizing the 3D trabecular structure. 2. The application of finite element models to determine the biochemical competence of the structural parameters. 3. The use of microCT in preclinical trials to study drug effects in small animals. 4. The validation of analysis methods used in high-resolution in-vivo imaging systems. 5. The 3D quantification of modeling and remodeling processes.

Adult↗
PubMed1999

[The technical bases and uses of multi-slice CT].

In this review the technical principles and applications of multi-slice CT are discussed. Multi-slice CT systems allow simultaneous acquisition of up to 4 slices by using multi-row detector systems. Intuitive geometrical arguments are used to establish the limitation to a maximum of 4 slices which is kept by all currently existing multi-slice CT systems. Two different construction principles of the detector are discussed, the "Fixed Array" detector and the "Adaptive Array" detector. The extension of conventional 360 LI and 180 LI spiral interpolation techniques to multi-slice spiral CT is explained as well as a new generalized multi-slice spiral weighting concept, the so-called "Adaptive Axial Interpolation". Several techniques to improve multi-slice spiral image quality are discussed. Finally, some examples for clinical applications are given, and the principle of ECG triggered and ECG gated cardiac examinations with optimized temporal resolution is presented. Multi-slice CT systems are a milestone with respect to increased volume coverage, shorter scan times, improved axial (longitudinal) resolution and better use of the X-ray tube output. Additionally, new clinical applications are possible such as Cardiac CT.

Electrocardiography↗
PubMed1999

Subsecond multi-slice computed tomography: basics and applications.

The recent advent of multislice-scanning is the first real quantum leap in computed tomography since the introduction of spiral CT in the early 90s. We discuss basic theoretical considerations important for the design of multislice scanners. Then, specific issues, like the design of the detector and spiral interpolation schemes are addressed briefly for the SOMATOM PLUS 4 Volume Zoom. The theoretical concepts are validated with phantom measurements. We finally show the large potential of the new technology for clinical applications. The concurrent acquisition of multiple slices results in a dramatic reduction of scan time for a given scan technique. This allows scanning volumes previously inaccessible. Similarly, given volumes can be scanned at narrower collimation, i.e. higher axial resolution in a given time. From data acquired at narrow collimation, both high-resolution studies and standard images can be reconstructed in the so-called Combi-Mode. This on the one hand reduces dose exposure to the patient because repeated scanning of a patient is no longer required. On the other hand, standard reconstructions benefit from narrow collimation as Partial Volume Artifacts are drastically suppressed. The rotational speed of 0.5 s of the SOMATOM PLUS 4 Volume Zoom furthermore opens up a whole range of new applications in cardiac CT. For the first time, virtually motion-free images can be acquired even for large volumes in a single breathhold by the combination of fast rotation and ECG triggering, respectively gating. We explain the underlying concepts and present initial results. The paper concludes with a brief discussion of the impact of the new technique on image display and postprocessing.

Artifacts↗
PubMed1998

Acute nonoliguric renal failure in children associated with nonsteroidal antiinflammatory agents.

OBJECTIVE: Acute renal failure is commonly seen in adults after treatment with nonsteroidal antiinflammatory agents. This complication has rarely been reported in children. DESIGN: Four consecutive patients admitted with acute nonoliguric renal failure associated with ingestion of nonsteroidal antiinflammatory agents. SETTING: The emergency department and ward units at The Children's Hospital of Philadelphia. PATIENTS: Four patients, ages 3.5 to 19 years. INTERVENTIONS: Appropriate evaluations including measurement of serum creatinine concentrations in the emergency department and careful histories of drug ingestion. MAIN OUTCOME MEASURE: Rapid return to normal serum creatinine concentrations. RESULTS: Four patients were admitted to The Children's Hospital of Philadelphia between May 1996 and June 1997 with a diagnosis of acute, nonoliguric renal failure following ingestion of nonsteroidal antiinflammatory agents. None of the patients had features of hemolytic uremic syndrome, systemic lupus, dehydration, obstructive uropathy or sickle cell disease. Each patient had ingested nonsteroidal antiinflammatory agents before the onset of acute renal failure. None had oliguria or anuria, dehydration, abnormal serum electrolyte concentrations, or evidence of glomerulonephritis. One patient also had a urinary tract infection that was treated with antibiotics. Another patient was treated with methylprednisolone and prednisone. None was biopsied. Three recovered completely. CONCLUSION: With the increasing use of over-the-counter nonsteroidal antiinflammatory agents, this association may become more prevalent.

Acute Kidney Injury↗
PubMed1998

An efficient Fourier method for 3-D radon inversion in exact cone-beam CT reconstruction.

The radial derivative of the three-dimensional (3-D) radon transform of an object is an important intermediate result in many analytically exact cone-beam reconstruction algorithms. We briefly review Grangeat's approach for calculating radon derivative data from cone-beam projections and then present a new, efficient method for 3-D radon inversion, i.e., reconstruction of the image from the radial derivative of the 3-D radon transform, called direct Fourier inversion (DFI). The method is based directly on the 3-D Fourier slice theorem. From the 3-D radon derivative data, which is assumed to be sampled on a spherical grid, the 3-D Fourier transform of the object is calculated by performing fast Fourier transforms (FFT's) along radial lines in the radon space. Then, an interpolation is performed from the spherical to a Cartesian grid using a 3-D gridding step in the frequency domain. Finally, this 3-D Fourier transform is transformed back to the spatial domain via 3-D inverse FFT. The algorithm is computationally efficient with complexity in the order of N3 logN. We have done reconstructions of simulated 3-D radon derivative data assuming sampling conditions and image quality requirements similar to those in medical computed tomography (CT).

Algorithms↗
PubMed1988

[Suicidal behavior and the broken home. Critical evaluation of a "causal hypothesis"].

It has often been hypothesized that a broken home results in a "predisposition" towards suicidal behaviour. Previous findings concerning the incidence of broken homes among suicides have revealed rates that are considerably higher than might have been expected from the base rate of the incidence of broken homes among the population as a whole. However, when considering these results, it is necessary to take into account a number of general methodological problems as well as specific problems inherent in the study of the causes of suicidal behaviour. Therefore, due to methodological objections, it can be assumed that the covariation between the variable, broken home, and suicidal behaviour, as compared with other psychiatric disturbances, has been overestimated. It seems more likely that a broken home, in combination with the simultaneous and subsequent emergence of adverse circumstances, increases the probability of the appearance of deviant behaviour in general. Therefore, it would appear that the most useful approach for understanding suicidal behaviour is to analyse the learning history and background of patients who have exhibited such behaviour, while the variable, broken home, should be regarded as being only one of several factors conditioning the failure to develop or apply adequate coping strategies.

Adolescent↗
PubMed1980

Comparative study of factor structure of Raven's Coloured Progressive Matrices.

The Raven Coloured Progressive Matrices were administered on group or individual bases to children ranging in age from 4 yr. 9 mo. to 11 yr. 0 mo. (N = 728). Factor analysis yielded three factors: 1. Perceptual closure involving complex figures and patterns with heterogeneous inner structures, 2. Concrete and abstract reasoning, 3. Completion of homogeneous patterns and recognition of given elements. Factor matrix comparisons across age groups resulted in a mean similarity coefficient of .75. Comparisons of data with earlier analyses also resulted in high similarity. This supports the hypothesis of a three-factor structure rather than a four-factor solution or a simple dual classification into items which can be solved by perceptual processes and those which require conceptual solutions.

Child↗
PubMedDate not supplied

Application of biomarkers in the clinical development of new drugs for chondroprotection in destructive joint diseases: a review.

Emerging evidence supports the concept that biochemical markers are clinically useful non-invasive diagnostic tools for the monitoring of changes in cartilage turnover in patients with destructive joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). Epidemiological studies demonstrated that measurements of different degradation products of proteins in the extracellular matrix of hyaline cartilage in urine or serum samples are (1) increased in OA or RA patients compared with healthy individuals, (2) correlate with disease activity, and (3) are predictive for the rate of changes in radiographic measures of cartilage loss. The present review provides an updated list of available biomarkers and summarize the research data arguing for their clinical utility. In addition, it addresses the question whether or not the monitoring of biomarkers during different treatment modalities could be a useful approach to characterize the chondro-protective effects of approved and candidate drugs. Finally, it briefly reviews the in vitro/ex vivo experimental settings - isolated chondrocyte cultures and articular cartilage explants - that can assist in the verification of novel markers, but also studies assessing direct effects of drug candidates on chondrocytes. Collectively, biomarkers may acquire a function as established efficacy parameters in the clinical development of novel chondro-protective agents.

Arthritis, Rheumatoid↗